Protein Alignment klhl10 and klhl42

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_001038601.2
• Gene: klhl42 / 567545
• ZFINID: ZDB-GENE-041210-190
• Length: 472
• Species: Danio rerio
• Alignment Length: 572
• Identity: 109/572 - (19%)
• Similarity: 220/572 - (38%)
• Gaps: 137/572 - (23%)

  Fly    85 QISVGEDVFNVHRAIMCSCSSYFRAQFTGFNADTPGCVDGSDAKKNNNFIHIPGVSSCIMNCVIQ 149
            :|.:.:..:||.::.:...|.||||.::.      |..:.::     :.:.:.|:|:..:..|::
Zfish     9 EIVMDDKTYNVSKSKLIEKSDYFRALYSS------GMRESAE-----DSVRLRGLSAPGLELVLE 62

  Fly   150 YAYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLGRILTPENCVSIMGFARFRFLEDLHLKA 214
            :....:..:....:.:|:..|.::.:..::|    .|...:..||||.:...:....:.:|....
Zfish    63 FINTSKVQVDNETLEDLIETASFLQVTSILK----LLLSEIKQENCVELFKLSEVYGMHELRRAC 123

  Fly   215 RNYTLRYFTEVAYRNIDILDMSAEDFYSIISDDELNTREEDHVWKLCVKWIDRNPESRKRHVAHL 279
            ..:...|:..:..|         .:|..:.:    |.||:..             :.|.:..|.|
Zfish   124 LKFMSCYYHPMLRR---------PEFRMLAA----NVREQIR-------------DIRLKGTATL 162

  Fly   280 MTGVRLGLMTPKCFMEEVKEHPYVLECEAAKPLIVDTFKFMYDLDFLNPQADELTTPPLAMPRLP 344
               |.:|..|..|                              ||..|  .||    |.:|.|
Zfish   163 ---VAIGDFTHTC------------------------------LDLAN--QDE----PWSMLR-- 186

  Fly   345 HEVIFAIGGWSGGTSKGCIETYDTRADRWVTINA---EDPAGPRAYHGTAVLGFKIFSIGGYDGV 406
                                 |.....||..:.:   :|....|.| |:|||...:|.:|||...
Zfish   187 ---------------------YGEVEQRWKPLASNLPQDMINVRGY-GSAVLDNYLFIVGGYRMT 229

  Fly   407 -EYFNTCRVFDAVKKKWNEIAPMHCRRCYVSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWS 470
             :..:....::..|.:||::|.::.:|....:..::|.:||:||:    .|.|||.|:|..:.|:
Zfish   230 SQEISAAHCYNPSKNEWNQVASLNQKRSNFKLLAVSGKLYAVGGH----CLGTVECYSPEQDWWT 290

  Fly   471 VIPPMNMQRSDASACTLQERIYATGGFNGQECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFR 535
            .:.|:....::.|||..|..||..||:..::...:...|.|.::.|:...:.:........::..
Zfish   291 CVAPLPDPLAEFSACECQGMIYVMGGYTSKDRNTNVLRYCPASDAWSVFHSCSAHVRKQQMLSVE 355

  Fly   536 NQLYVIGGF--------NGTARLS------TGERFDPDTQTWHFIREMNHSRS--NFGLEIIDDM 584
            :.:|::||:        :|..|||      |.:.::..|..|..::| |.|:|  |....:.:|.
Zfish   356 DTIYLVGGYTHELEARESGRRRLSQTEDMLTVQSYNVQTGEWLQLKE-NTSKSGPNLTCTLHNDG 419

  Fly   585 IFAIGGFNGVSTISHTECYVAE---TDEW-----MEATDMNIVRSALSANNI 628
            |:.:.....:.|......::..   :|.|     ..|...|::..:|...|:
Zfish   420 IYIMSRDVSLPTSQEHRVFLKYNIFSDAWEAFRRFPALGQNMLLCSLYLPNV 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	5/22 (23%)
		PHA03098	86..610	CDD:222983	104/546 (19%)
		KELCH repeat	385..428	CDD:276965	14/43 (33%)
		KELCH repeat	432..475	CDD:276965	13/42 (31%)
		KELCH repeat	479..523	CDD:276965	11/43 (26%)
		KELCH repeat	526..571	CDD:276965	11/58 (19%)
		KELCH repeat	573..617	CDD:276965	8/53 (15%)
klhl42	NP_001038601.2	PHA03098	2..455	CDD:222983	105/554 (19%)
		BTB_POZ_KLHL42	5..87	CDD:349628	14/88 (16%)
		BACK_KLHL42_KLHDC5	99..202	CDD:350553	29/190 (15%)
		KELCH repeat	209..252	CDD:276965	14/43 (33%)
		KELCH repeat	256..296	CDD:276965	14/43 (33%)
		KELCH repeat	299..338	CDD:276965	11/38 (29%)