DRSC/TRiP Functional Genomics Resources

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Protein Alignment klhl10 and KLHL9

DIOPT Version :10

Sequence 1:NP_001015100.2 Gene:klhl10 / 3354863 FlyBaseID:FBgn0040038 Length:767 Species:Drosophila melanogaster
Sequence 2:NP_061335.1 Gene:KLHL9 / 55958 HGNCID:18732 Length:617 Species:Homo sapiens


Alignment Length:587 Identity:148/587 - (25%)
Similarity:254/587 - (43%) Gaps:101/587 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 NAHTKSLAPIVSDEALNTLNELREQNLLCDAQI--SVGEDVFNVHRAIMCSCSSYFRAQFTGFNA 116
            |.|        |...|...::||.:.||||..:  ..|:::|.||||:|.|.|.||:|.|||   
Human    30 NTH--------SSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTG--- 83

  Fly   117 DTPGCVDGSDAKKNNNF--IHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLV 179
                      ..|..:.  |.:.||:...:..:|.:.|..:.:::..|:.:.|..|.::.::.::
Human    84 ----------GMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVL 138

  Fly   180 KKCKDYLGRILTPENCVSIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNIDILDMSAEDFYSII 244
            ..||.:|...::.:|||.:...|....|.::.....|:.|:.|..:.... :.|.:..|....::
Human   139 DFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTG-EFLKLPFERLAFVL 202

  Fly   245 SDDELNTREEDHVWKLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYVLECEAA 309
            |.:.|....|..::|...:|: |..:.|..:.|.||..:|..||||:..:..|:...::......
Human   203 SSNSLKHCTELELFKAACRWL-RLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTC 266

  Fly   310 KPLIVDTFKFMYDLDFLNP--QADELTTPPLAMPRLPHEVIFAIGG---WSGGTSKGCIETYDTR 369
            ..|:::...:.. :.::.|  |:|....      |.....:..:||   .....||. :..||.|
Human   267 VNLLLEASNYQM-MPYMQPVMQSDRTAI------RSDSTHLVTLGGVLRQQLVVSKE-LRMYDER 323

  Fly   370 ADRWVTINAEDPAGPRAYHGTAVLGFKIFSIGG---YD--GVEYFNTCRVFDAVKKKWNEIAPMH 429
            |..|.::...|  .||..||.||:|..::.:||   ||  |....:|...||....||.::|.::
Human   324 AQEWRSLAPMD--APRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLN 386

  Fly   430 CRRCYVSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMN------------------ 476
            .:|.:..::.|.|.:||:||......|.|||.||||.|:||.:..|:                  
Human   387 EKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYIS 451

  Fly   477 ----------------------MQRSDASA-------CTLQERIYATGG--FNGQECLD---SAE 507
                                  ||::..:.       ||:.:::|..||  |.|....|   |.|
Human   452 GGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCE 516

  Fly   508 YYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGF--NGTARLSTGERFDPDTQTWHFIREMN 570
            ||.|..:.||.|..|...:|.|....|.|::||:||:  |....:...:::||:...||.:.::.
Human   517 YYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLP 581

  Fly   571 HS 572
            .|
Human   582 ES 583

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
klhl10NP_001015100.2 BTB_POZ 62..>108 CDD:453885 18/47 (38%)
PHA03098 86..610 CDD:222983 138/555 (25%)
KELCH repeat 385..428 CDD:276965 17/47 (36%)
KELCH repeat 432..475 CDD:276965 18/42 (43%)
KELCH repeat 479..523 CDD:276965 16/55 (29%)
KELCH repeat 526..571 CDD:276965 13/46 (28%)
KELCH repeat 573..617 CDD:276965 148/587 (25%)
KLHL9NP_061335.1 BTB_POZ_KLHL9_13 27..154 CDD:349548 37/144 (26%)
PHA03098 50..593 CDD:222983 140/559 (25%)
Kelch 1 300..347 16/49 (33%)
KELCH repeat 337..385 CDD:276965 17/47 (36%)
Kelch 2 348..399 13/50 (26%)
KELCH repeat 389..433 CDD:276965 18/43 (42%)
Kelch 3 400..446 16/45 (36%)
KELCH repeat 436..481 CDD:276965 2/44 (5%)
Kelch 4 448..493 4/44 (9%)
KELCH repeat 483..532 CDD:276965 16/48 (33%)
Kelch 5 495..545 18/49 (37%)
KELCH repeat 535..582 CDD:276965 13/46 (28%)
Kelch 6 546..595 10/38 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 595..617
Blue background indicates that the domain is not in the aligned region.

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