Protein Alignment klhl10 and KLHL42

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_065833.1
• Gene: KLHL42 / 57542
• HGNCID: 29252
• Length: 505
• Species: Homo sapiens
• Alignment Length: 355
• Identity: 85/355 - (23%)
• Similarity: 150/355 - (42%)
• Gaps: 60/355 - (16%)

  Fly   328 PQADELTTPPLA--------------MPRLPHEVIFAIGGWSGGT--------SKGCIETYDTRA 370
            ||...|.:||.|              |...|  |:.|:|.:.||.        ....:..|:...
Human   164 PQFHLLGSPPQAPGDVSLKQRLREARMTGTP--VLVALGDFLGGPLAPHPYQGEPPSMLRYEEMT 226

  Fly   371 DRWVTIN---AEDPAGPRAYHGTAVLGFKIFSIGGYD-GVEYFNTCRVFDAVKKKWNEIAPMHCR 431
            :||..:.   ..|....|.| |:|:|...:|.:|||. ..:..:....::....:|.::|.|:.:
Human   227 ERWFPLANNLPPDLVNVRGY-GSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQK 290

  Fly   432 RCYVSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQRSDASACTLQERIYATGG 496
            |....:..:|..:|||||    ..::.||.|||..:.|:.:.|:....::.|||..:.:||..||
Human   291 RSNFKLVAVNSKLYAIGG----QAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGG 351

  Fly   497 FNGQECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGF---NGTARLS------- 551
            :..::...:...|.|.:::||.....:........|:....:|::||.   .|..|.|
Human   352 YTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDML 416

  Fly   552 TGERFDPDTQTWHFIREMNHSRSNFGL--EIIDDMIFAIGGFNGVST-ISHTEC--YVAETDEW- 610
            |.:.::..|:.|.:::| |.|:|...|  .:.:|.|:.:.....:|| :.|...  |...:|.|
Human   417 TVQSYNTVTRQWLYLKE-NTSKSGLNLTCALHNDGIYIMSRDVTLSTSLEHRVFLKYNIFSDSWE 480

  Fly   611 ----MEATDMNIVRSALSANNIAGLPNKRD 636
                ..|...|::.|:|.      ||||.:
Human   481 AFRRFPAFGHNLLVSSLY------LPNKAE 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885
		PHA03098	86..610	CDD:222983	76/322 (24%)
		KELCH repeat	385..428	CDD:276965	11/43 (26%)
		KELCH repeat	432..475	CDD:276965	13/42 (31%)
		KELCH repeat	479..523	CDD:276965	11/43 (26%)
		KELCH repeat	526..571	CDD:276965	11/54 (20%)
		KELCH repeat	573..617	CDD:276965	11/53 (21%)
KLHL42	NP_065833.1	BTB_POZ_KLHL42	4..111	CDD:349628
		BACK_KLHL42_KLHDC5	128..237	CDD:350553	16/74 (22%)
		Kelch 1	176..234		10/59 (17%)
		NanM	235..481	CDD:442289	61/251 (24%)
		Kelch 2	235..282		10/47 (21%)
		KELCH repeat	244..287	CDD:276965	11/43 (26%)
		Kelch 3	284..325		14/44 (32%)
		KELCH repeat	291..331	CDD:276965	14/43 (33%)
		Kelch 4	327..372		10/44 (23%)
		KELCH repeat	334..372	CDD:276965	9/37 (24%)
		Kelch 5	374..429		9/54 (17%)
		Kelch 6	431..480		12/49 (24%)