Protein Alignment klhl10 and keap1

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_001008024.1
• Gene: keap1 / 493386
• XenbaseID: XB-GENE-957785
• Length: 613
• Species: Xenopus tropicalis
• Alignment Length: 578
• Identity: 175/578 - (30%)
• Similarity: 281/578 - (48%)
• Gaps: 53/578 - (9%)

  Fly    65 SDEALNTLNELREQNLLCDAQISVG----EDVFNVHRAIMCSCSSYFRAQFTGFNADTPGCVDGS 125
            :::|...:||||....|||.::.|.    :|.|..|:.::.|.|..|||.||....:   |  |.
 Frog    29 TNQAFQIMNELRLGQQLCDVKLKVKYNDVQDEFVAHKIVLASSSPVFRAMFTNGLRE---C--GM 88

  Fly   126 DAKKNNNFIHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLGRIL 190
            :.      :.|.||...:|..::::||....::.|..|..::..|....|..:||.|.|:|.:.|
 Frog    89 ET------VTIEGVHPKVMQRLLEFAYTASISVGEKCVIHVMNGAVMYQMDSVVKACCDFLIQQL 147

  Fly   191 TPENCVSIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNIDILDMSAEDFYSIISDDELNTREED 255
            .|.|.:.|..||......:||.|||.|....|.||| :..:..::|:....:::|.||||.|.|.
 Frog   148 DPSNAIGIATFAEQIGCHELHQKAREYIYMQFGEVA-KQEEFFNLSSCQLVNLVSRDELNVRCES 211

  Fly   256 HVWKLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYVLECEAAKPLIVDTFKFM 320
            .|:..|:.|:..:.|:|:.::..|:..||...:||.....:::      .||..|.
 Frog   212 EVFHACINWVKYDCENRRPYIQALLRAVRCHSLTPNFLQLQLQ------RCEILKG--------- 261

  Fly   321 YD---LDFLNPQADELT----TPPL--AMPRLPHEVIFAIGGWSGGTSKGCIETYDTRADRWVTI 376
             |   .|:|:....:||    |.||  .:|.:| :.|:..||:. ..|...:|.|:.....|:|:
 Frog   262 -DSRCQDYLSQIFQDLTLHKPTLPLQGRIPNVP-QFIYVAGGYY-RQSLSFLEAYNPVDGEWLTL 323

  Fly   377 NAEDPAGPRAYHGTAVLGFKIFSIGGYDGVEYFN------TCRVFDAVKKKWNEIAPMHCRRCYV 435
            .:.:.  ||:.....|||...:::||.:.....|      .|  ::.:..:|:..|.|...|..|
 Frog   324 ASLEM--PRSGLAGCVLGGLFYAVGGRNNAPDCNKDSGALDC--YNPMNNQWSPCAAMSVPRNRV 384

  Fly   436 SVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQRSDASACTLQERIYATGGFNGQ 500
            ....::|.|||:||..|....|:||||:|..::|.::.||..:|.......|...:||.|||:|.
 Frog   385 GAGVIDGQIYAVGGSHGCLHHNSVERYDPERDEWHMVSPMKTRRIGVGVAVLNRLLYAVGGFDGT 449

  Fly   501 ECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFNGTARLSTGERFDPDTQTWHF 565
            ..|:|||.|.|.|:.|..|.:||..|||....|....:|.:||::||.:|::.||:|.:...|.|
 Frog   450 NRLNSAECYYPETDEWKDIASMNIVRSGAGACALDTSVYAMGGYDGTDQLNSVERYDVEKDDWTF 514

  Fly   566 IREMNHSRSNFGLEIIDDMIFAIGGFNGVSTISHTECYVAETDEWMEATDMNIVRSAL 623
            :..|.|.||..|:.:....|:.:||::|.:.:...|||...||.|.|.|.|...||.:
 Frog   515 VAPMRHRRSALGVTVHQGKIYVLGGYDGSTFLDGVECYNPATDTWTEVTQMTSGRSGV 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	14/46 (30%)
		PHA03098	86..610	CDD:222983	161/542 (30%)
		KELCH repeat	385..428	CDD:276965	10/48 (21%)
		KELCH repeat	432..475	CDD:276965	16/42 (38%)
		KELCH repeat	479..523	CDD:276965	17/43 (40%)
		KELCH repeat	526..571	CDD:276965	16/44 (36%)
		KELCH repeat	573..617	CDD:276965	15/43 (35%)
keap1	NP_001008024.1	BTB_POZ_KLHL19_KEAP1	25..148	CDD:349557	36/129 (28%)
		PHA03098	43..560	CDD:222983	164/550 (30%)
		BACK_KLHL19_KEAP1	146..236	CDD:350533	29/90 (32%)
		KELCH repeat	330..377	CDD:276965	10/48 (21%)
		KELCH repeat	381..424	CDD:276965	16/42 (38%)
		KELCH repeat	428..471	CDD:276965	17/42 (40%)
		KELCH repeat	475..519	CDD:276965	15/43 (35%)
		KELCH repeat	522..565	CDD:276965	15/42 (36%)