Protein Alignment klhl10 and Klhl40

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_082478.1
• Gene: Klhl40 / 72330
• MGIID: 1919580
• Length: 621
• Species: Mus musculus
• Alignment Length: 603
• Identity: 141/603 - (23%)
• Similarity: 239/603 - (39%)
• Gaps: 124/603 - (20%)

  Fly    72 LNELREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRAQFTGFNADTPGCVDGSDAKKNNNFIHI 136
            |.::.:.....|..:.|||..|..||.::.:||.||||:|.. ..|:.|            .:.:
Mouse    23 LKDMLDHGKFLDCVVRVGEREFPCHRLVLAACSPYFRARFLA-EPDSAG------------EVRL 74

  Fly   137 PGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLGRILTPENCVSIMGF 201
            ..||..:::.|:.|.|..:..:.|::|.:|...|....:..:...|..:|.:.|...||:::.
Mouse    75 EEVSPDVVSQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLANCLAVF-- 137

  Fly   202 ARFRFLED---LHLKARNYTLRYFTEVAYRNIDILDMSAEDFYSIISDDELNTREEDHVWKLCVK 263
             |...|.|   |.:.||::....|..|| |:.|.|.:||::..:|||.|.||..:|:.|::..::
Mouse   138 -RLGLLLDCARLAVAARDFICARFPLVA-RDNDFLGLSADELIAIISSDGLNVEKEEAVFEAVMR 200

  Fly   264 WI---DRNPES-RKRHVAHLMTGVRLGLMTPKCFME-EVKEHPYVL------------------- 304
            |.   |...:: |:|.:..:...||..|: |:.|:| .|:.||.|.
Mouse   201 WASSGDAEAQAERQRALPTVFESVRCRLL-PRAFLETRVERHPLVRSQPELLRKVQMVKDAHEGR 264

  Fly   305 --------------------------------ECEAAKP-LIVDTFK---FMYDLDFL------- 326
                                            :.|...| ::.||.:   |:.||.|:
Mouse   265 LTTLRKKKKEKGEQTARAKEANQGTEDTKAEDDEERVLPGILNDTLRFGMFLQDLIFMISEEGAV 329

  Fly   327 --NPQADELTTPPLA--MPR------LPHEVIFAIGG--WSGGTSKGCIETYDTRAD----RWVT 375
              :|.|:|.....|:  :|:      .....:|..||  ::....:..:..|..:.|    .|
Mouse   330 AYDPAANECYCASLSTQIPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHLDSEW-- 392

  Fly   376 INAEDPAGPRAYHGTAVLGFKIFSIGG---YDGVEYFNTCRVFDAVKKKWNEIAPMHCRRCYVSV 437
            :.......||...|.......|:.:||   .|..:..::...:|.:..||.|..|:.......:|
Mouse   393 LGMPPLPSPRCLFGLGEALNAIYVVGGRELKDSEDSLDSVLCYDRLSFKWGESDPLPYAVYGHTV 457

  Fly   438 TELNGMIYAIGGYDGHNR--LNTVERYNPRTNQWSVIPPMNMQRSDASACTLQERIYATGGFNGQ 500
            .....::|.||| .|.:|  ||.:..|:|:..:|..:.||...||...|.....||:...|....
Mouse   458 LSHMDLVYVIGG-KGKDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIFVAAGVTDT 521

  Fly   501 ECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFNGTARLSTGE----------R 555
            ....|:|.|....|.||........||.:|.|:....||.:||| .|....:||          |
Mouse   522 GLTSSSEVYSIADNKWTSFEAFPQERSSLSLVSLAGTLYALGGF-ATLETESGELVPTELNDIWR 585

  Fly   556 FDPDTQTWH-FIREMNHS 572
            ::.|.:.|. .:||:.::
Mouse   586 YNEDEKKWEGVLREIAYA 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	11/35 (31%)
		PHA03098	86..610	CDD:222983	139/589 (24%)
		KELCH repeat	385..428	CDD:276965	10/45 (22%)
		KELCH repeat	432..475	CDD:276965	12/44 (27%)
		KELCH repeat	479..523	CDD:276965	12/43 (28%)
		KELCH repeat	526..571	CDD:276965	17/55 (31%)
		KELCH repeat	573..617	CDD:276965	141/603 (23%)
Klhl40	NP_082478.1	BTB_POZ	6..137	CDD:453885	31/126 (25%)
		PHA03098	47..594	CDD:222983	132/568 (23%)
		BACK	128..230	CDD:475122	32/106 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	265..298		0/32 (0%)
		KELCH repeat	351..398	CDD:276965	6/48 (13%)
		Kelch 1. /evidence=ECO:0000255	360..412		9/53 (17%)
		KELCH repeat	402..448	CDD:276965	10/45 (22%)
		Kelch 2. /evidence=ECO:0000255	413..462		10/48 (21%)
		KELCH repeat	452..497	CDD:276965	13/45 (29%)
		Kelch 3. /evidence=ECO:0000255	463..510		16/47 (34%)
		KELCH repeat	500..545	CDD:276965	12/44 (27%)
		Kelch 4. /evidence=ECO:0000255	512..557		12/44 (27%)
		KELCH repeat	547..594	CDD:276965	14/47 (30%)
		Kelch 5. /evidence=ECO:0000255	559..613		13/46 (28%)