DRSC/TRiP Functional Genomics Resources

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Protein Alignment klhl10 and klhl2

DIOPT Version :10

Sequence 1:NP_001015100.2 Gene:klhl10 / 3354863 FlyBaseID:FBgn0040038 Length:767 Species:Drosophila melanogaster
Sequence 2:XP_021331972.1 Gene:klhl2 / 567966 ZFINID:ZDB-GENE-090312-193 Length:590 Species:Danio rerio


Alignment Length:584 Identity:179/584 - (30%)
Similarity:294/584 - (50%) Gaps:47/584 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 TILNAHTKSLAPIVSDEALNTLNELREQNLLCDAQISVGEDV-FNVHRAIMCSCSSYFRAQFTGF 114
            ||...|.|        :|...:||||.|::|||..| :.||| ...||.::.:.|.||.|.|||.
Zfish    30 TINPRHMK--------KAFRIMNELRSQSVLCDVTI-IAEDVEIAAHRVVLAAGSPYFHAMFTGE 85

  Fly   115 NADTPGCVDGSDAKKNNNFIHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLV 179
            ..:       |..||    :.|..:....:..:|.|.|..:..::|.||..||..|..:.:..:.
Zfish    86 MTE-------SRQKK----VRIKEIDGWTLGMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQEVK 139

  Fly   180 KKCKDYLGRILTPENCVSIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNIDILDMSAEDFYSII 244
            |.|.::|...|.|.||:.|..||......:|...|..|..::|:||. ::.:.|::..:...|:|
Zfish   140 KACCEFLITQLHPTNCLGIRAFADLHACTELLNLANTYAEQHFSEVV-QSEEFLNLGMDQVCSLI 203

  Fly   245 SDDELNTREEDHVWKLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYVLECEAA 309
            :.|:|....|:.|::..:.|:..:.:.|:.|:||||..|||.|::.:..::.|:|...|....|.
Zfish   204 ASDKLTIPSEEKVFEAVIAWVMHDKDVRQEHLAHLMEHVRLPLLSREYLVQRVEEETLVKNSSAC 268

  Fly   310 KPLIVDTFKFMYDLDFLNPQADELT---------TPPLAMPRLPHEVIFAIGGWSGGTSKGCIET 365
            |..:::..|:     .|.| ||:.:         ..|::.|:    |:..:||.:....:. :|.
Zfish   269 KDYLIEAMKY-----HLLP-ADQRSMMKTIRTRVRTPISYPK----VMMVVGGQAPKAIRS-VEC 322

  Fly   366 YDTRADRWVTINAEDPAGPRAYHGTAVLGFKIFSIGGYDGVEYFNTCRVFDAVKKKWNEIAPMHC 430
            ||...:||..: ||.|: .|...|...:|..::::||::|.....|...:|.||.:|..::.|..
Zfish   323 YDFEEERWFQV-AELPS-RRCRAGVVFMGGVVYAVGGFNGSLRVRTVDAYDPVKDEWCCVSSMQD 385

  Fly   431 RRCYVSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQRSDASACTLQERIYATG 495
            ||..:....|:|::||:||:||...|.|||.||.:.|:|..:.|||.:||......:...:||.|
Zfish   386 RRSTLGCAFLSGLLYAVGGFDGSTGLATVEAYNAKANEWFHVNPMNTRRSSVGVGVVGGLLYAVG 450

  Fly   496 GFNG--QECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFNGTARLSTGERFDP 558
            |::|  ::||.:.|.|:|.||.|:....|..||||......:..||.:||.:|.....:.|.|||
Zfish   451 GYDGATRQCLSTVEAYNPNTNEWSYTAEMGTRRSGAGVGVLKGLLYAVGGHDGPLVRKSCEVFDP 515

  Fly   559 DTQTWHFIREMNHSRSNFGLEIIDDMIFAIGGFNGVSTISHTECYVAETDEW-MEATDMNIVRS 621
            .|.||..:.:||..|.|.|:..:.::::.|||.:|...::..|.|...||:| :..|.|:..||
Zfish   516 ATNTWKQVADMNMCRRNAGVCALSNLLYVIGGDDGSCNLASVEFYNPNTDKWTLLPTCMSTGRS 579

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
klhl10NP_001015100.2 BTB_POZ 62..>108 CDD:453885 17/46 (37%)
PHA03098 86..610 CDD:222983 161/535 (30%)
KELCH repeat 385..428 CDD:276965 11/42 (26%)
KELCH repeat 432..475 CDD:276965 17/42 (40%)
KELCH repeat 479..523 CDD:276965 15/45 (33%)
KELCH repeat 526..571 CDD:276965 16/44 (36%)
KELCH repeat 573..617 CDD:276965 13/44 (30%)
klhl2XP_021331972.1 BTB_POZ 32..152 CDD:453885 41/139 (29%)
PHA03098 53..569 CDD:222983 164/541 (30%)
BACK_KLHL2_Mayven 150..279 CDD:350587 37/134 (28%)
KELCH repeat 340..383 CDD:276965 11/42 (26%)
KELCH repeat 483..527 CDD:276965 15/43 (35%)
KELCH repeat 530..571 CDD:276965 12/40 (30%)

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