Protein Alignment klhl10 and KLHL26

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_001332910.1
• Gene: KLHL26 / 55295
• HGNCID: 25623
• Length: 644
• Species: Homo sapiens
• Alignment Length: 614
• Identity: 148/614 - (24%)
• Similarity: 253/614 - (41%)
• Gaps: 102/614 - (16%)

  Fly    61 APIVSDEALNTLNELREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRAQFT----GFNADTP-- 119
            ||..|...|..|..||.|..|.|..:::..:.|..|:.::.:||.|||..|.    .:.|.||
Human    42 APSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRLLFPRPDHSWLAKTPLS 106

  Fly   120 ------------GCVDGSDAKKNNNFIHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLICADY 172
                        ....|...:.:.:.|.:.|||:..:..:|.:||..:..:....|.::|..|.:
Human   107 HCQPHVVFLPFRAMFTGGMREASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVF 171

  Fly   173 VGMVGLVKKCKDYLGRILTPENCVSIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNIDILDMSA 237
            :.|:.:|:.|:::|...::.|.|::|...|....|..|......:|.|:|.::|... |.|.:..
Human   172 LQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEE-DFLRLPL 235

  Fly   238 EDFYSIISDDELNTREEDHVWKLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKEHPY 302
            |.....:..:.|.:..|..:::..|:|:..:|..|.| .:|::..:|..||.....::.|:....
Human   236 ERLVFFLQSNRLQSCAEIDLFRAAVRWLQHDPARRPR-ASHVLCHIRFPLMQSSELVDSVQTLDI 299

  Fly   303 VLECEAAKPLIVDTFKFMYDLDFLNPQADELTTPPLAM-PRLPHEVIFAIGGWSGGTSKGCIETY 366
            ::|....:..:::.|.:.. |.|   :..|:.:|..|: ..:|..|.|      |||..
Human   300 MVEDVLCRQYLLEAFNYQV-LPF---RQHEMQSPRTAVRSDVPSLVTF------GGTPY------ 348

  Fly   367 DTRADRWVTINAEDPAGPRAYH--------------GTAVLGFKIFSIGGY-----DGVEYFNTC 412
             |.:||.|:........|.|.|              ..|||...::..||.     .|....:.|
Human   349 -TDSDRSVSSKVYQLPEPGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDAC 412

  Fly   413 RVFDAVKKKWNEIAPMHCRRCYVSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNM 477
            ..:|....:|..:..|...|....:..|.||:||.||.:....|.:||||.||.|:|..
Human   413 YRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGY------ 471

  Fly   478 QRSDASACTLQE------------RIYATGGFN-GQECLDSAEYYDPVTNVWTRIPNMNHRRSGV 529
                  ||:|:.            |:|.:||:. ..|...:...||||.:.|.....|:..|...
Human   472 ------ACSLKRRTWGHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLH 530

  Fly   530 SCVAFRNQLYVIGGFNGTARLSTGER-FD--------PDTQTWHFIREMNHSRSNFGLEIIDDMI 585
            :.|....::|.:||     |:...:| ||        |:|..|..:..|...:|..|..:::..|
Human   531 AMVGAGGRIYALGG-----RMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKI 590

  Fly   586 FAIGGF----NGVSTISHTECYVAETDEW 610
            :.:||:    |.|:.|  .:.|..:||||
Human   591 YIVGGYNWRLNNVTGI--VQVYNTDTDEW 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	14/45 (31%)
		PHA03098	86..610	CDD:222983	136/587 (23%)
		KELCH repeat	385..428	CDD:276965	11/61 (18%)
		KELCH repeat	432..475	CDD:276965	17/42 (40%)
		KELCH repeat	479..523	CDD:276965	13/56 (23%)
		KELCH repeat	526..571	CDD:276965	13/53 (25%)
		KELCH repeat	573..617	CDD:276965	13/42 (31%)
KLHL26	NP_001332910.1	BTB_POZ_KLHL26	45..194	CDD:349564	35/148 (24%)
		BACK_KLHL26	189..285	CDD:350540	22/97 (23%)
		NanM	369..618	CDD:442289	68/268 (25%)
		KELCH repeat	381..428	CDD:276965	9/46 (20%)
		KELCH repeat	432..476	CDD:276965	19/55 (35%)
		KELCH repeat	479..525	CDD:276965	11/45 (24%)
		KELCH repeat	527..574	CDD:276965	12/51 (24%)
		KELCH repeat	578..619	CDD:276965	13/42 (31%)