Protein Alignment klhl10 and Klhl28

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_079983.1
• Gene: Klhl28 / 66689
• MGIID: 1913939
• Length: 571
• Species: Mus musculus
• Alignment Length: 572
• Identity: 161/572 - (28%)
• Similarity: 277/572 - (48%)
• Gaps: 38/572 - (6%)

  Fly    59 SLAPIVSDEALNTLNELREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRAQFTGFNADTPGCVD 123
            :|..:.|::.|..||.||:.:.|||..:.||:...:.|:.::.|.|.||:|.||
Mouse    12 NLTHLHSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASISPYFKAMFT----------- 65

  Fly   124 GSDAKKNNNFIHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLGR 188
            |:.::|.|:.:....:....:..:::|||.....||:..|..||..|:.:.:..::|:|..:|..
Mouse    66 GNLSEKENSEVEFQCIDEAALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLES 130

  Fly   189 ILTPENCVSIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNIDILDMSAEDFYSIISDDELNTRE 253
            .|.|.||:.|..||......||:|.|..:..:.|..|. :..:..:::..|...|:|:|.||...
Mouse   131 QLDPGNCIGISRFAETYGCHDLYLAATKFICQNFESVC-QTEEFFELTHADLDEIVSNDCLNVAT 194

  Fly   254 EDHVWKLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYVLECEAAKPLIVDTFK 318
            |:.|:.....||..:.:.|::::|.|:..|||.|::.|......:.:..:.:....|.|:.:..|
Mouse   195 EETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALK 259

  Fly   319 FMYDLDFLNPQADELTTPPLAMPRLPHEVIFAIGGWSGGTSKGC---IETYDTRADRWV---TIN 377
            :    .|:........|..:..||...:|:.|:||.||  ...|   :|.|..:.|.|:   .:|
Mouse   260 Y----HFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSG--LFACLDSVEMYFPQNDSWIGLAPLN 318

  Fly   378 AEDPAGPRAYHGTAVLGFKIFSIGGYD-----GV---EYFNTCRVFDAVKKKWNEIAPMHCRRCY 434
            .     ||...|..||..|:|.|||.:     |:   ::.|:...::.....|..:..|:..|..
Mouse   319 I-----PRYEFGICVLDQKVFVIGGIETSVRPGMTVRKHENSVECWNPDTNTWTSLERMNESRST 378

  Fly   435 VSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQRSDASACTLQERIYATGGFNG 499
            :.|..|.|.::|:|||||.:.|.:||:|.|:..||..:.||...||..:|..|...:||.||: |
Mouse   379 LGVAVLAGEVFALGGYDGQSYLQSVEKYIPKIRQWQPVAPMTTTRSCFAAAVLDGMLYAIGGY-G 442

  Fly   500 QECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFNGTARLSTGERFDPDTQTWH 564
            ...::|.|.|||..:.|..:..|..:|...........::|:||.||.:.||:.||:||....|.
Mouse   443 PAHMNSVERYDPSKDSWEMVAPMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQWT 507

  Fly   565 FIREMNHSRSNFGLEIIDDMIFAIGGFNGVSTISHTECYVAETDEWMEATDM 616
            ..|.|...|:..|..:||:.::.:||.:|.|.::..:.|...:|.|:::..|
Mouse   508 VCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGM 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	15/45 (33%)
		PHA03098	86..610	CDD:222983	149/537 (28%)
		KELCH repeat	385..428	CDD:276965	12/50 (24%)
		KELCH repeat	432..475	CDD:276965	17/42 (40%)
		KELCH repeat	479..523	CDD:276965	15/43 (35%)
		KELCH repeat	526..571	CDD:276965	15/44 (34%)
		KELCH repeat	573..617	CDD:276965	12/44 (27%)
Klhl28	NP_079983.1	PHA03098	35..553	CDD:222983	151/541 (28%)
		Kelch 1	284..331		17/53 (32%)
		KELCH repeat	321..372	CDD:276965	12/50 (24%)
		Kelch 2	332..386		12/53 (23%)
		KELCH repeat	376..419	CDD:276965	17/42 (40%)
		Kelch 3	387..433		19/45 (42%)
		KELCH repeat	423..465	CDD:276965	15/42 (36%)
		Kelch 4	435..479		13/44 (30%)
		KELCH repeat	469..513	CDD:276965	14/43 (33%)
		Kelch 5	480..526		17/45 (38%)
		KELCH repeat	516..559	CDD:276965	11/42 (26%)
		Kelch 6	528..570		8/32 (25%)