DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vtd and rad21

DIOPT Version :9

Sequence 1:	NP_001015132.1	Gene:	vtd / 3354896	FlyBaseID:	FBgn0260987	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_588151.1	Gene:	rad21 / 2539447	PomBaseID:	SPCC338.17c	Length:	628	Species:	Schizosaccharomyces pombe

Alignment Length:	794	Identity:	197/794 - (24%)
Similarity:	307/794 - (38%)	Gaps:	259/794 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFYEHIILAKKGPLARIWLAAHWDKKITKAHVFETNIEKSVEGIL-QPKVKLALRTSGHLLLGVV 64
            |||...||:||||||::||||||:||::|.....|:||:||..|: :....:|||.||.|:||||
pombe     1 MFYSEAILSKKGPLAKVWLAAHWEKKLSKVQTLHTSIEQSVHAIVTEETAPMALRLSGQLMLGVV 65

  Fly    65 RIYSRKAKYLLADCNEAFVKIKMAFRPGMVDLPE---------GHREANVNA-ITLPEVFHDFDT 119
            |||||||:|||.||.||.:::||:|:||.||:.|         |......:| :||||...:||.
pombe    66 RIYSRKARYLLEDCTEALMRLKMSFQPGQVDMIEPATALQSLKGKDAVTQSANLTLPETITEFDL 130

  Fly   120 ALPELNDIDIE-AQFSINQSRADE--------ITMREDYGSLSLSLQ-------DDGF------- 161
            .:|: :..|.: :|.....||:..        |:....:.|..||::       :.||
pombe   131 LVPD-STFDFQWSQLLRTPSRSSNTLELHSLPISSSPSFPSSQLSIEAGRNAQVESGFSLGESFA 194

  Fly   162 ---GDIGFE-------AETPEIIRCSIPSNINDKIFD----------NDVLENIESLDPHSLDAH 206
               .|:.|.       |.||..:.....|.|:.::..          :.::....:..|.|...|
pombe   195 HVGNDMQFHLPISNSGAATPRSVHSDNQSQISIEVGRDAPAAAATDLSGIIGPQMTKSPASSVTH 259

  Fly   207 ADMPGS-RLDGDGFGDSFGQPA------LFEDDLFGDPSQPVEQITKESTTVLNADDSDEDAIDN 264
            ...|.. .:.|....|....|.      |..|||.||          |......|.::||.|..:
pombe   260 FSTPSMLPIGGTSLDDELLAPVDDLNLDLGLDDLLGD----------EQGANAPAIEADEQAETS 314

  Fly   265 IHNVPSPATSLVNSIEDEKEENNLNGHASVSENVPMNEITLVQNEDEGFALAPLDVSMYKGVTKA 329
            ..::||      :.:||   :::....|.|.|...:...|..|.|    .:.|         .|.
pombe   315 SIHLPS------DIMED---DSSRPAAAGVEEGQVVESATAPQQE----KINP---------QKT 357

  Fly   330 KRKRKLIIDEIKNISGEEMKAQLADTSDILTTLDLAPPTKRLMYWKETGGVEKLFSLPSRSIPAR 394
            .|:::.|||.:..:|.::||.||||||.|.:.|                      .|.:.||...
pombe   358 VRRQRAIIDPVTELSSKQMKKQLADTSSITSPL----------------------CLNTSSIVFN 400

  Fly   395 ALF-----GNYNRQLFSHSTFFEDFSSVVPM--EILALEFYTKENENALIIFNKKGRKRKNDNMS 452
            |..     |.:|..:||        |::.|.  |:|..:|     :.|::      |||||::
pombe   401 ATVNFTRNGKFNTSIFS--------SNLNPKVNELLQADF-----KQAIL------RKRKNES-- 444

  Fly   453 NLFLDHVPDSVVQSLEAPEVLRANHKSLGVSTVSVEIVSKEQESISCQNELTFFDNMRSPDLLSL 517
                   |:         ||..|.|:....||       :.||:.    |:...:.:.:.:|.::
pombe   445 -------PE---------EVEPAKHQRTDTST-------ENQETA----EVLDPEEIAAAELANI 482

  Fly   518 NEMEQFSSINELPLTPRNMNHEMGD------------DFNQGDSTPAGLDHGHATPQHGNIGEMD 570
            .|....:...|..:.|.....|:|.            |.:..|:.|..||....      :|...
pombe   483 TEAAIATLPQETVVQPEGEAPELGSPMGFPVTALESADDSLFDAPPVMLDEADL------LGSER 541

  Fly   571 HDS----VIPTKKTAVILNESVGTSVLSDNGVSKRTNNILKGWDNYEIPSFVGQNHGDEQMENET 631
            .||    .:|:.:||                    .:::...||.|              .|.|
pombe   542 LDSSVSEALPSSQTA--------------------KDSLRNKWDPY--------------TEGE- 571

  Fly   632 DEQFEERVLNKRAAHLFIDVRAHFIAKDSLELSQLTSGNSRKQAAQKFYSLLVLKKFKVLHIDQS 696
                                        .:....|::|.:|::|.|.|:.:|||....|:.:.|.
pombe   572 ----------------------------KVSFQTLSAGCNREEAVQLFFDVLVLATKDVISVKQD 608

  Fly   697 -APYADITIT--RG 707
             |...:||:|  ||
pombe   609 VAIQNEITLTAKRG 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vtd	NP_001015132.1	Rad21_Rec8_N	1..106	CDD:282655	59/114 (52%)
vtd	NP_001015132.1	Rad21_Rec8	657..710	CDD:282654	17/54 (31%)
rad21	NP_588151.1	Rad21_Rec8_N	1..97	CDD:282655	56/95 (59%)
rad21	NP_588151.1	Rad21_Rec8	568..623	CDD:282654	19/84 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	124	1.000	Domainoid score	I1414
eggNOG	1	0.900	-	-		E1_KOG1213
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	143	1.000	Inparanoid score	I1348
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001363
OrthoInspector	1	1.000	-	-		oto100929
orthoMCL	1	0.900	-	-		OOG6_103388
Panther	1	1.100	-	-	LDO	PTHR12585
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1058
SonicParanoid	1	1.000	-	-		X1093
TreeFam	1	0.960	-	-
	11	10.940