DRSC/TRiP Functional Genomics Resources

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Protein Alignment rl and Mapk7

DIOPT Version :10

Sequence 1:NP_001015122.1 Gene:rl / 3354888 FlyBaseID:FBgn0003256 Length:376 Species:Drosophila melanogaster
Sequence 2:NP_001178476.1 Gene:Mapk7 / 114509 RGDID:621505 Length:812 Species:Rattus norvegicus


Alignment Length:378 Identity:181/378 - (47%)
Similarity:249/378 - (65%) Gaps:17/378 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 EEFNSSGSVVNGTGSTEVPQSNAEVIRGQ----IFEVGPRYIKLAYIGEGAYGMVVSADDTLTNQ 62
            |..:|:.|||         ..|..:::.:    .|:||..|..:..||.||||:|.||...||.|
  Rat    24 EPVHSAASVV---------AKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQ 79

  Fly    63 RVAIKKI-SPFEHQTYCQRTLREITILTRFKHENIIDIRDILR-VDSIDQMRDVYIVQCLMETDL 125
            :|||||| :.|:..|..:|||||:.||..|||:|||.|:|||| .....:.|.||:|..|||:||
  Rat    80 QVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFRSVYVVLDLMESDL 144

  Fly   126 YKLL-KTQRLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLAR-IAD 188
            :::: .:|.|:.:|:.|||||:||||||:|||.|:||||||||||:|:.|:|||.|||:|| :..
  Rat   145 HQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCT 209

  Fly   189 PEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI 253
            ...:|..|:|||||||||||||:||:...||::||:||||||..|||:.|.:||||:|:.||..|
  Rat   210 SPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLI 274

  Fly   254 LGVLGSPSRDDLECIINEKARNYLESLPFKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVE 318
            :.|||:||...::.:..|:.|.|::|||.:..|||..::|.||..||.|||:||.|.|..||...
  Rat   275 MMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAA 339

  Fly   319 EALAHPYLEQYYDPGDEPVAEVPFRINMENDDISRDALKSLIFEETLKFKERQ 371
            .||.||:|.:|:||.|||....||....:.:.::|:.:|..|..|...|..|:
  Rat   340 AALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARR 392

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rlNP_001015122.1 STKc_ERK1_2_like 32..366 CDD:270839 173/337 (51%)
Mapk7NP_001178476.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Required for cytoplasmic targeting. /evidence=ECO:0000250 2..77 19/61 (31%)
STKc_ERK5 49..384 CDD:270842 172/334 (51%)
Required for binding to MAP2K5. /evidence=ECO:0000250 78..139 31/60 (52%)
Necessary for oligomerization. /evidence=ECO:0000250 140..406 128/253 (51%)
TXY. /evidence=ECO:0000250 219..221 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 424..475
Nuclear localization signal. /evidence=ECO:0000250 505..539
Blue background indicates that the domain is not in the aligned region.

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