DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vtd and rad21l1

DIOPT Version :9

Sequence 1:	NP_001015132.1	Gene:	vtd / 3354896	FlyBaseID:	FBgn0260987	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001073519.1	Gene:	rad21l1 / 571082	ZFINID:	ZDB-GENE-061103-505	Length:	546	Species:	Danio rerio

Alignment Length:	726	Identity:	223/726 - (30%)
Similarity:	338/726 - (46%)	Gaps:	195/726 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFYEHIILAKKGPLARIWLAAHWDKKITKAHVFETNIEKSVEGILQPKVKLALRTSGHLLLGVVR 65
            |||..:..:|:|.||:|||||||:||||||||||.::|.:::.||.|::|:.|||||||||||||
Zfish     1 MFYAQLFTSKRGTLAKIWLAAHWEKKITKAHVFECDLETTIKEILSPQIKIGLRTSGHLLLGVVR 65

  Fly    66 IYSRKAKYLLADCNEAFVKIKMAFRPGMVDLPEGHREANVNAITLPEVFHDFDTALPELNDIDIE 130
            |||||.:||||||::|.||||:|||||..|||:...||.:..|||||.|.|||:.||:||.||:.
Zfish    66 IYSRKTRYLLADCSDALVKIKVAFRPGQTDLPDDAMEATLKTITLPEDFTDFDSQLPDLNTIDVV 130

  Fly   131 AQFSINQSRADEITMREDYGSLSLSLQDDGFGDIGFEAETPEIIRCSIPSNINDKIFDNDVLENI 195
            ..||:||.|.::||::|::|:|.|||:..|                             :.:::.
Zfish   131 DHFSLNQCRTEDITLKENFGNLFLSLERIG-----------------------------EEMQSY 166

  Fly   196 ESLDPHSLDAHADMPGSRLDGDGFGDSFGQPALFEDDLFGDPSQPVEQI-----TKESTTVLNAD 255
            :.|...|...|.                        |.|||....|:.|     |.|.|.:   .
Zfish   167 QGLFDQSFSVHG------------------------DCFGDEEMAVDLIDIIANTAEDTLM---S 204

  Fly   256 DSDEDAIDNIHNVPSPATSLVNSIEDEKEENNLNGHASVSENVPMNEITLVQNEDEGFALAPLDV 320
            |.:.::|:.:...|.|  :.||::|.||.|.:.....|..:   :.|.|.:.||||||||||:..
Zfish   205 DFNGNSINELPATPPP--TAVNAVEPEKPETSCLKERSSPD---VTETTFLVNEDEGFALAPVSA 264

  Fly   321 SMYKGVTKAKRKRKLIIDEIKNISGEEMKAQLADTSDILTTLDLAPPTKRLMYWKETGGVEKLFS 385
            :......:..|||||:||..|.::...::.||||.||||:.|::||||::||.|:|:|||::|.|
Zfish   265 TPCSAKKRKVRKRKLVIDRSKQLTNSAIRDQLADCSDILSPLEIAPPTRQLMEWRESGGVKQLIS 329

  Fly   386 LPSRSIPARALFGNYNRQLFSHSTFFEDFSSVVPMEILALEFYTKENENALIIFNKKGRKRKNDN 450
              |..:|                ....|...:.|.|:       ......|    |.|.:::.|
Zfish   330 --SFCLP----------------VLHPDLKQLFPSEV-------SPRRQGL----KGGARQQTD- 364

  Fly   451 MSNLFLDHVPDSVVQSLEAPEVLRANHKSLGVSTVSVEIVSKE----QESISCQN----ELTFFD 507
                               ||.:|...:. .|...:|:.|..:    |:|::.:.    :.|..|
Zfish   365 -------------------PEEMREQTRE-AVEEDTVQPVMDDWSLLQDSVAQEQPVDADTTLED 409

  Fly   508 NMRSPDLLSLNEMEQFSSINELPLTPRNMNHEMGDDFNQGDSTPAGLDHGHATPQHGNIGEMDHD 572
            ::..|:                  .|.:.|          .:..:.|:..:..|| ..|..:.|.
Zfish   410 SVCHPE------------------PPPSWN----------STIESRLEVSYPEPQ-SEISTLSHP 445

  Fly   573 SVIPTKKTAVILNESVGTSVLSDNGVSKRTNNILKGWDNYEIPSFVGQNHGDEQMENETDEQFEE 637
            || ..::|.::                .:|.::|...|                        .|:
Zfish   446 SV-EMRETPLV----------------TKTQSVLGSQD------------------------LED 469

  Fly   638 RVLNKRAAHLFIDVRAHFIAKDSL-ELSQLTSGNSRKQAAQKFYSLLVLKKFKVLHIDQSAPYAD 701
            |.:..||..|...:::...:.|:: .|..|....||...|..|:.:|||:|.:.|::.|||||:|
Zfish   470 RRMTSRAHDLLQALKSQDSSPDAVYSLHALCESGSRSYVAALFFCMLVLRKQQFLNLHQSAPYSD 534

  Fly   702 ITITRGPTFEN 712
            |..|.||.|.:
Zfish   535 IIATPGPLFHS 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vtd	NP_001015132.1	Rad21_Rec8_N	1..106	CDD:282655	68/104 (65%)
vtd	NP_001015132.1	Rad21_Rec8	657..710	CDD:282654	22/53 (42%)
rad21l1	NP_001073519.1	Rad21_Rec8_N	1..100	CDD:309801	66/98 (67%)
rad21l1	NP_001073519.1	Rad21_Rec8	495..543	CDD:282654	21/47 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593646
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1213
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1253899at2759
OrthoFinder	1	1.000	-	-		FOG0001363
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12585
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1058
SonicParanoid	1	1.000	-	-		X1093
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.840