Protein Alignment rl and CDK2

DIOPT Version :10

• Sequence 1: NP_001015122.1
• Gene: rl / 3354888
• FlyBaseID: FBgn0003256
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: XP_011536034.1
• Gene: CDK2 / 1017
• HGNCID: 1771
• Length: 346
• Species: Homo sapiens
• Alignment Length: 353
• Identity: 118/353 - (33%)
• Similarity: 170/353 - (48%)
• Gaps: 78/353 - (22%)

  Fly    40 KLAYIGEGAYGMVVSADDTLTNQRVAIKKIS-PFEHQTYCQRTLREITILTRFKHENIIDIRDIL 103
            |:..||||.||:|..|.:.||.:.||:|||. ..|.:......:|||::|....|.||:.:.|::
Human     6 KVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVI 70

  Fly   104 RVDSIDQMRDVYIVQCLMETDLYKLLKTQRLSN---DHICYFLYQILRGLKYIHSANVLHRDLKP 165
            ..::     .:|:|...:..||.|.:....|:.   ..|..:|:|:|:||.:.||..||||||||
Human    71 HTEN-----KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKP 130

  Fly   166 SNLLLNKTCDLKICDFGLAR-IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGC 229
            .|||:|....:|:.|||||| ...|...:    |..|.|.|||||||:|..|.|:.::||||:||
Human   131 QNLLINTEGAIKLADFGLARAFGVPVRTY----THEVVTLWYRAPEILLGCKYYSTAVDIWSLGC 191

  Fly   230 ILAEM------------------------------------------------LSNRPIFPGKHY 246
            |.|||                                                ::.|.:|||...
Human   192 IFAEMHLVGTQHHARCCGEHRRNGRQSLCPLCSYLEVAASQGWGMTAVSTPYPVTRRALFPGDSE 256

  Fly   247 LDQLNHILGVLGSPSRDDLECIINEKARNYLESLP-FKPNVP-WA-----KLFPNADALALDLLG 304
            :|||..|...||:|         :|.....:.|:| :||:.| ||     |:.|..|.....||.
Human   257 IDQLFRIFRTLGTP---------DEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLS 312

  Fly   305 KMLTFNPHKRIPVEEALAHPYLEQYYDP 332
            :||.::|:|||..:.|||||:.:....|
Human   313 QMLHYDPNKRISAKAALAHPFFQDVTKP 340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	118/353 (33%)
CDK2	XP_011536034.1	STKc_CDK2_3	3..334	CDD:270844	117/345 (34%)