DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rl and Mapk4

DIOPT Version :9

Sequence 1:	NP_001015122.1	Gene:	rl / 3354888	FlyBaseID:	FBgn0003256	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_766220.2	Gene:	Mapk4 / 225724	MGIID:	2444559	Length:	583	Species:	Mus musculus

Alignment Length:	334	Identity:	143/334 - (42%)
Similarity:	205/334 - (61%)	Gaps:	24/334 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 FEVGPRYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKISPFEHQTYCQRTLREITILTRFKHENI 96
            :::|.|:|....:|.|..|:|:||.|:...::||:|||...:.:: .:..||||.|:.|..|:||
Mouse    14 YDLGGRFIDFQPLGFGVNGLVLSATDSRACRKVAVKKIVLSDARS-MKHALREIKIIRRLDHDNI 77

  Fly    97 IDIRDILRVDSIDQMRDV------YIVQCLMETDLYKLLKTQRLSNDHICYFLYQILRGLKYIHS 155
            :.:.::|.....|...::      ||||..|||||..||:...|:.||...|:||:|||||||||
Mouse    78 VKVYEVLGPKGSDLQGELFKFSVAYIVQEYMETDLACLLEQGTLTEDHAKLFMYQLLRGLKYIHS 142

  Fly   156 ANVLHRDLKPSNLLLNKTCD--LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGY 218
            ||||||||||:|:.:: |.|  |||.|||||||.|..:.|.|:|:|.:.|:|||:|.::|:...|
Mouse   143 ANVLHRDLKPANIFIS-TEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNY 206

  Fly   219 TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECIINEKARNYLESLP-- 281
            ||:||:|:.||||||||:.:.:|.|.|.|:|:..||        |.:..:..|.....|..:|
Mouse   207 TKAIDMWAAGCILAEMLTGKMLFAGAHELEQMQLIL--------DTIPVVREEDKEELLRVMPSF 263

  Fly   282 ----FKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYLEQYYDPGDEPVAEVPF 342
                ::...|..||.|:.::.|:|.|.|:|||||..|:..|..|.|||:..|..|.|||.::.||
Mouse   264 VSSTWEVKRPLRKLLPDVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPF 328

  Fly   343 RINMENDDI 351
            ||..|.|||
Mouse   329 RIEDEIDDI 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	143/334 (43%)
rl	NP_001015122.1	S_TKc	38..326	CDD:214567	127/301 (42%)
Mapk4	NP_766220.2	STKc_MAPK4_6	14..351	CDD:143359	143/334 (43%)
		SEG motif	186..188		0/1 (0%)
		FRIEDE motif	328..333		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	366..410
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	495..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D741207at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820