DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rl and Mapk7

DIOPT Version :9

Sequence 1:	NP_001015122.1	Gene:	rl / 3354888	FlyBaseID:	FBgn0003256	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001277963.1	Gene:	Mapk7 / 23939	MGIID:	1346347	Length:	806	Species:	Mus musculus

Alignment Length:	378	Identity:	179/378 - (47%)
Similarity:	249/378 - (65%)	Gaps:	17/378 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EEFNSSGSVVNGTGSTEVPQSNAEVIRGQ----IFEVGPRYIKLAYIGEGAYGMVVSADDTLTNQ 62
            |..:::.|||         ..|..:::.:    .|:||..|..:..||.||||:|.||...||.|
Mouse    24 EPVHTAASVV---------AKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQ 79

  Fly    63 RVAIKKI-SPFEHQTYCQRTLREITILTRFKHENIIDIRDILR-VDSIDQMRDVYIVQCLMETDL 125
            :|||||| :.|:..|..:|||||:.||..|||:|||.|:|||: .....:.|.||:|..|||:||
Mouse    80 QVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILKPTVPYGEFRSVYVVLDLMESDL 144

  Fly   126 YKLL-KTQRLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLAR-IAD 188
            :::: .:|.|:.:|:.|||||:||||||:|||.|:||||||||||:|:.|:|||.|||:|| :..
Mouse   145 HQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCT 209

  Fly   189 PEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI 253
            ...:|..|:|||||||||||||:||:...||::||:||||||..|||:.|.:||||:|:.||..|
Mouse   210 SPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLI 274

  Fly   254 LGVLGSPSRDDLECIINEKARNYLESLPFKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVE 318
            :.|||:||...::.:..|:.|.|::|||.:..|||..::|.||..||.|||:||.|.|..||...
Mouse   275 MMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAA 339

  Fly   319 EALAHPYLEQYYDPGDEPVAEVPFRINMENDDISRDALKSLIFEETLKFKERQ 371
            .||.||:|.:|:||.|||....||....:.:.::|:.:|..|..|...|..|:
Mouse   340 AALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARR 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	172/337 (51%)
rl	NP_001015122.1	S_TKc	38..326	CDD:214567	156/291 (54%)
Mapk7	NP_001277963.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Required for cytoplasmic targeting	2..77		18/61 (30%)
		STKc_ERK5	49..384	CDD:270842	171/334 (51%)
		Required for binding to MAP2K5	78..139		30/60 (50%)
		Necessary for oligomerization	140..406		128/253 (51%)
		TXY	219..221		1/1 (100%)
		May not be required for kinase activity, required to stimulate MEF2C activity	407..806
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..473
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..727
		Nuclear localization signal	505..539
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D309855at33208
OrthoFinder	1	1.000	-	-		FOG0000164
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100339
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X259
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720