Protein Alignment klhl10 and Keap1

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_057888.1
• Gene: Keap1 / 50868
• MGIID: 1858732
• Length: 624
• Species: Mus musculus
• Alignment Length: 607
• Identity: 175/607 - (28%)
• Similarity: 283/607 - (46%)
• Gaps: 89/607 - (14%)

  Fly    30 SLQLNADGNSPEDKTLGIGRKTI---LNAHTKSLAPIVSDEALNTLNELREQNLLCDAQISVG-E 90
            |.:..|:....:|     |.:|.   |..|||        :|...:||||....|||..:.|. |
Mouse    35 STECKAEVTPSQD-----GNRTFSYTLEDHTK--------QAFGVMNELRLSQQLCDVTLQVKYE 86

  Fly    91 DV----FNVHRAIMCSCSSYFRAQFT-GFNADTPGCVDGSDAKKNNNFIHIPGVSSCIMNCVIQY 150
            |:    |..|:.::.|.|..|:|.|| |..            ::....:.|.|:...:|..:|::
Mouse    87 DIPAAQFMAHKVVLASSSPVFKAMFTNGLR------------EQGMEVVSIEGIHPKVMERLIEF 139

  Fly   151 AYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLGRILTPENCVSIMGFARFRFLEDLHLKAR 215
            ||....::.|..|..::..|....:..:|:.|.|:|.:.|.|.|.:.|..||......:||.:||
Mouse   140 AYTASISVGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCTELHQRAR 204

  Fly   216 NYTLRYFTEVAYRNIDILDMSAEDFYSIISDDELNTREEDHVWKLCVKWIDRNPESRKRHVAHLM 280
            .|...:|.||| :..:..::|.....::||.|:||.|.|..|:..|:.|:..:...|:.:|..|:
Mouse   205 EYIYMHFGEVA-KQEEFFNLSHCQLATLISRDDLNVRCESEVFHACIDWVKYDCPQRRFYVQALL 268

  Fly   281 TGVRLGLMTPKCFMEEVKEHPYVLECEA-AKPLIVDTFK-------------------------- 318
            ..||...:||: |::...:...:|:.:| .|..:|..|:
Mouse   269 RAVRCHALTPR-FLQTQLQKCEILQADARCKDYLVQIFQELTLHKPTQAVPCRAPKVGRLIYTAG 332

  Fly   319 --FMYDLDFL---NP-QADELTTPPLAMPR------LPHEVIFAIGGWS----GGTSKGCIETYD 367
              |...|.:|   || ....|....|.:||      :...:::|:||.:    |.|....::.|:
Mouse   333 GYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYN 397

  Fly   368 TRADRWVTINAEDPAG----PRAYHGTAVLGFKIFSIGGYDGVEYFNTCRVFDAVKKKWNEIAPM 428
            ...::|      .|..    ||...|..|:...|:::||..|..:.::...::..:.:|:.:|||
Mouse   398 PMTNQW------SPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPM 456

  Fly   429 HCRRCYVSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQRSDASACTLQERIYA 493
            ..||..|.|..||.::||:||:||.||||:.|.|.|..|:|.:|.|||..||.|..|.|...|||
Mouse   457 LTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYA 521

  Fly   494 TGGFNGQECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFNGTARLSTGERFDP 558
            .||::||:.|:|.|.||..|..||.:..|.|.||.:.....:.::||:||::|...|.:.|.:||
Mouse   522 AGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHTFLDSVECYDP 586

  Fly   559 DTQTWHFIREMNHSRSNFGLEI 580
            |:.||..:..|...||..|:.:
Mouse   587 DSDTWSEVTRMTSGRSGVGVAV 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	15/50 (30%)
		PHA03098	86..610	CDD:222983	158/548 (29%)
		KELCH repeat	385..428	CDD:276965	9/42 (21%)
		KELCH repeat	432..475	CDD:276965	21/42 (50%)
		KELCH repeat	479..523	CDD:276965	20/43 (47%)
		KELCH repeat	526..571	CDD:276965	15/44 (34%)
		KELCH repeat	573..617	CDD:276965	3/8 (38%)
Keap1	NP_057888.1	BTB_POZ_KLHL19_KEAP1	56..180	CDD:349557	37/143 (26%)
		PHA03098	95..596	CDD:222983	150/520 (29%)
		Kelch 1	327..372		9/44 (20%)
		KELCH repeat	362..409	CDD:276965	9/52 (17%)
		Kelch 2	373..423		12/55 (22%)
		KELCH repeat	413..456	CDD:276965	9/42 (21%)
		Kelch 3	424..470		13/45 (29%)
		KELCH repeat	460..503	CDD:276965	21/42 (50%)
		Kelch 4	471..517		24/45 (53%)
		KELCH repeat	507..551	CDD:276965	20/43 (47%)
		Kelch 5	519..564		19/44 (43%)
		KELCH repeat	554..597	CDD:276965	14/42 (33%)
		Kelch 6	565..611		16/44 (36%)