DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klhl10 and AFR

DIOPT Version :9

Sequence 1:	NP_001015100.2	Gene:	klhl10 / 3354863	FlyBaseID:	FBgn0040038	Length:	767	Species:	Drosophila melanogaster
Sequence 2:	NP_565572.1	Gene:	AFR / 816990	AraportID:	AT2G24540	Length:	372	Species:	Arabidopsis thaliana

Alignment Length:	310	Identity:	74/310 - (23%)
Similarity:	125/310 - (40%)	Gaps:	58/310 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 PHEVIFAIGGWSGGTSKGCIETYDTRADRWVTINAEDPAGPRAY------HGTAVLGF----KIF 398
            |:..:||   ::..|::...::.|..:.||..:    |..|.::      |..:....    |:|
plant    80 PYLFVFA---FNKSTARIQWQSLDLASGRWFVL----PPMPNSFTKISSPHALSCASMPRQGKLF 137

  Fly   399 SIGGYDGVEYFNTCRVFDAVKKKWNEIAPMHCRRCYVSVTELNGMIYAIGGYDGHNRLNT--VER 461
            .:||.|   ...:..|:.|:..:|:.|:||...|.|.....:||.|.|:||..|.|...|  ||.
plant   138 VLGGGD---VNRSAVVYTALTNRWSCISPMMSPRTYFVSGNVNGKIMAVGGSVGGNGEATTEVES 199

  Fly   462 YNPRTNQWSVIPPMNMQRSDASACTLQERIYATGGF--------NGQECLDSAEYYDPVTNVWTR 518
            |:|..:.|:|:..:.|..:...:..:.:.:..|.|:        .||       .||.....|..
plant   200 YDPDNDTWTVVKKLPMVLAKYDSAVIGKEMCVTEGWAWPFMFPPMGQ-------VYDSDEGTWRE 257

  Fly   519 IP-NMNHRRSGVSCVAFRNQLYVI---GGFNGTARLSTGERFDPDTQTWHFIR----EMNHSRSN 575
            :. .|....:||| |..|::|:||   |.|......|       |..||.::.    :....|..
plant   258 MSGGMKEGWTGVS-VVIRDRLFVISEHGDFPMKVYCS-------DDDTWRYVSGEKLQGEKMRRP 314

  Fly   576 FGLEIIDDMIFAIGGFNGVSTISHTECYVAETDEWMEATDMNIVRSALSA 625
            |.:...||.:|.:     .|.|:..|..|:|......:.:..:|.|..|:
plant   315 FAVTGADDRVFVV-----ASGINVAEGRVSEGQNGDFSVEWRMVSSPKSS 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB	72..186	CDD:279045
		PHA03098	86..610	CDD:222983	71/293 (24%)
		BACK	195..298	CDD:285009
		Kelch	347..394	CDD:128874	9/52 (17%)
		KELCH repeat	385..428	CDD:276965	10/52 (19%)
		Kelch	396..442	CDD:128874	13/45 (29%)
		Kelch_1	431..476	CDD:279660	17/46 (37%)
		KELCH repeat	432..475	CDD:276965	17/44 (39%)
		KELCH repeat	479..523	CDD:276965	7/52 (13%)
		Kelch	490..536	CDD:128874	12/54 (22%)
		Kelch_1	525..570	CDD:279660	14/51 (27%)
		KELCH repeat	526..571	CDD:276965	14/51 (27%)
		Kelch_1	573..617	CDD:279660	10/43 (23%)
		KELCH repeat	573..617	CDD:276965	10/43 (23%)
AFR	NP_565572.1	F-box	27..72	CDD:279040
		Kelch_1	167..214	CDD:279660	17/46 (37%)
		KELCH repeat	168..214	CDD:276965	17/45 (38%)
		KELCH repeat	217..259	CDD:276965	7/48 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1072
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	57	1.000	Inparanoid score	I2576
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.860