DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rl and Mapk1

DIOPT Version :9

Sequence 1:	NP_001015122.1	Gene:	rl / 3354888	FlyBaseID:	FBgn0003256	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_446294.1	Gene:	Mapk1 / 116590	RGDID:	70500	Length:	358	Species:	Rattus norvegicus

Alignment Length:	344	Identity:	283/344 - (82%)
Similarity:	309/344 - (89%)	Gaps:	0/344 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 EVIRGQIFEVGPRYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKISPFEHQTYCQRTLREITILT 89
            |::|||:|:|||||..|:||||||||||.||.|.|...|||||||||||||||||||||||.||.
  Rat    10 EMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILL 74

  Fly    90 RFKHENIIDIRDILRVDSIDQMRDVYIVQCLMETDLYKLLKTQRLSNDHICYFLYQILRGLKYIH 154
            ||:|||||.|.||:|..:|:||:||||||.|||||||||||||.|||||||||||||||||||||
  Rat    75 RFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIH 139

  Fly   155 SANVLHRDLKPSNLLLNKTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYT 219
            |||||||||||||||||.|||||||||||||:|||:|||||||||||||||||||||||||||||
  Rat   140 SANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYT 204

  Fly   220 KSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECIINEKARNYLESLPFKP 284
            ||||||||||||||||||||||||||||||||||||:|||||::||.||||.||||||.|||.|.
  Rat   205 KSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN 269

  Fly   285 NVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYLEQYYDPGDEPVAEVPFRINMEND 349
            .|||.:||||||:.|||||.|||||||||||.||:|||||||||||||.|||:||.||:.:||.|
  Rat   270 KVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELD 334

  Fly   350 DISRDALKSLIFEETLKFK 368
            |:.::.||.||||||.:|:
  Rat   335 DLPKEKLKELIFEETARFQ 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	278/333 (83%)
rl	NP_001015122.1	S_TKc	38..326	CDD:214567	246/287 (86%)
Mapk1	NP_446294.1	STKc_ERK1_2_like	17..351	CDD:270839	278/333 (83%)
		Inhibitor-binding	103..109		4/5 (80%)
		TXY	183..185		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344236
Domainoid	1	1.000	509	1.000	Domainoid score	I311
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37670
Inparanoid	1	1.050	592	1.000	Inparanoid score	I944
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D309855at33208
OrthoFinder	1	1.000	-	-		FOG0000164
OrthoInspector	1	1.000	-	-		otm45936
orthoMCL	1	0.900	-	-		OOG6_100339
Panther	1	1.100	-	-	LDO	PTHR24055
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X259
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760