DRSC/TRiP Functional Genomics Resources

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Protein Alignment klhl10 and KBTBD13

DIOPT Version :9

Sequence 1:NP_001015100.2 Gene:klhl10 / 3354863 FlyBaseID:FBgn0040038 Length:767 Species:Drosophila melanogaster
Sequence 2:NP_001094832.1 Gene:KBTBD13 / 390594 HGNCID:37227 Length:458 Species:Homo sapiens


Alignment Length:271 Identity:64/271 - (23%)
Similarity:103/271 - (38%) Gaps:57/271 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   367 DTRADRWVTINAEDPAGPRAYHGTAVLGFKIFSIGGYDG----VEYFNTCRVFDAVKKKWNEIAP 427
            |...|.|.|:.|..........|.|.||.|::.:||..|    |.....|  :|.....|:|...
Human   181 DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFC--YDPDGGTWHEFPS 243

  Fly   428 MHCRRCYVSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQRSD---ASACTLQE 489
            .|..|...::...:|.:|||||......:::||||:|....||.:..:....:.   |.||   .
Human   244 PHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQAC---G 305

  Fly   490 RIYATGGFNGQECL------DSAEYYDPVTNVWTRIPNMNHRRSGVSC-VAFRNQLYVIGGFNGT 547
            |::.        ||      .:...|...|:.|..:..:...:|...| ||.|:.|||:.  ||.
Human   306 RLFV--------CLWRPADTTAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVR--NGP 360

  Fly   548 A-----------RLSTGERFDPDTQTWHFI--REMNHSRSNFGLEIIDDMIFAIGGFNGVSTISH 599
            :           .|:||:        |..:  :.:|...:.|...:..|.::.:   |.:.|:  
Human   361 SDDFLHCAIDCLNLATGQ--------WTALPGQFVNSKGALFTAVVRGDTVYTV---NRMFTL-- 412

  Fly   600 TECYVAETDEW 610
              .|..|...|
Human   413 --LYAIEGGTW 421

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
klhl10NP_001015100.2 BTB 72..186 CDD:279045
PHA03098 86..610 CDD:222983 63/269 (23%)
BACK 195..298 CDD:285009
Kelch 347..394 CDD:128874 7/26 (27%)
KELCH repeat 385..428 CDD:276965 13/46 (28%)
Kelch 396..442 CDD:128874 11/49 (22%)
Kelch_1 431..476 CDD:279660 14/44 (32%)
KELCH repeat 432..475 CDD:276965 14/42 (33%)
KELCH repeat 479..523 CDD:276965 9/52 (17%)
Kelch 490..536 CDD:128874 10/52 (19%)
Kelch_1 525..570 CDD:279660 14/58 (24%)
KELCH repeat 526..571 CDD:276965 14/58 (24%)
Kelch_1 573..617 CDD:279660 7/38 (18%)
KELCH repeat 573..617 CDD:276965 7/38 (18%)
KBTBD13NP_001094832.1 BTB 7..101 CDD:295341
BTB 13..101 CDD:197585
Kelch 1 159..209 8/27 (30%)
Kelch_1 202..244 CDD:279660 13/43 (30%)
KELCH repeat 202..244 CDD:276965 13/43 (30%)
Kelch 2 210..258 11/49 (22%)
Kelch_1 247..292 CDD:279660 14/44 (32%)
KELCH repeat 248..292 CDD:276965 14/43 (33%)
Kelch 3 259..305 15/48 (31%)
KELCH repeat 295..336 CDD:276965 9/51 (18%)
Kelch 4 307..350 9/50 (18%)
KELCH repeat 340..383 CDD:276965 14/52 (27%)
Kelch 5 352..400 11/57 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1072
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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