Protein Alignment klhl10 and KLHL14

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_065856.1
• Gene: KLHL14 / 57565
• HGNCID: 29266
• Length: 628
• Species: Homo sapiens
• Alignment Length: 615
• Identity: 144/615 - (23%)
• Similarity: 251/615 - (40%)
• Gaps: 80/615 - (13%)

  Fly    57 TKSLAPIVSDEALNTLNELREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRAQFT--------- 112
            |.:..|..||..|:.||.|..:.|.||..::.....|:.|:|::.|||.|||:.|:
Human     8 TSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGV 72

  Fly   113 ----GFNA---------------------DTPGCVDGSDAKK-------NNNFIHIPGVSSCIMN 145
                |..|                     :.||....|...|       .||.: :.|.||..:.
Human    73 GGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLV-LQGCSSIGLR 136

  Fly   146 CVIQYAYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLGRILTPENCVSIMGFARFRFLEDL 210
            .|::|.|.....:|...|.|:|..:..:.:..:.|.|..:|...::.:|...:...|....||:.
Human   137 LVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHGLEET 201

  Fly   211 HLKARNYTLRYFTEVAYRNIDILDMSAEDFYSIISDDELNTREEDHVWKLCVKWIDRNPESRKRH 275
            ...|..|.:.          |:|.::.|:..:::.........|..::::.|.|::.:.|:|.::
Human   202 KKLANKYLVE----------DVLLLNFEEMRALLDSLPPPVESELALFQMSVLWLEHDRETRMQY 256

  Fly   276 VAHLMTGVRLGLMTPKCFMEEVKEHPYVLECEAAKPLIVDTFKFMYDLDFLNPQADELTTPPLAM 340
            ...||..:|..|:.....:|.|:...::......:.|::|...:     .|.|..........:.
Human   257 APDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNY-----HLMPFRQHCRQSLASR 316

  Fly   341 PRLPHEVIFAIGGWSGGTSK---GCIETYDTRADRW--VTINAEDPAGPRAYHGTAVLGFKIFSI 400
            .|...:::..:||...|..:   ..::.||.....|  :||...:    .|:|....:...:|.:
Human   317 IRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYN----SAHHCVVEVENFLFVL 377

  Fly   401 GGYD-----GVEYFNTCRVFDAVKKKWNEIAPMHCRRCYVSVTELNGMIYAIGGYDGHNRLNTVE 460
            ||.|     |....|....:|.....|.::.||..||.......|:..:|.|||.:....|::||
Human   378 GGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVE 442

  Fly   461 RYNPRTNQWSVIPPMNMQRSDASACTLQERIYATGGFNGQECLDSAEYYDPVTNVWTRIPNMNHR 525
            .||..||:|..:..:....:..:......:||.:||.:..|.:.....||||.:||.|..:||.:
Human   443 CYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTK 507

  Fly   526 RSGVSCVAFRNQLYVIGG--FNGTARLST--GERFDPDTQTWHFIR-EMNHSRSNFGLEIIDDMI 585
            |:..:.....::||.|||  ..|.:.|..  .|.:||....|:.:: .:...||..|..::||.|
Human   508 RAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSI 572

  Fly   586 FAIGGFN---GVSTISHTECYVAETDEWME 612
            :.:||::   |... |.|.||..|...|.|
Human   573 YLVGGYSWSMGAYK-SSTICYCPEKGTWTE 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	17/45 (38%)
		PHA03098	86..610	CDD:222983	131/582 (23%)
		KELCH repeat	385..428	CDD:276965	10/47 (21%)
		KELCH repeat	432..475	CDD:276965	14/42 (33%)
		KELCH repeat	479..523	CDD:276965	12/43 (28%)
		KELCH repeat	526..571	CDD:276965	12/49 (24%)
		KELCH repeat	573..617	CDD:276965	16/43 (37%)
KLHL14	NP_065856.1	BTB_POZ_KLHL14_printor	1..188	CDD:349552	43/180 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	69..115		5/45 (11%)
		BACK_KLHL14	181..282	CDD:350528	20/110 (18%)
		Kelch 1	323..372		10/52 (19%)
		NanM	324..577	CDD:442289	67/256 (26%)
		KELCH repeat	363..410	CDD:276965	10/46 (22%)
		Kelch 2	373..424		13/50 (26%)
		KELCH repeat	414..458	CDD:276965	14/43 (33%)
		Kelch 3	425..471		12/45 (27%)
		KELCH repeat	461..506	CDD:276965	13/44 (30%)
		Kelch 4	473..518		15/44 (34%)
		Kelch 5	520..570		14/49 (29%)
		Kelch_1	560..602	CDD:396078	16/43 (37%)
		KELCH repeat	560..602	CDD:276965	16/43 (37%)
		Kelch 6	572..620		11/31 (35%)