Protein Alignment klhl10 and KLHL36

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_079007.2
• Gene: KLHL36 / 79786
• HGNCID: 17844
• Length: 616
• Species: Homo sapiens
• Alignment Length: 633
• Identity: 145/633 - (22%)
• Similarity: 259/633 - (40%)
• Gaps: 91/633 - (14%)

  Fly    65 SDEALNTLNELREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRAQFTGFNADTPGCVDGSDAKK 129
            |...|..|||.|.:.|.||..:...|.....||.::..||.||.:.||         :...:|.:
Human    29 SSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFT---------IGMREAFQ 84

  Fly   130 NNNFIHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLGRILTPEN 194
            ..  :.:.|.|...:..|:.:.|..:..:...|:..:|..|..:.:..:|..|.:||.:.::.:|
Human    85 KE--VELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147

  Fly   195 CVSIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNIDILDMSAEDFYSIISDDELNTREEDHVWK 259
            .:.:...|....|:.|......:.|.:|..:::....:.::|.:.....:|..|:....|..:.:
Human   148 YLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRECEHDLLQ 212

  Fly   260 LCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKEH-----PYVLECE------------ 307
            ..::|:.:.|| |:.|...::..:...|:.....:..||..     |....||
Human   213 AALQWLTQQPE-REAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEGFIEEAVRYHNN 276

  Fly   308 -AAKPLIVDTFKFMYDLDFLNPQADELTTPPLAMPRLPHEVIFAIGGWSGGTSKGCIET------ 365
             ||:|:                    :.|...|: |...|.:..:|   |..|:.|:|.
Human   277 LAAQPV--------------------MQTKRTAL-RTNQERLLFVG---GEVSERCLELSDDTCY 317

  Fly   366 YDTRADRWVTINAEDP-AGPRAYHGTAVLGFKIFSIGG-----YDGVEYFNTCRVFDAVKKKWNE 424
            .|.::::||   .|.| ...|::|..||||..||..||     ..|....|....:|...|:|.:
Human   318 LDAKSEQWV---KETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIK 379

  Fly   425 IAPMHCRRCYVSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQRSDASACTLQE 489
            :|.|:.||....:..:..|:.||||.:.:..|::||.|:|:|:.||.:..:.......:....::
Human   380 VASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKD 444

  Fly   490 RIYATGGFNGQECLDSAEY------YDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFNGTA 548
            .:|.:||.:.|    ...|      ||..|:||.....|...|...|..:..:.:|.|||.:.
Human   445 FVYISGGHDYQ----IGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDD-- 503

  Fly   549 RLSTGERFD--------PDTQTWHFIREMNHSRSNFGLEIIDDMIFAIGGFNGVST-ISHT-ECY 603
            .:.:.||||        |....|..:..:.|:.|..|:.:.:..|:.:||::..:| .|.| :.|
Human   504 NIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSKTVQVY 568

  Fly   604 VAETDEWMEATDMNIVRSALSANNIAGLPNKRDYIHKERDRLMEERRQ 651
            ..|.|:|....|:....:..||...|..|...|...|.:.:..::|.|
Human   569 DREADKWSRGVDLPKAIAGGSACVCALEPRPEDKKKKGKGKRHQDRGQ 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	15/42 (36%)
		PHA03098	86..610	CDD:222983	126/569 (22%)
		KELCH repeat	385..428	CDD:276965	16/47 (34%)
		KELCH repeat	432..475	CDD:276965	14/42 (33%)
		KELCH repeat	479..523	CDD:276965	10/49 (20%)
		KELCH repeat	526..571	CDD:276965	12/52 (23%)
		KELCH repeat	573..617	CDD:276965	13/45 (29%)
KLHL36	NP_079007.2	BTB_POZ_KLHL36	21..155	CDD:349575	31/136 (23%)
		BACK_KLHL36	143..242	CDD:350550	16/99 (16%)
		Kelch 1	296..345		15/54 (28%)
		NanM	324..592	CDD:442289	75/276 (27%)
		KELCH repeat	335..383	CDD:276965	16/47 (34%)
		Kelch 2	346..397		13/50 (26%)
		KELCH repeat	387..431	CDD:276965	14/43 (33%)
		Kelch 3	398..444		13/45 (29%)
		KELCH repeat	434..481	CDD:276965	11/50 (22%)
		Kelch 4	446..493		13/50 (26%)
		KELCH repeat	483..533	CDD:276965	12/51 (24%)
		Kelch 5	494..546		13/53 (25%)
		KELCH repeat	536..582	CDD:276965	13/45 (29%)
		Kelch 6	547..595		13/47 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	597..616		4/18 (22%)