Protein Alignment vtd and RAD21L1

DIOPT Version :10

• Sequence 1: NP_001015132.1
• Gene: vtd / 3354896
• FlyBaseID: FBgn0260987
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: XP_006723665.1
• Gene: RAD21L1 / 642636
• HGNCID: 16271
• Length: 564
• Species: Homo sapiens
• Alignment Length: 723
• Identity: 249/723 - (34%)
• Similarity: 349/723 - (48%)
• Gaps: 171/723 - (23%)

  Fly     1 MFYEHIILAKKGPLARIWLAAHWDKKITKAHVFETNIEKSVEGILQPKVKLALRTSGHLLLGVVR 65
            |||.|::::|:||||:|||||||:||:|||||||.|:|.::|.||.||||:||||||||||||||
Human     1 MFYTHVLMSKRGPLAKIWLAAHWEKKLTKAHVFECNLEITIEKILSPKVKIALRTSGHLLLGVVR 65

  Fly    66 IYSRKAKYLLADCNEAFVKIKMAFRPGMVDLPEGHREANVNAITLPEVFHDFDTALPELNDIDIE 130
            ||:||||||||||:|||:|:||.|.||:||||:.:.||:.|||||||.||||||  ..:|.||:.
Human    66 IYNRKAKYLLADCSEAFLKMKMTFCPGLVDLPKENFEASYNAITLPEEFHDFDT--QNMNAIDVS 128

  Fly   131 AQFSINQSRADEITMREDYGSLSLSLQDDGFGDIGFEAETPEIIRCSIPSNINDKIFDNDVLENI 195
            ..|:.||||.:|||:||::.: .|..|.:.||      |..||:|       ....||:::|.|
Human   129 EHFTQNQSRPEEITLRENFDN-DLIFQAESFG------EESEILR-------RHSFFDDNILLN- 178

  Fly   196 ESLDPHSLDAHADMPGSRL----DGDGFGDSFGQPALFEDDLFGDPSQPVEQITKESTTVLNADD 256
             |..|....:...:.|.|.    .||||||.            |...:.::.:.::...:|
Human   179 -SSGPLIEHSSGSLTGERSLFYDSGDGFGDE------------GAAGEMIDNLLQDDQNIL---- 226

  Fly   257 SDEDAIDNIH-----NVPS-PATSLVNSIEDEKEENNLNGHASVSENVPMNEITLVQNEDEGFAL 315
                 ::::|     ::|| |..||  ::|.:..|     ...|.||..|||..|:..|:|||.|
Human   227 -----LEDMHLNREISLPSEPPNSL--AVEPDNSE-----CICVPENEKMNETILLSTEEEGFTL 279

  Fly   316 APLDVSMYKGVTKAKRKRKLIIDEIKNISGEEMKAQLADTSDILTTLDLAPPTKRLMYWKETGGV 380
            .|:|:|......|.| ||:|:||.||.:|.:.:..||...:|.|..|:|||||:|||.||:.|||
Human   280 DPIDISDIAEKRKGK-KRRLLIDPIKELSSKVIHKQLTSFADTLMVLELAPPTQRLMMWKKRGGV 343

  Fly   381 EKLFSLPSRSIPARALFGNYNRQLFSHSTFFEDFSSVVPMEILALEFYTKENENALIIFNKKGRK 445
            ..|.|..::.:....|                   .:|.:..| |..:||       .|...|.|
Human   344 HTLLSTAAQDLIHAEL-------------------KMVTVPTL-LHLFTK-------CFLSSGFK 381

  Fly   446 RKNDNMSNLFLDHVPDSVVQSLEAPEVLRANHKSLGVSTVSVEIVSKEQESISCQNELTFFDNMR 510
                                              ||...:..|.|   :|.:..|| :.....|:
Human   382 ----------------------------------LGRKMIQKESV---REEVGNQN-IVETSMMQ 408

  Fly   511 SPDLLSLNEMEQFSSINELPLTPRNMNHEMGDDFNQGDSTPAGLDHGHATPQHGNIGEMDHDSVI 575
            .|     |..::.|.       |:.....:|           |..|......:.||.. :.|.|
Human   409 EP-----NYQQELSK-------PQTWKDVIG-----------GSQHSSHEDTNKNINS-EQDIV- 448

  Fly   576 PTKKTAVILNESVGTSVLSDNGVSKRTNNILKGWDNYEIPSFVGQNHGDEQMENETDEQFEERVL 640
              :..::...||   |:::|....:..      :...|:          |.:.||  |..|....
Human   449 --EMVSLAAEES---SLMNDLFAQEIE------YSPVEL----------ESLSNE--ENIETERW 490

  Fly   641 NKRAAHLFIDVR-AHFIAKDSLELSQLTSGNSRKQAAQKFYSLLVLKKFKVLHIDQSAPYADITI 704
            |.|...:...:| ::.:...|..|.:|...:.|||||.||||.|||||...:.:.||||||||..
Human   491 NGRILQMLNRLRESNKMGMQSFSLMKLCRNSDRKQAAAKFYSFLVLKKQLAIELSQSAPYADIIA 555

  Fly   705 TRGPTFEN 712
            |.||.|.|
Human   556 TMGPMFYN 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vtd	NP_001015132.1	Rad21_Rec8_N	1..103	CDD:461446	73/101 (72%)
		Rad21_Rec8_M_NXP1-like	327..404	CDD:439294	31/76 (41%)
		Rad21_Rec8	657..710	CDD:335912	28/52 (54%)
RAD21L1	XP_006723665.1	Rad21_Rec8_N	1..100	CDD:461446	73/98 (74%)
		Rad21_Rec8_M_NXP1-like	290..378	CDD:439294	37/115 (32%)
		Rad21_Rec8	510..561	CDD:335912	28/50 (56%)