DRSC/TRiP Functional Genomics Resources

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Protein Alignment klhl10 and KBTBD4

DIOPT Version :10

Sequence 1:NP_001015100.2 Gene:klhl10 / 3354863 FlyBaseID:FBgn0040038 Length:767 Species:Drosophila melanogaster
Sequence 2:NP_001305645.1 Gene:KBTBD4 / 55709 HGNCID:23761 Length:567 Species:Homo sapiens


Alignment Length:649 Identity:127/649 - (19%)
Similarity:216/649 - (33%) Gaps:206/649 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 ADGNSPEDKTLGIGRKTILN------AHTKSLAPIVSDEALNTLNELREQNLLCDAQISVGEDVF 93
            |...|||:....:.....:|      :|:..:|..:....|       |:.|..|..|||....|
Human    48 ASMESPEEPGASMDENYFVNYTFKDRSHSGRVAQGIMKLCL-------EEELFADVTISVEGREF 105

  Fly    94 NVHRAIMCSCSSYFRAQFTGFNADTPGCVDGSDAKK-NNNFIHIPGVSSCIMNCVIQYAYLRQTN 157
            .:||.::.:.|.:||:.||            |:.|: :|..|.:..||..:...::.|.|.....
Human   106 QLHRLVLSAQSCFFRSMFT------------SNLKEAHNRVIVLQDVSESVFQLLVDYIYHGTVK 158

  Fly   158 ISESNVHELLICADYVGMVGLVKKCKDYLGRILTPENCVSIMGFARFRFLEDLHLKARNYTLRYF 222
            :....:.|:...:|...:..|.::|..:|.|.:...||:.:|..|......:|:..|::....:.
Human   159 LRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLADRHSDPELYTAAKHCAKTHL 223

  Fly   223 TEVAYRNIDILDMSAEDFY--------SIISDD---ELNTREEDHVWKLCVKWIDRNPESRKRHV 276
            .::         .:.|:|.        .||||.   ..|..|....      ||:.|.|.|:...
Human   224 AQL---------QNTEEFLHLPHRLLTDIISDGVPCSQNPTEAIEA------WINFNKEEREAFA 273

  Fly   277 AHLMTGVRLGLMTPKCFMEEVKE--HPYVLECEAAKPLIVDTFKFMYDLDFLNPQADELTTPPLA 339
            ..|.|.           ::|:.|  |.|::..|:::                        |..||
Human   274 ESLRTS-----------LKEIGENVHIYLIGKESSR------------------------THSLA 303

  Fly   340 MPRLPHEVIFAIGGWSGGTSKGCIETYDTRADRWVTINAEDPAGPRAYHGTAVLGFKIFSIGGYD 404
            :                  |..|               |||.:               .|:.|.:
Human   304 V------------------SLHC---------------AEDDS---------------ISVSGQN 320

  Fly   405 GVEYFNTCRVFDAVKKKWNEIAPMHCRRCYVSVTELNGMIYAIGGYDGHNRLNTVER----YNPR 465
            .:     |....|.           |:.        .|.:|.:||        ::.|    .|..
Human   321 SL-----CHQITAA-----------CKH--------GGDLYVVGG--------SIPRRMWKCNNA 353

  Fly   466 TNQWSVIPPMNMQRSDASACTL--QERIYATGGFNGQECLDSAE-YYDPVTNVWTRIPNMNHRRS 527
            |..|....|:...|...:..::  ::.||:.||...|:.|.:|. ||....||||....:....|
Human   354 TVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTETTQLEVAVS 418

  Fly   528 GVSCVAFRNQLYVIGG-------FNGTARLSTGERFDPDTQTWH-------FIREMNHSRSNFGL 578
            |.:.......:|::||       |...:||.  :.||.:|...|       |...|:.:      
Human   419 GAAGANLNGIIYLLGGEENDLDFFTKPSRLI--QCFDTETDKCHVKPYVLPFAGRMHAA------ 475

  Fly   579 EIIDDMIFAIGGFNGVSTISHTECYVAETDEWMEATDMNIVRSALSANNIAGLPNKRDYIHKER 642
             :..|::|.:.  .|.|.:    ||....|.:..........||.|...||.. |...|:.::|
Human   476 -VHKDLVFIVA--EGDSLV----CYNPLLDSFTRLCLPEAWSSAPSLWKIASC-NGSIYVFRDR 531

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
klhl10NP_001015100.2 BTB_POZ 62..>108 CDD:453885 11/45 (24%)
PHA03098 86..610 CDD:222983 108/558 (19%)
KELCH repeat 385..428 CDD:276965 4/42 (10%)
KELCH repeat 432..475 CDD:276965 8/46 (17%)
KELCH repeat 479..523 CDD:276965 14/46 (30%)
KELCH repeat 526..571 CDD:276965 14/58 (24%)
KELCH repeat 573..617 CDD:276965 7/43 (16%)
KBTBD4NP_001305645.1 KELCH repeat 367..414 CDD:276965 14/46 (30%)
KELCH repeat 417..463 CDD:276965 12/47 (26%)
KELCH repeat 471..516 CDD:276965 11/57 (19%)
BTB_POZ_KBTBD4 62..201 CDD:349581 34/157 (22%)
PHA03098 96..528 CDD:222983 115/589 (20%)
BACK_KBTBD4 191..278 CDD:350556 20/101 (20%)
KELCH repeat 328..363 CDD:276965 10/61 (16%)

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