Protein Alignment klhl10 and KEAP1

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_036421.2
• Gene: KEAP1 / 9817
• HGNCID: 23177
• Length: 624
• Species: Homo sapiens
• Alignment Length: 596
• Identity: 177/596 - (29%)
• Similarity: 281/596 - (47%)
• Gaps: 59/596 - (9%)

  Fly    48 GRKTI---LNAHTKSLAPIVSDEALNTLNELREQNLLCDAQISVG-EDV----FNVHRAIMCSCS 104
            |.:|.   |..|||        :|...:||||....|||..:.|. :|.    |..|:.::.|.|
Human    48 GNRTFSYTLEDHTK--------QAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSS 104

  Fly   105 SYFRAQFT-GFNADTPGCVDGSDAKKNNNFIHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLI 168
            ..|:|.|| |..            ::....:.|.|:...:|..:|::||....::.|..|..::.
Human   105 PVFKAMFTNGLR------------EQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMN 157

  Fly   169 CADYVGMVGLVKKCKDYLGRILTPENCVSIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNIDIL 233
            .|....:..:|:.|.|:|.:.|.|.|.:.|..||......:||.:||.|...:|.||| :..:..
Human   158 GAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVA-KQEEFF 221

  Fly   234 DMSAEDFYSIISDDELNTREEDHVWKLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVK 298
            ::|.....::||.|:||.|.|..|:..|:.|:..:.|.|:.:|..|:..||...:||.....:::
Human   222 NLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQ 286

  Fly   299 EHPYVLECEAAKPLIVDTFKFMYDLDFLNPQADELT--TPPLAMP-RLPH--EVIFAIGGWSGGT 358
            :...:......|..:|..|             :|||  .|...|| |.|.  .:|:..||:. ..
Human   287 KCEILQSDSRCKDYLVKIF-------------EELTLHKPTQVMPCRAPKVGRLIYTAGGYF-RQ 337

  Fly   359 SKGCIETYDTRADRWVTINAEDPAGPRAYHGTAVLGFKIFSIGGYDGVEYFNT------CRVFDA 417
            |...:|.|:.....|:.:  .|...||:.....|:|..::::||.:.....||      |  ::.
Human   338 SLSYLEAYNPSDGTWLRL--ADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDC--YNP 398

  Fly   418 VKKKWNEIAPMHCRRCYVSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQRSDA 482
            :..:|:..|||...|..:.|..::|.|||:||..|....|:||||.|..::|.::.||..:|...
Human   399 MTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGV 463

  Fly   483 SACTLQERIYATGGFNGQECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFNGT 547
            ....|...:||.|||:|...|:|||.|.|..|.|..|..||..|||.......|.:|..||::|.
Human   464 GVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQ 528

  Fly   548 ARLSTGERFDPDTQTWHFIREMNHSRSNFGLEIIDDMIFAIGGFNGVSTISHTECYVAETDEWME 612
            .:|::.||:|.:|:||.|:..|.|.||..|:.:....|:.:||::|.:.:...|||..:||.|.|
Human   529 DQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSE 593

  Fly   613 ATDMNIVRSAL 623
            .|.|...||.:
Human   594 VTRMTSGRSGV 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	14/50 (28%)
		PHA03098	86..610	CDD:222983	157/540 (29%)
		KELCH repeat	385..428	CDD:276965	10/48 (21%)
		KELCH repeat	432..475	CDD:276965	16/42 (38%)
		KELCH repeat	479..523	CDD:276965	17/43 (40%)
		KELCH repeat	526..571	CDD:276965	17/44 (39%)
		KELCH repeat	573..617	CDD:276965	15/43 (35%)
KEAP1	NP_036421.2	BTB_POZ_KLHL19_KEAP1	56..180	CDD:349557	36/143 (25%)
		PHA03098	95..596	CDD:222983	156/531 (29%)
		Kelch 1	327..372		11/47 (23%)
		KELCH repeat	362..409	CDD:276965	10/48 (21%)
		Kelch 2	373..423		11/51 (22%)
		KELCH repeat	413..456	CDD:276965	16/42 (38%)
		Kelch 3	424..470		17/45 (38%)
		KELCH repeat	460..503	CDD:276965	17/42 (40%)
		Kelch 4	471..517		20/45 (44%)
		KELCH repeat	507..551	CDD:276965	16/43 (37%)
		Kelch 5	518..564		17/45 (38%)
		KELCH repeat	554..597	CDD:276965	15/42 (36%)
		Kelch 6	565..611		15/40 (38%)