Protein Alignment rl and CDKL5

DIOPT Version :10

• Sequence 1: NP_001015122.1
• Gene: rl / 3354888
• FlyBaseID: FBgn0003256
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_003150.1
• Gene: CDKL5 / 6792
• HGNCID: 11411
• Length: 1030
• Species: Homo sapiens
• Alignment Length: 306
• Identity: 103/306 - (33%)
• Similarity: 172/306 - (56%)
• Gaps: 36/306 - (11%)

  Fly    32 FEVGPRYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKISPF-EHQTYCQRTLREITILTRFKHEN 95
            ||:      |..:||||||:|:......|::.|||||.... |::...:.||||:.:|...|.||
Human    13 FEI------LGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQEN 71

  Fly    96 IIDIRDILRVDSIDQMRDVYIVQCLMETDLYKLLKTQRLSN----DHICYFLYQILRGLKYIHSA 156
            |:::::..|     :...:|:|...:|.::.:||  :.:.|    :.:..::||:::.:.:.|..
Human    72 IVELKEAFR-----RRGKLYLVFEYVEKNMLELL--EEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129

  Fly   157 NVLHRDLKPSNLLLNKTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKS 221
            :::|||:||.|||::....||:||||.||... |.::..: ||||||||||:||::|.:. |.||
Human   130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLS-EGNNANY-TEYVATRWYRSPELLLGAP-YGKS 191

  Fly   222 IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECIINE--------KARNYLE 278
            :|:|||||||.|:...:|:|||:..:|||..|..|||....:.::...:.        .|.|:.:
Human   192 VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQ 256

  Fly   279 SLPFKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHP 324
            ||.       .:.....:::.|||:..:|..:|..|...|:.|.||
Human   257 SLE-------RRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHP 295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	103/306 (34%)
CDKL5	NP_003150.1	STKc_CDKL5	11..297	CDD:270838	103/306 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..349
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	382..566
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	646..834