DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rl and MAPK8

DIOPT Version :9

Sequence 1:	NP_001015122.1	Gene:	rl / 3354888	FlyBaseID:	FBgn0003256	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001265476.1	Gene:	MAPK8 / 5599	HGNCID:	6881	Length:	427	Species:	Homo sapiens

Alignment Length:	376	Identity:	144/376 - (38%)
Similarity:	227/376 - (60%)	Gaps:	34/376 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NGTGSTEVPQSNAEVIRGQIFEVGPRYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKIS-PFEHQ 75
            |...|.|:..|...|::        ||..|..||.||.|:|.:|.|.:..:.|||||:| ||::|
Human     8 NNFYSVEIGDSTFTVLK--------RYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQ 64

  Fly    76 TYCQRTLREITILTRFKHENIIDIRDILRVD-SIDQMRDVYIVQCLMETDLYKLLKTQRLSNDHI 139
            |:.:|..||:.::....|:|||.:.::.... |:::.:|||||..||:.:|.::::.: |.::.:
Human    65 THAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERM 128

  Fly   140 CYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLARIADPEHDHTGF-LTEYVAT 203
            .|.|||:|.|:|::|||.::||||||||:::...|.|||.||||||.|.     |.| :|.||.|
Human   129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-----TSFMMTPYVVT 188

  Fly   204 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECI 268
            |:|||||::| ..||.:::||||||||:.||:....:|||..::||.|.::..||:|..:.:: .
Human   189 RYYRAPEVIL-GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMK-K 251

  Fly   269 INEKARNYLESLPFKPNVPWAKLFPN----AD--------ALALDLLGKMLTFNPHKRIPVEEAL 321
            :....|.|:|:.|......:.||||:    ||        :.|.|||.|||..:..|||.|:|||
Human   252 LQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEAL 316

  Fly   322 AHPYLEQYYDP--GDEPVAEVPFRINMENDDISRDALKSLIFEETLKFKER 370
            .|||:..:|||  .:.|..::|.: .::..:.:.:..|.||::|.:..:||
Human   317 QHPYINVWYDPSEAEAPPPKIPDK-QLDEREHTIEEWKELIYKEVMDLEER 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	137/350 (39%)
rl	NP_001015122.1	S_TKc	38..326	CDD:214567	126/302 (42%)
MAPK8	NP_001265476.1	STKc_JNK	25..360	CDD:270840	136/343 (40%)
		TXY	183..185		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..427
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D741207at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920