DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rl and MAPK4

DIOPT Version :9

Sequence 1:	NP_001015122.1	Gene:	rl / 3354888	FlyBaseID:	FBgn0003256	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_002738.2	Gene:	MAPK4 / 5596	HGNCID:	6878	Length:	587	Species:	Homo sapiens

Alignment Length:	337	Identity:	143/337 - (42%)
Similarity:	208/337 - (61%)	Gaps:	30/337 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 FEVGPRYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKISPFEHQTYCQRTLREITILTRFKHENI 96
            :::|.|::....:|.|..|:|:||.|:...::||:|||:..:.:: .:..||||.|:.|..|:||
Human    14 YDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARS-MKHALREIKIIRRLDHDNI 77

  Fly    97 IDIRDILRVDSIDQMRDV------YIVQCLMETDLYKLLKTQRLSNDHICYFLYQILRGLKYIHS 155
            :.:.::|.....|...::      ||||..|||||.:||:...|:.:|...|:||:|||||||||
Human    78 VKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRGLKYIHS 142

  Fly   156 ANVLHRDLKPSNLLLNKTCD--LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY 218
            ||||||||||:|:.:: |.|  |||.|||||||.|..:.|.|:|:|.:.|:|||:|.::|:...|
Human   143 ANVLHRDLKPANIFIS-TEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNY 206

  Fly   219 TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL---GVLGSPSRDDLECIINEKARNYLESL 280
            ||:||:|:.||||||||:.|.:|.|.|.|:|:..||   .|:....:|:|           |..:
Human   207 TKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDEL-----------LRVM 260

  Fly   281 P------FKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYLEQYYDPGDEPVAE 339
            |      ::...|..||.|..::.|:|.|.|:|||||..|:..|..|.|||:..|..|.|||.::
Human   261 PSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQ 325

  Fly   340 VPFRINMENDDI 351
            .||||..|.|||
Human   326 HPFRIEDEIDDI 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	143/337 (42%)
rl	NP_001015122.1	S_TKc	38..326	CDD:214567	127/304 (42%)
MAPK4	NP_002738.2	STKc_MAPK4_6	14..351	CDD:143359	143/337 (42%)
		SEG motif	186..188		0/1 (0%)
		FRIEDE motif	328..333		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..413
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	499..534
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D741207at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820