DRSC/TRiP Functional Genomics Resources

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Protein Alignment klhl10 and klhl42

DIOPT Version :9

Sequence 1:NP_001015100.2 Gene:klhl10 / 3354863 FlyBaseID:FBgn0040038 Length:767 Species:Drosophila melanogaster
Sequence 2:NP_001038601.2 Gene:klhl42 / 567545 ZFINID:ZDB-GENE-041210-190 Length:472 Species:Danio rerio


Alignment Length:572 Identity:109/572 - (19%)
Similarity:220/572 - (38%) Gaps:137/572 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 QISVGEDVFNVHRAIMCSCSSYFRAQFTGFNADTPGCVDGSDAKKNNNFIHIPGVSSCIMNCVIQ 149
            :|.:.:..:||.::.:...|.||||.::.      |..:.::     :.:.:.|:|:..:..|::
Zfish     9 EIVMDDKTYNVSKSKLIEKSDYFRALYSS------GMRESAE-----DSVRLRGLSAPGLELVLE 62

  Fly   150 YAYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLGRILTPENCVSIMGFARFRFLEDLHLKA 214
            :....:..:....:.:|:..|.::.:..::|    .|...:..||||.:...:....:.:|....
Zfish    63 FINTSKVQVDNETLEDLIETASFLQVTSILK----LLLSEIKQENCVELFKLSEVYGMHELRRAC 123

  Fly   215 RNYTLRYFTEVAYRNIDILDMSAEDFYSIISDDELNTREEDHVWKLCVKWIDRNPESRKRHVAHL 279
            ..:...|:..:..|         .:|..:.:    |.||:..             :.|.:..|.|
Zfish   124 LKFMSCYYHPMLRR---------PEFRMLAA----NVREQIR-------------DIRLKGTATL 162

  Fly   280 MTGVRLGLMTPKCFMEEVKEHPYVLECEAAKPLIVDTFKFMYDLDFLNPQADELTTPPLAMPRLP 344
               |.:|..|..|                              ||..|  .||    |.:|.|  
Zfish   163 ---VAIGDFTHTC------------------------------LDLAN--QDE----PWSMLR-- 186

  Fly   345 HEVIFAIGGWSGGTSKGCIETYDTRADRWVTINA---EDPAGPRAYHGTAVLGFKIFSIGGYDGV 406
                                 |.....||..:.:   :|....|.| |:|||...:|.:|||...
Zfish   187 ---------------------YGEVEQRWKPLASNLPQDMINVRGY-GSAVLDNYLFIVGGYRMT 229

  Fly   407 -EYFNTCRVFDAVKKKWNEIAPMHCRRCYVSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWS 470
             :..:....::..|.:||::|.::.:|....:..::|.:||:||:    .|.|||.|:|..:.|:
Zfish   230 SQEISAAHCYNPSKNEWNQVASLNQKRSNFKLLAVSGKLYAVGGH----CLGTVECYSPEQDWWT 290

  Fly   471 VIPPMNMQRSDASACTLQERIYATGGFNGQECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFR 535
            .:.|:....::.|||..|..||..||:..::...:...|.|.::.|:...:.:........::..
Zfish   291 CVAPLPDPLAEFSACECQGMIYVMGGYTSKDRNTNVLRYCPASDAWSVFHSCSAHVRKQQMLSVE 355

  Fly   536 NQLYVIGGF--------NGTARLS------TGERFDPDTQTWHFIREMNHSRS--NFGLEIIDDM 584
            :.:|::||:        :|..|||      |.:.::..|..|..::| |.|:|  |....:.:|.
Zfish   356 DTIYLVGGYTHELEARESGRRRLSQTEDMLTVQSYNVQTGEWLQLKE-NTSKSGPNLTCTLHNDG 419

  Fly   585 IFAIGGFNGVSTISHTECYVAE---TDEW-----MEATDMNIVRSALSANNI 628
            |:.:.....:.|......::..   :|.|     ..|...|::..:|...|:
Zfish   420 IYIMSRDVSLPTSQEHRVFLKYNIFSDAWEAFRRFPALGQNMLLCSLYLPNV 471

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
klhl10NP_001015100.2 BTB 72..186 CDD:279045 15/100 (15%)
PHA03098 86..610 CDD:222983 104/546 (19%)
BACK 195..298 CDD:285009 16/102 (16%)
Kelch 347..394 CDD:128874 9/49 (18%)
KELCH repeat 385..428 CDD:276965 14/43 (33%)
Kelch 396..442 CDD:128874 9/46 (20%)
Kelch_1 431..476 CDD:279660 14/44 (32%)
KELCH repeat 432..475 CDD:276965 13/42 (31%)
KELCH repeat 479..523 CDD:276965 11/43 (26%)
Kelch 490..536 CDD:128874 7/45 (16%)
Kelch_1 525..570 CDD:279660 11/58 (19%)
KELCH repeat 526..571 CDD:276965 11/58 (19%)
Kelch_1 573..617 CDD:279660 8/53 (15%)
KELCH repeat 573..617 CDD:276965 8/53 (15%)
klhl42NP_001038601.2 PHA03098 2..455 CDD:222983 105/554 (19%)
BTB 10..94 CDD:279045 15/98 (15%)
SPOP_C_like 102..154 CDD:269810 11/77 (14%)
Kelch_1 209..253 CDD:279660 14/44 (32%)
KELCH repeat 209..252 CDD:276965 14/43 (33%)
KELCH repeat 256..296 CDD:276965 14/43 (33%)
Kelch 267..309 CDD:128874 15/45 (33%)
Kelch_1 298..338 CDD:279660 11/39 (28%)
KELCH repeat 299..338 CDD:276965 11/38 (29%)
KELCH repeat 406..449 CDD:276965 6/42 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1072
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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