Protein Alignment rl and CDK3

DIOPT Version :10

• Sequence 1: NP_001015122.1
• Gene: rl / 3354888
• FlyBaseID: FBgn0003256
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_001249.1
• Gene: CDK3 / 1018
• HGNCID: 1772
• Length: 305
• Species: Homo sapiens
• Alignment Length: 311
• Identity: 119/311 - (38%)
• Similarity: 172/311 - (55%)
• Gaps: 33/311 - (10%)

  Fly    40 KLAYIGEGAYGMVVSADDTLTNQRVAIKKIS-PFEHQTYCQRTLREITILTRFKHENIIDIRDIL 103
            |:..||||.||:|..|.:..|.|.||:|||. ..|.:......:|||::|...||.||:.:.|:
Human     6 KVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDV- 69

  Fly   104 RVDSIDQMRDVYIVQCLMETDLYKLLKT---QRLSNDHICYFLYQILRGLKYIHSANVLHRDLKP 165
                :...|.:|:|...:..||.|.:.:   ..|....|..:|:|:|:|:.:.||..|:||||||
Human    70 ----VHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKP 130

  Fly   166 SNLLLNKTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGC 229
            .|||:|:...:|:.|||||| ...|...:    |..|.|.|||||||:|.||.||.::||||:||
Human   131 QNLLINELGAIKLADFGLARAFGVPLRTY----THEVVTLWYRAPEILLGSKFYTTAVDIWSIGC 191

  Fly   230 ILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECIINEKARNYLESLP-FKPNVP-WAK-- 290
            |.|||::.:.:|||...:|||..|..:||:||.|....:         ..|| :|.:.| |.:
Human   192 IFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGV---------TQLPDYKGSFPKWTRKG 247

  Fly   291 ---LFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYLEQYYDPGDEPVA 338
               :.||.:....|||.::|.::|.:||..:.||||||   :..|...|.|
Human   248 LEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPY---FSSPEPSPAA 295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	119/311 (38%)
CDK3	NP_001249.1	STKc_CDK2_3	3..286	CDD:270844	116/300 (39%)