Protein Alignment vtd and Rec8

DIOPT Version :10

• Sequence 1: NP_001015132.1
• Gene: vtd / 3354896
• FlyBaseID: FBgn0260987
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: NP_064386.2
• Gene: Rec8 / 56739
• MGIID: 1929645
• Length: 591
• Species: Mus musculus
• Alignment Length: 774
• Identity: 161/774 - (20%)
• Similarity: 259/774 - (33%)
• Gaps: 251/774 - (32%)

  Fly     2 FYEHIILAKKGPLARIWLAAHWDKKITKAHVFETNIEKSVEGILQ-------------PKVKLAL 53
            :|.:::....|..|.|||||....::.|......|:.|:.|.||.             |:.:.:|
Mouse     3 YYPNVLQRHTGCFATIWLAATRGSRLVKREYLNVNVVKTCEEILNYVLVRVQPPVAGLPRPRFSL 67

  Fly    54 RTSGHLLLGVVRIYSRKAKYLLADCNEAFVKIKMAFRPGMVDLPEGHREANVNAITLPEVFHDFD 118
            ..|..|.:||:|:|.::.:||:.|.......:..|.....:|:    .||::.::.||......:
Mouse    68 YLSAQLQIGVIRVYFQQCQYLVEDIQHILEHLHRAQLRIRIDM----EEADLPSLLLPNCLAMME 128

  Fly   119 TALPELNDIDIEAQFSINQSRADEITMRED-----YGSLSLSLQDDGFGDIG-----FEAETPEI 173
            |.                          ||     :|.:|:..:.....||.     .||.|||.
Mouse   129 TL--------------------------EDAPEPFFGKMSVDPRLPSPFDIPQIRHLLEAATPEK 167

  Fly   174 IRC-SIPSNINDKIFDNDVLENIESLDPHSLDAHADMPGSRLDGDGFGD----SFGQPALF---E 230
            .|. ::|....|....:..|..::|  |..:......|...|..:|..|    |.|...|.   :
Mouse   168 TRKETLPEATPDPRKPDRTLATVQS--PEVITLQEAEPIRMLQIEGEQDLPEISRGDLELLIAEK 230

  Fly   231 DDLFGDPSQPVEQITKESTTVLNADDSDED--AIDN---IHNVPSPATSLVNSIED-------EK 283
            ||......:...::.::....|..|:|.|:  |::.   :..:..||.:.|..|::       ..
Mouse   231 DDAILLEERQRGRLLRQRRASLPLDESREEPRALEGAGLVSALSPPAPAQVEGIQEALPGQVFPP 295

  Fly   284 EENNLNG---HASVSENVPMNEITLVQNEDEGFALAPLDV-----SMYKGVTKAKRKRKLII-DE 339
            |...:.|   .|.::|..|..|:.|.         ||...     |:.:.:.:..|:|:|:. |:
Mouse   296 EVQKMTGWEPGALLTEVTPPQELRLP---------APPSTEKRLPSLQRPLPRRHRRRQLLFWDK 351

  Fly   340 IKNISGEEMKAQLADTSDILTTLDLAPPTKRLMYWKETGGVEKLFSLPSRS--IPARALFGNYNR 402
            ...||.|:.:.|| .|........:|.|.||::    |...| ||..|:.|  :|...|
Mouse   352 ETQISREKFEEQL-QTGAHCWEYPVAQPPKRML----TSPAE-LFRTPTLSGWLPPELL------ 404

  Fly   403 QLFSHSTFFEDFSSVVPMEIL----ALEF-YTKENENALIIFNKKGRKRKNDNMSNLFLDHVPDS 462
            .|::|       .:.||..:|    .||. .|.|.|.|.    .:..:||.:.:|.:
Mouse   405 GLWTH-------CAQVPQRMLRQRPQLETEETVEEERAA----DEEERRKTEALSEI-------- 450

  Fly   463 VVQSLEAPEVLRANHKSLGVSTVSVEIVSKEQESISCQNELTFFDNMRSPDLLSLNEMEQ----- 522
                    ||||...:..|...:|.|:..:..|....:..|.      .|:..:.:|..|
Mouse   451 --------EVLREAQEPSGPLMLSSELSLEAAEDEKSRTSLI------PPEWWAWSEEGQPEPPA 501

  Fly   523 FSSINELPLTPRNMNHEMGDDFNQGDSTPAGLDHGHATPQHGNIGEMDHDSVIPTKKTAVILNES 587
            ...:.|||..|..|                                       |.:
Mouse   502 LPMLPELPEVPMEM---------------------------------------PPR--------- 518

  Fly   588 VGTSVLSDNGVSKRTNNILKGWDNYEIPSFVGQNHGDEQMENETDEQFEERVLNKRAAHLFIDVR 652
                                                        .|...|.||  ||..|.:.
Mouse   519 --------------------------------------------PELSSEAVL--RAVALKLQ-- 535

  Fly   653 AHFIAKDSLELSQLTSGNS-RKQAAQKFYSLLVLKKFKVLHIDQSAPYADITITRGPTF 710
                |...|:.|.|....| ||.|::.||.||||...|:|.::|..||..:.|..||.|
Mouse   536 ----ANKELDFSSLVPPLSPRKLASRVFYLLLVLSTQKILLVEQQKPYGPLLIRPGPKF 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vtd	NP_001015132.1	Rad21_Rec8_N	1..103	CDD:461446	27/113 (24%)
		Rad21_Rec8_M_NXP1-like	327..404	CDD:439294	22/79 (28%)
		Rad21_Rec8	657..710	CDD:335912	22/53 (42%)
Rec8	NP_064386.2	Rad21_Rec8_N	1..112	CDD:461446	27/112 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..186		6/22 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	316..336		5/28 (18%)
		Rad21_Rec8_M_Rec8	350..414	CDD:439296	21/82 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	420..447		8/30 (27%)
		Rad21_Rec8	536..590	CDD:335912	22/53 (42%)