Protein Alignment rl and Nlk

DIOPT Version :10

• Sequence 1: NP_001015122.1
• Gene: rl / 3354888
• FlyBaseID: FBgn0003256
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_032728.3
• Gene: Nlk / 18099
• MGIID: 1201387
• Length: 527
• Species: Mus musculus
• Alignment Length: 357
• Identity: 148/357 - (41%)
• Similarity: 214/357 - (59%)
• Gaps: 34/357 - (9%)

  Fly    44 IGEGAYGMVVSADDTLTNQRVAIKKI-SPFEHQTYCQRTLREITILTRFKHENIIDIRDILRVDS 107
            ||.||:|:|.|..|....:|||:||: :.|::...|:|..||:.:|..|||:|::...|||:...
Mouse   144 IGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPH 208

  Fly   108 IDQMRDVYIVQCLMETDLYKLL-KTQRLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN 171
            ||...::|:|..||::||:|:: ..|.||:||:..|||||||||||:|||.:||||:||.|||:|
Mouse   209 IDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVN 273

  Fly   172 KTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 236
            ..|.||||||||||:  .|.|.:..:|:.|.|::||||||::.|:.|:.:|||||||||.||:|.
Mouse   274 SNCVLKICDFGLARV--EELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLG 336

  Fly   237 NRPIFPGKHYLDQLNHILGVLGSPSRDDLE--CIINEKARNYLESLPFK-PNVP-WAKLFPNADA 297
            .|.:|..:..:.||:.|..:||:||.:.:.  |   |.|:.::...|.| |::| ...|...|..
Mouse   337 RRILFQAQSPIQQLDLITDLLGTPSLEAMRTAC---EGAKAHILRGPHKQPSLPVLYTLSSQATH 398

  Fly   298 LALDLLGKMLTFNPHKRIPVEEALAHPYLEQ--------------------YYDPGDEPVAEVPF 342
            .|:.||.:||.|:|.|||..::|||||||::                    .|....|||....|
Mouse   399 EAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKF 463

  Fly   343 RINMENDDISRDALKSLIFEETLKFKERQPDN 374
            ....|.:..|...:|.:|.:..|   |:|..|
Mouse   464 DDTFEKNLSSVRQVKEIIHQFIL---EQQKGN 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	144/347 (41%)
Nlk	NP_032728.3	Required for interaction with TAB2. /evidence=ECO:0000269|PubMed:20194509	1..304		79/161 (49%)
		Sufficient for interaction with DAPK3. /evidence=ECO:0000250|UniProtKB:Q9UBE8	1..125
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..72
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..139
		Sufficient for interaction with DAPK3. /evidence=ECO:0000250|UniProtKB:Q9UBE8	124..416		126/276 (46%)
		STKc_NLK	137..508	CDD:173748	148/357 (41%)
		TQE. /evidence=ECO:0000269|PubMed:15082531, ECO:0000269|PubMed:21118996, ECO:0000269|PubMed:9448268	298..300		1/1 (100%)
		Required for homodimerization and kinase activation and localization to the nucleus. /evidence=ECO:0000269|PubMed:21118996	428..527		13/68 (19%)
		Required for interaction with TAB2. /evidence=ECO:0000269|PubMed:20194509	434..527		13/62 (21%)