DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vtd and rad21a

DIOPT Version :9

Sequence 1:	NP_001015132.1	Gene:	vtd / 3354896	FlyBaseID:	FBgn0260987	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_955889.1	Gene:	rad21a / 322275	ZFINID:	ZDB-GENE-030131-994	Length:	643	Species:	Danio rerio

Alignment Length:	748	Identity:	283/748 - (37%)
Similarity:	401/748 - (53%)	Gaps:	146/748 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFYEHIILAKKGPLARIWLAAHWDKKITKAHVFETNIEKSVEGILQPKVKLALRTSGHLLLGVVR 65
            |||.|.:|:|:||||:||||||||||:|||||||.|:|.|||.|:.||||:||||||||||||||
Zfish     1 MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVR 65

  Fly    66 IYSRKAKYLLADCNEAFVKIKMAFRPGMVDLPEGHREANVNAITLPEVFHDFDTALPELNDIDIE 130
            ||.||||||||||||||:|||||||||:|||||.:|||..|||||||.|||||..||:|:|||:.
Zfish    66 IYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEDNREAAYNAITLPEEFHDFDQPLPDLDDIDVA 130

  Fly   131 AQFSINQSRADEITMREDYGSLSLSLQDDGFGDIGFEAETPEIIRCSIPSNINDKIFDNDVLENI 195
            .||::||||.:||||||:.|::|| :.|:.|||.|.:..  |::|       .:..|.:.:.|:.
Zfish   131 QQFTLNQSRVEEITMREEVGNISL-MTDNDFGDFGMDDR--EMMR-------EENAFGDIIHESS 185

  Fly   196 ES---LDPHSLDAHADMPGSRLDGDGFGDS---------FGQPALFEDD---LFGDPSQPVEQIT 245
            .:   |:.....||.......||.|.|||:         .....|..:|   :|.||....:.:
Zfish   186 AANLLLEAEPGPAHLPDKTPNLDYDDFGDNNLENSDGGILMDKILSNEDGGGIFDDPPAITDSV- 249

  Fly   246 KESTTVLNADDSDEDAIDNIHNVPSPATSLVNSIEDEKEENNLNGHASVSENVPMNE-ITLVQNE 309
                 ::..|..|:|  |:..|. |||..     .|..:...:....:.::.....| .|||.||
Zfish   250 -----MMPQDHGDDD--DDFDNF-SPAGG-----PDSPDSGPVEPLPNTTDQTDQTEQTTLVPNE 301

  Fly   310 DEGFALAPLDVSMYKGVTKAKRKRKLIIDEIKNISGEEMKAQLADTSDILTTLDLAPPTKRLMYW 374
            ||.|||.|:|:::.:  ||||||||||:|.:|.:..:.::|||:|.|||:||||||||||:||.|
Zfish   302 DEAFALEPIDITVKE--TKAKRKRKLIVDSLKELDSKTIRAQLSDYSDIVTTLDLAPPTKKLMMW 364

  Fly   375 KETGGVEKLFSLPSRSIPARALFGNYNRQLFSHSTFFEDFSSVVPMEILALEFYTKENENALIIF 439
            |||||||||||||::.:        :|.:|.  ..|....:.:||.|:
Zfish   365 KETGGVEKLFSLPAQPL--------WNGRLL--KMFTRCLTPLVPDEL----------------- 402

  Fly   440 NKKGRKRKNDNMSNLFLDHVPDSVVQSLEAPEVLRANHKSLGVSTVSVEIVSKEQESISCQNELT 504
               .::||.....:|      :..::.||.|||.|                   :|.:..::::.
Zfish   403 ---RKRRKGGEADSL------EDFLKELENPEVPR-------------------EEVLGHRSDVI 439

  Fly   505 FFDNMRSPDLLSLNEME-QFSSINELPLTPRNMNHEMGDDFNQGDSTPAGLDHGHATPQHGNIGE 568
            ....|..|.:|..:.|| ..::::|..:.|              .|...||       :..::..
Zfish   440 DQTIMEEPSMLQASSMEGSRTALDESMMPP--------------PSRQRGL-------KRKSLET 483

  Fly   569 MDHDSVIP----TKKTAVILNESVGTSVLSDNGVS---KRTNNILKGWDNYEIPSF--------- 617
            ::.|:|:|    .::|...|::||.:..|....|.   :.|.|:.:     .||..
Zfish   484 LEKDAVLPPMGVLEQTLQPLDQSVLSHQLEMPQVELPPEDTTNLSR-----LIPELDLLDEKSKD 543

  Fly   618 VGQNHGDEQMENET--DEQFEERVLNKRAAHLFIDVRAHFIAK---DSLELSQLTSGNSRKQAAQ 677
            ..::..||:.|...  |:..|||..|||...:...:: ..:||   .|:.|.:|...|::||||.
Zfish   544 KDKDDSDEEGEEGQGGDQDQEERRWNKRTQQMLHGLQ-RVVAKTGAQSIGLLELCRNNNKKQAAA 607

  Fly   678 KFYSLLVLKKFKVLHIDQSAPYADITITRGPTF 710
            ||||.|||||.:.:.:.|:.||:||....||.|
Zfish   608 KFYSFLVLKKQQAIDLTQTEPYSDIIAAPGPRF 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vtd	NP_001015132.1	Rad21_Rec8_N	1..106	CDD:282655	84/104 (81%)
vtd	NP_001015132.1	Rad21_Rec8	657..710	CDD:282654	26/55 (47%)
rad21a	NP_955889.1	Rad21_Rec8_N	1..104	CDD:282655	83/102 (81%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	234..298		15/77 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..479		9/52 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..566		6/33 (18%)
		Rad21_Rec8	586..640	CDD:282654	24/53 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593644
Domainoid	1	1.000	190	1.000	Domainoid score	I3204
eggNOG	1	0.900	-	-		E1_KOG1213
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38161
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1886
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1253899at2759
OrthoFinder	1	1.000	-	-		FOG0001363
OrthoInspector	1	1.000	-	-		otm25500
orthoMCL	1	0.900	-	-		OOG6_103388
Panther	1	1.100	-	-	O	PTHR12585
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1058
SonicParanoid	1	1.000	-	-		X1093
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790