Protein Alignment klhl10 and KLHL6

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_569713.2
• Gene: KLHL6 / 89857
• HGNCID: 18653
• Length: 621
• Species: Homo sapiens
• Alignment Length: 626
• Identity: 159/626 - (25%)
• Similarity: 277/626 - (44%)
• Gaps: 87/626 - (13%)

  Fly    57 TKSLAPIVSDEAL------------NTLNELREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRA 109
            |..|..|::.|.:            |.|..||.:|.|.|..:.|....|:.||.::.:.|:||||
Human    35 TGDLVEILNGEKVKFDDAGLSLILQNGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRA 99

  Fly   110 QFTGFNADTPGCVDGSDAKKNNNFIHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVG 174
            .|         |.|..:  |....|.|.||.:..|:.::.|.|..:..|::.||..:|..|:...
Human   100 MF---------CNDLKE--KYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQ 153

  Fly   175 MVGLVKKCKDYLGRILTPENCVSIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNIDILDMSAED 239
            .:.:|..|..:|...|.|||||.|:..|....|:.|..:.::|.::.|.:: ..:.:.||:..:.
Human   154 FLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQI-LNSEEFLDLPVDT 217

  Fly   240 FYSIISDDELNTREEDHVWKLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYVL 304
            .:.|:..|:|...||..|::..:.|:...|..|...:.:::..|||.|:.|..|:|.|:..|.:.
Human   218 LHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIR 282

  Fly   305 ECEAAKPLIVDTFKFMYDLDFLNPQADELTTPPLAMPRLPHEVIFAIGGWSGGTSKGCIETYDTR 369
            :|....||:.:.  .||.|.. |....|.|.|  .|.....||...||        ||     |:
Human   283 QCPEVFPLLQEA--RMYHLSG-NEIISERTKP--RMHEFQSEVFMIIG--------GC-----TK 329

  Fly   370 ADRWVT-INAEDPAG---------PRAYH------------GTAVLGFKIFSIGG----YDGVEY 408
            .:|:|. :...||..         |...|            ....|..:::..||    :|..:|
Human   330 DERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWKY 394

  Fly   409 FNTCRVFDAVKKKWNEIAPMHCRRCYVSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIP 473
            .::.       .||.:|..::..|....:..|.|.:|.|||:||..|:|.||.|:|..|.||...
Human   395 NSSI-------NKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAA 452

  Fly   474 PMNMQRSDASACTLQERIYATGGF-NGQECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQ 537
            |:.:..|..:|.:.::::|..||. ||:...|..:.|||.||.|:....|......::.|:||::
Human   453 PLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDR 517

  Fly   538 LYVIGGFNGTARLSTGERFDPDTQTWHFIREMNHSRSNFGLEIIDDMIFAIGGFNGVSTISHTE- 601
            :||:||     .:.....:.|...:|..:.:::|.|::.|:...::.::..||.:..:.:..|.
Human   518 IYVVGG-----AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVL 577

  Fly   602 CYVAETDEWMEATDMNIVRSALSANNIAGLPNKRDYIHKER 642
            |:..|.   .:.|:..::...:|.:....:  ::.|.|..|
Human   578 CWDPEA---QKLTEECVLPRGVSHHGSVTI--RKSYTHIRR 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	15/57 (26%)
		PHA03098	86..610	CDD:222983	143/551 (26%)
		KELCH repeat	385..428	CDD:276965	9/58 (16%)
		KELCH repeat	432..475	CDD:276965	18/42 (43%)
		KELCH repeat	479..523	CDD:276965	14/44 (32%)
		KELCH repeat	526..571	CDD:276965	9/44 (20%)
		KELCH repeat	573..617	CDD:276965	8/44 (18%)
KLHL6	NP_569713.2	BTB_POZ_KLHL6	48..176	CDD:349545	40/138 (29%)
		PHA03098	86..565	CDD:222983	136/520 (26%)
		BACK_KLHL6	169..276	CDD:350521	30/107 (28%)
		Kelch 1	320..367		12/59 (20%)
		KELCH repeat	370..407	CDD:276965	8/43 (19%)
		Kelch 2	378..421		9/49 (18%)
		KELCH repeat	411..455	CDD:276965	19/43 (44%)
		Kelch 3	422..468		18/45 (40%)
		KELCH repeat	458..504	CDD:276965	15/45 (33%)
		Kelch 4	470..516		15/45 (33%)
		KELCH repeat	506..546	CDD:276965	9/44 (20%)
		Kelch 5	517..558		9/45 (20%)
		KELCH repeat	548..593	CDD:276965	8/47 (17%)
		Kelch_1	548..585	CDD:396078	7/39 (18%)
		Kelch 6	560..606		7/50 (14%)