Protein Alignment rl and MAPK14

DIOPT Version :10

• Sequence 1: NP_001015122.1
• Gene: rl / 3354888
• FlyBaseID: FBgn0003256
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: XP_011512612.2
• Gene: MAPK14 / 1432
• HGNCID: 6876
• Length: 401
• Species: Homo sapiens
• Alignment Length: 316
• Identity: 158/316 - (50%)
• Similarity: 221/316 - (69%)
• Gaps: 9/316 - (2%)

  Fly    54 SADDTLTNQRVAIKKIS-PFEHQTYCQRTLREITILTRFKHENIIDIRDILR-VDSIDQMRDVYI 116
            :|.||.|..|||:||:| ||:...:.:||.||:.:|...||||:|.:.|:.. ..|:::..|||:
Human    81 AAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYL 145

  Fly   117 VQCLMETDLYKLLKTQRLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDF 181
            |..||..||..::|.|:|::||:.:.:|||||||||||||:::|||||||||.:|:.|:|||.||
Human   146 VTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDF 210

  Fly   182 GLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHY 246
            ||||..|.|      :|.|||||||||||||||...|.:::||||||||:||:|:.|.:|||..:
Human   211 GLARHTDDE------MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDH 269

  Fly   247 LDQLNHILGVLGSPSRDDLECIINEKARNYLESLPFKPNVPWAKLFPNADALALDLLGKMLTFNP 311
            :|||..||.::|:|..:.|:.|.:|.||||::||...|.:.:|.:|..|:.||:|||.|||..:.
Human   270 IDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDS 334

  Fly   312 HKRIPVEEALAHPYLEQYYDPGDEPVAEVPFRINMENDDISRDALKSLIFEETLKF 367
            .|||...:||||.|..||:||.|||||: |:..:.|:.|:..|..|||.::|.:.|
Human   335 DKRITAAQALAHAYFAQYHDPDDEPVAD-PYDQSFESRDLLIDEWKSLTYDEVISF 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	157/313 (50%)
MAPK14	XP_011512612.2	Protein Kinases, catalytic domain	57..391	CDD:473864	158/316 (50%)