Protein Alignment rl and CDKL1

DIOPT Version :10

• Sequence 1: NP_001015122.1
• Gene: rl / 3354888
• FlyBaseID: FBgn0003256
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_004187.3
• Gene: CDKL1 / 8814
• HGNCID: 1781
• Length: 357
• Species: Homo sapiens
• Alignment Length: 355
• Identity: 111/355 - (31%)
• Similarity: 175/355 - (49%)
• Gaps: 56/355 - (15%)

  Fly    37 RYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKISPFEHQTYCQR-TLREITILTRFKHENIIDIR 100
            :|.|:..||||:||:|....:..|.|.|||||....|.....:: .||||.:|.:.||.|::::.
Human     3 KYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLL 67

  Fly   101 DILRVDSIDQMRDVYIV-QCLMETDLYKLLKTQRLSNDHICYFL-YQILRGLKYIHSANVLHRDL 163
            ::.|     :.|.:::| :....|.|::|.:.||...:|:...: :|.|:.:.:.|..|.:|||:
Human    68 EVFR-----RKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDV 127

  Fly   164 KPSNLLLNKTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVG 228
            ||.|:|:.|...:|:||||.||:.....|   :.|:||||||||:||:::....|...:|:|::|
Human   128 KPENILITKHSVIKLCDFGFARLLTGPSD---YYTDYVATRWYRSPELLVGDTQYGPPVDVWAIG 189

  Fly   229 CILAEMLSNRPIFPGKHYLDQLNHILGVLGS--------------------PSRDDLECIINEKA 273
            |:.||:||..|::|||..:|||..|...||.                    |..:|:|
Human   190 CVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDME------- 247

  Fly   274 RNYLESLPFKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYLEQYYDPGDEPVA 338
                         |....|||....||.||...|..:|.:|:..|:.|.|||.|...:     :.
Human   248 -------------PLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYFENIRE-----IE 294

  Fly   339 EVPFRINMENDDISRDALKSLIFEETLKFK 368
            ::....|.......|.:.|...|.||.|.:
Human   295 DLAKEHNKPTRKTLRKSRKHHCFTETSKLQ 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	110/351 (31%)
CDKL1	NP_004187.3	STKc_CDKL1_4	2..287	CDD:270837	102/311 (33%)
		[NKR]KIAxRE	45..51		1/5 (20%)