DRSC/TRiP Functional Genomics Resources

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Protein Alignment klhl10 and CG1812

DIOPT Version :10

Sequence 1:NP_001015100.2 Gene:klhl10 / 3354863 FlyBaseID:FBgn0040038 Length:767 Species:Drosophila melanogaster
Sequence 2:NP_608397.1 Gene:CG1812 / 33049 FlyBaseID:FBgn0031119 Length:616 Species:Drosophila melanogaster


Alignment Length:657 Identity:153/657 - (23%)
Similarity:256/657 - (38%) Gaps:171/657 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 SPEDKTLGIGRKTILNAHTKSLAPIVSDEALNTLNELREQNLLCDAQISVGEDVFNVHRAIMCSC 103
            |||::||                       |..||:||.:..|.|..:.|.|..|..||.::.:.
  Fly    28 SPEEETL-----------------------LRGLNKLRNEEKLTDVTLIVEEHRFKAHRVVLAAS 69

  Fly   104 SSYFRAQFTGFNADTPGCVDGSDAKKNNNFIHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLI 168
            |.||.|.|          .|.:..:...:.|::.|:.:..|..:|.|.|.....::..|:.|:|.
  Fly    70 SDYFCAMF----------ADCAMIESRKDEINLYGIKARAMGSIIDYIYTSMLELNYDNIEEILA 124

  Fly   169 CADYVGMVGLVKKCKDYLGRILTPENCVSIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNIDIL 233
            .|.:|.:..::.:|..:||..:..|||::|.|.|....:.||..:|..|...:|.|.|..: |..
  Fly   125 AATHVQVREVIDRCTIFLGAKIEMENCLAIAGMADIYGIMDLSERAYRYMCAHFEEFATTS-DFK 188

  Fly   234 DMSAEDFYSIISDD-ELNTREEDHVWKLC-------------------VKW-------ID--RN- 268
            :|..:....|:|.: .::..|:|.|..:|                   :||       :|  || 
  Fly   189 EMKVDQLRFILSSNYPIDVAEQDLVRLVCSFAIEQQLNESALGDLLRLIKWQHISYKSVDELRNM 253

  Fly   269 ------------PES-----RKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYVLECEAAKPLIVDT 316
                        |.|     ::.|:.||:.||                                 
  Fly   254 NCSLDKGKQLPLPTSYYNRIKQEHMGHLLNGV--------------------------------- 285

  Fly   317 FKFMYDLDFLNPQADELTTPPLAMPRLPHEV------IFAIGG--WSGGTSKGCIETYDTRADRW 373
                            ::....::|:.|..:      :..|||  |:|.|:  .|..:..:...|
  Fly   286 ----------------VSLKDQSLPQGPTNMRGMELCLLKIGGFEWNGLTN--VIMCFSPKKMNW 332

  Fly   374 VTINAEDPAGPRAYHGTAVLGFKIFSIGG-YDGV--EY---FNTCRVFDAVKKKWNEIAPMHCRR 432
            ..:.| .|...:...|||||..|:|.:|| ||..  ||   |..|  :..::..|..|||:...|
  Fly   333 YELTA-IPHIDQCNFGTAVLNNKLFIVGGAYDVFLKEYIHPFGFC--YCPLRNTWMTIAPIQQDR 394

  Fly   433 CYVSVTELNGM-IYAIGG-YDGHNR-----LNTVERYNPRTNQWSVIPPMNMQRSDASACTLQER 490
            |..|:..:... :||:|| .|..|.     ::.||||:...|.|:.:|.:...||..:...:.::
  Fly   395 CRFSLNAVGTQHLYAVGGILDDDNEEALRMISNVERYDIAKNVWTYMPSLQENRSQHAGVVVGDK 459

  Fly   491 IYATGGFNGQECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFNGTARLSTGER 555
            :|.:||.:....|.|...:|..|.||..:.:|.........||..|::|..||::.:.   |..|
  Fly   460 LYISGGVHLANILASMWVFDTKTEVWQELASMPTPCCDHVLVAVDNRIYACGGWHESL---TEWR 521

  Fly   556 --------FDPDTQTWHFIREMNHSRSNFGLEIIDDMIFAIGGFNGVSTI----SHTECYVAETD 608
                    :|.:|.||....::...:...|:..:...||.:||.:...:|    :.|..|..:|.
  Fly   522 VLVEHIYAYDIETNTWSVETKIPAPKFYTGVTAMGRTIFFVGGLDSTESIDRASAETMAYDLDTK 586

  Fly   609 EWMEATD 615
            ||....|
  Fly   587 EWWHEKD 593

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
klhl10NP_001015100.2 BTB_POZ 62..>108 CDD:453885 14/45 (31%)
PHA03098 86..610 CDD:222983 138/603 (23%)
KELCH repeat 385..428 CDD:276965 18/48 (38%)
KELCH repeat 432..475 CDD:276965 16/49 (33%)
KELCH repeat 479..523 CDD:276965 11/43 (26%)
KELCH repeat 526..571 CDD:276965 12/52 (23%)
KELCH repeat 573..617 CDD:276965 12/47 (26%)
CG1812NP_608397.1 BTB_POZ 33..151 CDD:453885 35/150 (23%)
PHA03098 46..588 CDD:222983 140/609 (23%)
KELCH repeat 344..390 CDD:276965 18/47 (38%)
KELCH repeat 394..444 CDD:276965 16/49 (33%)
KELCH repeat 448..492 CDD:276965 11/43 (26%)
KELCH repeat 495..539 CDD:276965 12/46 (26%)

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