Protein Alignment rl and CDK10

DIOPT Version :10

• Sequence 1: NP_001015122.1
• Gene: rl / 3354888
• FlyBaseID: FBgn0003256
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: XP_011521707.1
• Gene: CDK10 / 8558
• HGNCID: 1770
• Length: 392
• Species: Homo sapiens
• Alignment Length: 379
• Identity: 115/379 - (30%)
• Similarity: 176/379 - (46%)
• Gaps: 96/379 - (25%)

  Fly    18 EVPQSNAEVIRGQ-IFEVGP-----------RYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKIS 70
            |..|...:.||.: .|.|.|           .:.||..||||.||:|..|.||.|::.||:||:.
Human     7 ECEQIRLKCIRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVR 71

  Fly    71 --------PFEHQTYCQRTLREITILTRFKHENIIDIRDILRVDSIDQMRDVYIVQCLMETDLYK 127
                    |..       :|||||:|.|.:|.||:::::::..:.::   .:::|....|.||..
Human    72 MDKEKDGIPIS-------SLREITLLLRLRHPNIVELKEVVVGNHLE---SIFLVMGYCEQDLAS 126

  Fly   128 LLKTQ--RLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL-NKTCDLKICDFGLARI--- 186
            ||:..  ..|...:...:.|:||||:|:|...::|||||.||||: :|.| :|..||||||.
Human   127 LLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGC-VKTADFGLARAYGV 190

  Fly   187 -ADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIW------------------------- 225
             ..|       :|..|.|.||||||::|.:...|.|||:|
Human   191 PVKP-------MTPKVVTLWYRAPELLLGTTTQTTSIDMWVSKGLAAVRSSVPRAGGVSRRLAAV 248

  Fly   226 -------SVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSRD------DLECIINEKARNYL 277
                   :|||||||:|::||:.||...:.|::.|:.:||:||.:      .|..:    .:..|
Human   249 RSTVLCRAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLV----GQYSL 309

  Fly   278 ESLPF---KPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYLEQ 328
            ...|:   |...||      .....|.||..:..::|.||....:.|...|.::
Human   310 RKQPYNNLKHKFPW------LSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKE 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	111/364 (30%)
CDK10	XP_011521707.1	STKc_CDK10	31..371	CDD:173742	108/355 (30%)