DRSC/TRiP Functional Genomics Resources

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Protein Alignment rl and Mapk7

DIOPT Version :10

Sequence 1:NP_001015122.1 Gene:rl / 3354888 FlyBaseID:FBgn0003256 Length:376 Species:Drosophila melanogaster
Sequence 2:NP_035971.1 Gene:Mapk7 / 23939 MGIID:1346347 Length:806 Species:Mus musculus


Alignment Length:378 Identity:179/378 - (47%)
Similarity:249/378 - (65%) Gaps:17/378 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 EEFNSSGSVVNGTGSTEVPQSNAEVIRGQ----IFEVGPRYIKLAYIGEGAYGMVVSADDTLTNQ 62
            |..:::.|||         ..|..:::.:    .|:||..|..:..||.||||:|.||...||.|
Mouse    24 EPVHTAASVV---------AKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQ 79

  Fly    63 RVAIKKI-SPFEHQTYCQRTLREITILTRFKHENIIDIRDILR-VDSIDQMRDVYIVQCLMETDL 125
            :|||||| :.|:..|..:|||||:.||..|||:|||.|:|||: .....:.|.||:|..|||:||
Mouse    80 QVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILKPTVPYGEFRSVYVVLDLMESDL 144

  Fly   126 YKLL-KTQRLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLAR-IAD 188
            :::: .:|.|:.:|:.|||||:||||||:|||.|:||||||||||:|:.|:|||.|||:|| :..
Mouse   145 HQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCT 209

  Fly   189 PEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI 253
            ...:|..|:|||||||||||||:||:...||::||:||||||..|||:.|.:||||:|:.||..|
Mouse   210 SPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLI 274

  Fly   254 LGVLGSPSRDDLECIINEKARNYLESLPFKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVE 318
            :.|||:||...::.:..|:.|.|::|||.:..|||..::|.||..||.|||:||.|.|..||...
Mouse   275 MMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAA 339

  Fly   319 EALAHPYLEQYYDPGDEPVAEVPFRINMENDDISRDALKSLIFEETLKFKERQ 371
            .||.||:|.:|:||.|||....||....:.:.::|:.:|..|..|...|..|:
Mouse   340 AALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARR 392

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rlNP_001015122.1 STKc_ERK1_2_like 32..366 CDD:270839 172/337 (51%)
Mapk7NP_035971.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Required for cytoplasmic targeting 2..77 18/61 (30%)
STKc_ERK5 49..384 CDD:270842 171/334 (51%)
Required for binding to MAP2K5 78..139 30/60 (50%)
Necessary for oligomerization 140..406 128/253 (51%)
TXY 219..221 1/1 (100%)
May not be required for kinase activity, required to stimulate MEF2C activity 407..806
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 424..473
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..727
Nuclear localization signal 505..539
Blue background indicates that the domain is not in the aligned region.

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