Protein Alignment klhl10 and klhl5

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_001164413.1
• Gene: klhl5 / 560697
• ZFINID: ZDB-GENE-080424-7
• Length: 769
• Species: Danio rerio
• Alignment Length: 605
• Identity: 180/605 - (29%)
• Similarity: 298/605 - (49%)
• Gaps: 40/605 - (6%)

  Fly    34 NADGNSPEDKTLGIGRKTILNAHTKSLAPIVSDE-------ALNTLNELR---EQNLLCDAQISV 88
            |.:.:|...:|   ...::..:...|:.|.||||       |.:|...:.   ....|||..:..
Zfish   179 NVESDSSSCRT---SNSSVTLSSCASMEPCVSDEHFQAHSHAEHTFRRMEAYLRTRKLCDVVLLA 240

  Fly    89 GEDVFNVHRAIMCSCSSYFRAQFTGFNADTPGCVDGSDAKKNNNFIHIPGVSSCIMNCVIQYAYL 153
            |:.....||.::.|.|.||.|.||.         |..:||:..  |.:.||....:..::||||.
Zfish   241 GDRRIPAHRLVLSSVSDYFAAMFTS---------DVREAKQEE--IKMEGVDPDALWVLVQYAYT 294

  Fly   154 RQTNISESNVHELLICADYVGMVGLVKKCKDYLGRILTPENCVSIMGFARFRFLEDLHLKARNYT 218
            .:..:.|..:..||..:..:.:..:|:.|..||.:.|.|.||:.|..||..:...|||..|.|||
Zfish   295 GRLELREDTIESLLSGSCLLQLSAVVQACCSYLMKQLHPSNCLGIRSFADAQGCLDLHKVAHNYT 359

  Fly   219 LRYFTEVAYRNIDILDMSAEDFYSIISDDELNTREEDHVWKLCVKWIDRNPESRKRHVAHLMTGV 283
            :.:|.|| .|:.:.|.:.:.:...:::.|::|..||:.|....:.|:..:..:|:..::.|:..:
Zfish   360 MEHFMEV-MRHQEFLLLPSCEVEKLLASDDMNVPEEETVVTALLSWVRHDVTTRQSQLSALLAHI 423

  Fly   284 RLGLMTPKCFMEEVKEHPYVLECEAAKPLIVDTFKFMYDLDFLNPQADELTTPPLAMPR-LPHEV 347
            ||.|:.|: |:.:::.:|.:.:....:.|:::..|:     .|.|:...|...|...|| .....
Zfish   424 RLPLLKPQ-FLADMEANPLLRDSVECQRLVMEAMKY-----HLLPERRPLLQSPRTRPRKATVGA 482

  Fly   348 IFAIGGWSGGTSKGCIETYDTRADRWVTINAEDPAGPRAYHGTAVLGFKIFSIGGYDGVEYFNTC 412
            :||:||.........||.|..|.|.|..:..  .:|.|...|.|||..:::.:||.||::..||.
Zfish   483 LFAVGGMDATKGATSIEQYCLRRDTWRQVAV--MSGRRLQFGVAVLDDRLYVVGGRDGLKTLNTV 545

  Fly   413 RVFDAVKKKWNEIAPMHCRRCYVSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNM 477
            ..::...|.|:.:.||...|..:.|..|.|.:||:||:||.:.|:||||::|:..|||.:..|..
Zfish   546 ECYNPRSKSWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLSTVERWDPQARQWSFVASMAT 610

  Fly   478 QRSDASACTLQERIYATGGFNGQECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIG 542
            .||......|..::||.||.:|..||.|.|.:||.||.|:....|:.||.||....:...||.||
Zfish   611 PRSTVGVAVLNSKLYAVGGRDGSSCLKSVECFDPHTNKWSSCAPMSKRRGGVGVATWNGFLYAIG 675

  Fly   543 GFNGTA-----RLS-TGERFDPDTQTWHFIREMNHSRSNFGLEIIDDMIFAIGGFNGVSTISHTE 601
            |.:..|     ||| ..||:||.|..|..:..|:.||...|:.::.|.::|:||::|...::..|
Zfish   676 GHDAPASSLASRLSDCVERYDPKTDMWTAVAPMSLSRDAVGVCLLGDRLYAVGGYDGQVYLNTVE 740

  Fly   602 CYVAETDEWMEATDMNIVRS 621
            .|..:|:||.:...:.:.|:
Zfish   741 AYDPQTNEWTQVAPLCLGRA 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	16/55 (29%)
		PHA03098	86..610	CDD:222983	163/530 (31%)
		KELCH repeat	385..428	CDD:276965	13/42 (31%)
		KELCH repeat	432..475	CDD:276965	19/42 (45%)
		KELCH repeat	479..523	CDD:276965	17/43 (40%)
		KELCH repeat	526..571	CDD:276965	19/50 (38%)
		KELCH repeat	573..617	CDD:276965	12/43 (28%)
klhl5	NP_001164413.1	PHA03098	225..756	CDD:222983	168/550 (31%)
		KELCH repeat	518..561	CDD:276965	13/42 (31%)
		KELCH repeat	565..609	CDD:276965	19/43 (44%)
		KELCH repeat	612..655	CDD:276965	17/42 (40%)
		KELCH repeat	659..709	CDD:276965	18/49 (37%)
		KELCH repeat	712..755	CDD:276965	12/42 (29%)