DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rl and Mapk8

DIOPT Version :9

Sequence 1:	NP_001015122.1	Gene:	rl / 3354888	FlyBaseID:	FBgn0003256	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001297382.1	Gene:	Mapk8 / 26419	MGIID:	1346861	Length:	427	Species:	Mus musculus

Alignment Length:	376	Identity:	144/376 - (38%)
Similarity:	227/376 - (60%)	Gaps:	34/376 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NGTGSTEVPQSNAEVIRGQIFEVGPRYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKIS-PFEHQ 75
            |...|.|:..|...|::        ||..|..||.||.|:|.:|.|.:..:.|||||:| ||::|
Mouse     8 NNFYSVEIGDSTFTVLK--------RYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQ 64

  Fly    76 TYCQRTLREITILTRFKHENIIDIRDILRVD-SIDQMRDVYIVQCLMETDLYKLLKTQRLSNDHI 139
            |:.:|..||:.::....|:|||.:.::.... |:::.:|||||..||:.:|.::::.: |.::.:
Mouse    65 THAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERM 128

  Fly   140 CYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLARIADPEHDHTGF-LTEYVAT 203
            .|.|||:|.|:|::|||.::||||||||:::...|.|||.||||||.|.     |.| :|.||.|
Mouse   129 SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG-----TSFMMTPYVVT 188

  Fly   204 RWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECI 268
            |:|||||::| ..||.:::||||||||:.||:....:|||..::||.|.::..||:|..:.:: .
Mouse   189 RYYRAPEVIL-GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMK-K 251

  Fly   269 INEKARNYLESLPFKPNVPWAKLFPN----AD--------ALALDLLGKMLTFNPHKRIPVEEAL 321
            :....|.|:|:.|......:.||||:    ||        :.|.|||.|||..:..|||.|:|||
Mouse   252 LQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEAL 316

  Fly   322 AHPYLEQYYDP--GDEPVAEVPFRINMENDDISRDALKSLIFEETLKFKER 370
            .|||:..:|||  .:.|..::|.: .::..:.:.:..|.||::|.:..:||
Mouse   317 QHPYINVWYDPSEAEAPPPKIPDK-QLDEREHTIEEWKELIYKEVMDLEER 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	137/350 (39%)
rl	NP_001015122.1	S_TKc	38..326	CDD:214567	126/302 (42%)
Mapk8	NP_001297382.1	STKc_JNK	25..360	CDD:270840	136/343 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D741207at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920