Protein Alignment rl and MAPK15

DIOPT Version :10

• Sequence 1: NP_001015122.1
• Gene: rl / 3354888
• FlyBaseID: FBgn0003256
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: XP_011515227.1
• Gene: MAPK15 / 225689
• HGNCID: 24667
• Length: 565
• Species: Homo sapiens
• Alignment Length: 359
• Identity: 142/359 - (39%)
• Similarity: 202/359 - (56%)
• Gaps: 36/359 - (10%)

  Fly    48 AYGMVVSADDTLTNQRVAIKKI-SPFEHQT-------------------YCQRTLREITILTRF- 91
            |||:|..|.|..|.:.|||||| ..|..:|                   ..|||.||||:|..|
Human    25 AYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQDMGFLLAPPTHTPVFLSLQRTFREITLLQEFG 89

  Fly    92 KHENIIDIRDILRVDSIDQMRDVYIVQCLMETDLYKLLKTQRLSND-HICYFLYQILRGLKYIHS 155
            .|.|||.:.|::|.::   .||:|:|...|:|||..:::...|..| |:....||:||..:::||
Human    90 DHPNIISLLDVIRAEN---DRDIYLVFEFMDTDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHS 151

  Fly   156 ANVLHRDLKPSNLLLNKTCDLKICDFGLAR-IAD-PEHDHTGFLTEYVATRWYRAPEIMLNSKGY 218
            .:|:|||.||||:||:..|.:|:||||||| :.| ||......:|||||||||||||::|:|..|
Human   152 GHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLLSSHRY 216

  Fly   219 TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECIINEKARNYLESLPFK 283
            |..:|:||:||||.|||..||:|||...|.||..||..:..||.:||..:.:....:.|..|..:
Human   217 TLGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGCRASVLHQLGSR 281

  Fly   284 PNVPW-AKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYLEQYYDPGDEPVAEVPFRINM- 346
            |.... |.|.|:....|||||.::|.|.|.||:...:||.|||:::::.|.||...|...|...
Human   282 PRQTLDALLPPDTSPEALDLLRRLLVFAPDKRLSATQALQHPYVQRFHCPSDEWAREADVRPRAH 346

  Fly   347 ENDDISRDALKSLIFEETLK-------FKERQPD 373
            |...:|....:|.:::..|:       .:|:.|:
Human   347 EGVQLSVPEYRSRVYQMILECGGSSGTSREKGPE 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	139/343 (41%)
MAPK15	XP_011515227.1	STKc_MAPK15-like	25..364	CDD:270841	139/341 (41%)