DRSC/TRiP Functional Genomics Resources

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Protein Alignment klhl10 and KLHL21

DIOPT Version :10

Sequence 1:NP_001015100.2 Gene:klhl10 / 3354863 FlyBaseID:FBgn0040038 Length:767 Species:Drosophila melanogaster
Sequence 2:NP_055666.2 Gene:KLHL21 / 9903 HGNCID:29041 Length:597 Species:Homo sapiens


Alignment Length:566 Identity:140/566 - (24%)
Similarity:232/566 - (40%) Gaps:92/566 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 AHTKSLAPIVSDEALNTLNELREQNLLCDAQISV--GEDVFNVHRAIMCSCSSYFRAQFTGFNAD 117
            ||..||        |..|::||.:....|..:..  |.| |..|||::.:.|.||||.|.|...:
Human    16 AHALSL--------LRGLSQLRAERKFLDVTLEAAGGRD-FPAHRAVLAAASPYFRAMFAGQLRE 71

  Fly   118 TPGCVDGSDAKKNNNFIHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLVKKC 182
                   |.|::    :.:.||...::..::.::|..:..:|..|...||..||.:....:.:.|
Human    72 -------SRAER----VRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEAC 125

  Fly   183 KDYLGRILTPENCVSIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNIDILDMSAEDFYSIISDD 247
            ..:|.:.|...||:.:..||.......|...|:.:.||:..|:....::.|.::.  ....:.||
Human   126 GAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLAR--LLRYLRDD 188

  Fly   248 ELNTREEDHVWKLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYVLECEAAKPL 312
            .|...:|:..::|.::|:..:|..|..|...|:..|||..:.....:..|:..|.|..|.....|
Human   189 GLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRL 253

  Fly   313 IVDTFKFM---YDLDFLNPQADELTTPPLAMPRLPHEVIFAIGGWSGGTSKGC-----IETYDTR 369
            :.:...|.   ||.....|       .|...|| |...:..|....||..:.|     ::.|:.:
Human   254 LREARDFQAARYDRHDRGP-------CPRMRPR-PSTGLAEILVLVGGCDQDCDELVTVDCYNPQ 310

  Fly   370 ADRWVTINAEDPAGPRAYHGTAVLGFKIFSIGGYDGVEYFNTCRVFDAVKKKWNEIAPMHCRRCY 434
            ..:|..: ||.|......:....||..|:..||.||...::....:::...:|.|:|||...|.|
Human   311 TGQWRYL-AEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREY 374

  Fly   435 VSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQRSDASACTLQERIYATGGFNG 499
            .|.:.|:|::|.:..       ::.|||:..|:.|..:.||.....:.|....:.|:||.|...|
Human   375 HSSSVLDGLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAG 432

  Fly   500 QECL-----------------------------------------DSAE--YYDPVTNVWTRIPN 521
            :|.:                                         ||||  .|:|..|.|.:||:
Human   433 KETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAEVDVYNPTRNEWDKIPS 497

  Fly   522 MNHRRSGVSCVAFRNQLYVIGGFNGTARLS-TGERFDPDTQTWHFI 566
            ||....|.|......:|||.||::.|..|| ..|.:||:|:.|..:
Human   498 MNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVV 543

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
klhl10NP_001015100.2 BTB_POZ 62..>108 CDD:453885 13/47 (28%)
PHA03098 86..610 CDD:222983 131/535 (24%)
KELCH repeat 385..428 CDD:276965 10/42 (24%)
KELCH repeat 432..475 CDD:276965 11/42 (26%)
KELCH repeat 479..523 CDD:276965 17/86 (20%)
KELCH repeat 526..571 CDD:276965 15/42 (36%)
KELCH repeat 573..617 CDD:276965
KLHL21NP_055666.2 BTB_POZ_KLHL21 14..138 CDD:349559 36/141 (26%)
PHA03098 49..547 CDD:222983 128/524 (24%)
BACK_KLHL21 133..232 CDD:350535 24/100 (24%)
Kelch 1 287..335 10/48 (21%)
KELCH repeat 326..368 CDD:276965 10/41 (24%)
Kelch 2 336..382 14/45 (31%)
KELCH repeat 372..409 CDD:276965 12/43 (28%)
Kelch 3 384..422 9/44 (20%)
KELCH repeat 412..451 CDD:276965 7/38 (18%)
Kelch 4 423..470 6/46 (13%)
Kelch 5 472..512 14/39 (36%)
KELCH repeat 502..548 CDD:276965 15/42 (36%)
Kelch 6 513..560 13/31 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 570..597
Blue background indicates that the domain is not in the aligned region.

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