DRSC/TRiP Functional Genomics Resources

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Protein Alignment vtd and RAD21

DIOPT Version :10

Sequence 1:NP_001015132.1 Gene:vtd / 3354896 FlyBaseID:FBgn0260987 Length:715 Species:Drosophila melanogaster
Sequence 2:NP_006256.1 Gene:RAD21 / 5885 HGNCID:9811 Length:631 Species:Homo sapiens


Alignment Length:759 Identity:294/759 - (38%)
Similarity:390/759 - (51%) Gaps:180/759 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MFYEHIILAKKGPLARIWLAAHWDKKITKAHVFETNIEKSVEGILQPKVKLALRTSGHLLLGVVR 65
            |||.|.:|:|:||||:||||||||||:|||||||.|:|.|||.|:.||||:||||||||||||||
Human     1 MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVR 65

  Fly    66 IYSRKAKYLLADCNEAFVKIKMAFRPGMVDLPEGHREANVNAITLPEVFHDFDTALPELNDIDIE 130
            ||.||||||||||||||:|||||||||:|||||.:|||..|||||||.|||||..||:|:|||:.
Human    66 IYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVA 130

  Fly   131 AQFSINQSRADEITMREDYGSLSLSLQDDGFGDIGFEAETPEIIR-------------------- 175
            .|||:||||.:||||||:.|::|: ||::.|||.|.:..  ||:|                    
Human   131 QQFSLNQSRVEEITMREEVGNISI-LQENDFGDFGMDDR--EIMREGSAFEDDDMLVSTTTSNLL 192

  Fly   176 ---CSIPSNINDKIFDNDVLENIESLDPHSLDAHA---------DMPGSRLDGDGFGDSFGQPAL 228
               ....||:|:||      .::|..|.:..|...         |...|..||..|.|   .|||
Human   193 LESEQSTSNLNEKI------NHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDD---PPAL 248

  Fly   229 FEDDLFGDPSQPVEQITKESTTVLNADDSDEDAIDNIHNVPSPATSLVNSIEDEKEENNLNGHAS 293
            .|..:. .|.||..            ||.|||  ||:......:...|:.:|             
Human   249 SEAGVM-LPEQPAH------------DDMDED--DNVSMGGPDSPDSVDPVE------------- 285

  Fly   294 VSENVPM----NEITLVQNEDEGFALAPLDVSMYKGVTKAKRKRKLIIDEIKNISGEEMKAQLAD 354
                 ||    ::.|||.||:|.|||.|:|:::.:  ||||||||||:|.:|.:..:.::|||:|
Human   286 -----PMPTMTDQTTLVPNEEEAFALEPIDITVKE--TKAKRKRKLIVDSVKELDSKTIRAQLSD 343

  Fly   355 TSDILTTLDLAPPTKRLMYWKETGGVEKLFSLPSRSIPARALFGNYNRQLFSHSTFFEDFSSVVP 419
            .|||:||||||||||:||.|||||||||||||     ||:.|:.|...:||:..     .:.:||
Human   344 YSDIVTTLDLAPPTKKLMMWKETGGVEKLFSL-----PAQPLWNNRLLKLFTRC-----LTPLVP 398

  Fly   420 MEILALEFYTKENENALIIFNKKGRKRKNDNMSNLFLDHVPDSVVQSLEAPEVLRAN----HKSL 480
            .::                    .::||.....||      |..::..|.|||.|.:    |:..
Human   399 EDL--------------------RKRRKGGEADNL------DEFLKEFENPEVPREDQQQQHQQR 437

  Fly   481 GV-STVSVEIVSKEQESISCQNELTFFDNMRSPDLLSLNEMEQFSSINELPLTPRNMNHEMGDDF 544
            .| ....:|..|:.|||: .:...|..|....|                 |..|:.:..:.|   
Human   438 DVIDEPIIEEPSRLQESV-MEASRTNIDESAMP-----------------PPPPQGVKRKAG--- 481

  Fly   545 NQGDSTPAGLDHGHATPQHGNIGEMDHDSV-IPTKKTAVILNESVGTSVLSDNGVSKRTNNILKG 608
             |.|..|.      ..||  .:.:|:...| :|.::...|........:|.:....|..      
Human   482 -QIDPEPV------MPPQ--QVEQMEIPPVELPPEEPPNICQLIPELELLPEKEKEKEK------ 531

  Fly   609 WDNYEIPSFVGQNHGDEQMENET----DEQFEERVLNKRAAHLFIDVRAHFIAK---DSLELSQL 666
                       :...||:.|:|.    |:..|||..|||...:...:: ..:||   :|:.|.:|
Human   532 -----------EKEDDEEEEDEDASGGDQDQEERRWNKRTQQMLHGLQ-RALAKTGAESISLLEL 584

  Fly   667 TSGNSRKQAAQKFYSLLVLKKFKVLHIDQSAPYADITITRGPTF 710
            ....:|||||.||||.|||||.:.:.:.|..||:||..|.||.|
Human   585 CRNTNRKQAAAKFYSFLVLKKQQAIELTQEEPYSDIIATPGPRF 628

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
vtdNP_001015132.1 Rad21_Rec8_N 1..103 CDD:461446 82/101 (81%)
Rad21_Rec8_M_NXP1-like 327..404 CDD:439294 48/76 (63%)
Rad21_Rec8 657..710 CDD:335912 27/55 (49%)
RAD21NP_006256.1 Rad21_Rec8_N 1..104 CDD:461446 83/102 (81%)
Required for interaction with SMARCA5. /evidence=ECO:0000269|PubMed:12198550 126..282 55/182 (30%)
Interaction with NIPBL. /evidence=ECO:0000269|PubMed:32409525 154..171 7/19 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 258..285 10/40 (25%)
Interaction with WAPL and PDS5B. /evidence=ECO:0000269|PubMed:19696148 287..403 64/147 (44%)
Rad21_Rec8_M_NXP1-like 316..395 CDD:439294 50/88 (57%)
Interaction with STAG1. /evidence=ECO:0000269|PubMed:19696148 362..403 21/70 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 423..489 20/93 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 517..558 10/57 (18%)
Rad21_Rec8 574..628 CDD:335912 25/53 (47%)

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