DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rl and Mapk14

DIOPT Version :9

Sequence 1:NP_001015122.1 Gene:rl / 3354888 FlyBaseID:FBgn0003256 Length:376 Species:Drosophila melanogaster
Sequence 2:NP_001161980.1 Gene:Mapk14 / 26416 MGIID:1346865 Length:360 Species:Mus musculus


Alignment Length:354 Identity:168/354 - (47%)
Similarity:238/354 - (67%) Gaps:9/354 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 STEVPQSNAEVIRGQIFEVGPRYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKIS-PFEHQTYCQ 79
            |.|.|....:.:...|:||..||..|:.:|.||||.|.:|.||.|..|||:||:| ||:...:.:
Mouse     2 SQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAK 66

  Fly    80 RTLREITILTRFKHENIIDIRDILR-VDSIDQMRDVYIVQCLMETDLYKLLKTQRLSNDHICYFL 143
            ||.||:.:|...||||:|.:.|:.. ..|:::..|||:|..||..||..::|.|:|::||:.:.:
Mouse    67 RTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLI 131

  Fly   144 YQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRA 208
            |||||||||||||:::|||||||||.:|:.|:|||.||||||..|.|      :|.|||||||||
Mouse   132 YQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRA 190

  Fly   209 PEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECIINEKA 273
            ||||||...|.:::||||||||:||:|:.|.:|||..:::||..|:.:.|:|....:..:.:.:|
Mouse   191 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRMPSHEA 255

  Fly   274 RNYLESLPFKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYLEQYYDPGDEPVA 338
            |||::||...|.:.:|.:|..|:.||:|||.|||..:..|||...:||||.|..||:||.|||||
Mouse   256 RNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVA 320

  Fly   339 EVPFRINMENDDISRDALKSLIFEETLKF 367
            : |:..:.|:.|:..|..|||.::|.:.|
Mouse   321 D-PYDQSFESRDLLIDEWKSLTYDEVISF 348

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rlNP_001015122.1 STKc_ERK1_2_like 32..366 CDD:270839 163/335 (49%)
S_TKc 38..326 CDD:214567 142/289 (49%)
Mapk14NP_001161980.1 STKc_p38alpha 6..350 CDD:143382 166/350 (47%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0660
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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