DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klhl10 and klhl11

DIOPT Version :9

Sequence 1:	NP_001015100.2	Gene:	klhl10 / 3354863	FlyBaseID:	FBgn0040038	Length:	767	Species:	Drosophila melanogaster
Sequence 2:	NP_956077.1	Gene:	klhl11 / 327313	ZFINID:	ZDB-GENE-030131-5524	Length:	679	Species:	Danio rerio

Alignment Length:	748	Identity:	151/748 - (20%)
Similarity:	257/748 - (34%)	Gaps:	218/748 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LNADGNSPEDKTLGIGRKTILNAHTKSLAPIVSDEALNTLNELREQNLLCDAQI-------SVGE 90
            |..||.|.|.:.....      .|...|:        ...||.|:..|.||..:       :...
Zfish    24 LMGDGESEEAEEFASA------THCSELS--------RRQNEQRKLGLFCDVTLAFSSAPGAANN 74

  Fly    91 DVFNVHRAIMCSCSSYFRAQFTG-FNADTPGCVD----GSDAKKNNNFIHIPGVSSCIMNCVIQY 150
            ..||.||:::.:.:.||.....| |:......|:    .|:|          |:....:..|||:
Zfish    75 FEFNAHRSVLAAATDYFTPLLGGQFSESVTRRVEMKEWSSEA----------GLDQETVESVIQF 129

  Fly   151 AYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLGRILTPENCVSIMGFARFRFLEDLHLKAR 215
            .|..:..:|.:||||:|..||...:|.|...|.::|.|.|:..|||:|...|....|:.|.|:|.
Zfish   130 MYTGEIRVSTANVHEVLELADRFLLVQLKDFCGEFLKRKLSLGNCVAIHSLAHMYTLDQLALRAV 194

  Fly   216 NYTLRYFTEVAYRNIDILDMSAEDFYSI--------ISDDELNTREEDHVWKLCVKWIDRNPESR 272
            :...|.|.:|         :..|:||::        :||.|:....|:.::...|||:.:|.|.|
Zfish   195 DMIRRNFHKV---------IQDEEFYTLPFRLVRDWLSDAEITVDSEEVLFDAVVKWVQKNSEER 250

  Fly   273 KRHVAHLMTGVRLGLMTPKCFMEEVKEHPYVLECEAAKPLIVDTFKFMYDLDFLN-PQAD-ELTT 335
            .::...|...:||..:.|......||..|.|.:..|...|:.:..: .:.:.|.| ..|| |...
Zfish   251 VKYFEELFRLLRLPQIKPTYLTRVVKNEPLVAQNAACLQLVSEAVE-GHAIRFENLKSADTEFWA 314

  Fly   336 PPLA--MPRLPH--EVIFAIGGWSGGTSKGCIETYDTRADRWVTINAEDPAGPRAYHGTAVLGFK 396
            ..:|  .||...  :||..:||.|
Zfish   315 SYMATFQPRFGQNMDVIMVVGGVS----------------------------------------- 338

  Fly   397 IFSIGGYDGVEYFNTCRVFDAVKKKWNEIAPMHCRRCYVSVTELNGMIYAIGGYDGH-------- 453
                   :|.:|.:.|..:...:.:|..:..:|        ..|:|  :||...|.|
Zfish   339 -------EGGDYLSECVGYFVYEDRWVNLPHIH--------NHLDG--HAIAATDTHVYVAGSME 386

  Fly   454 -NRLNTVERYNPRTNQWSVIPPMNMQRSDASACTLQERIYATGGF-NGQECLDSAEYYDPVTNVW 516
             ....|||||||..|.|..:..:..::.......::..:|:.||. |..........|:|..:.|
Zfish   387 PGFAKTVERYNPNRNTWEQVSNLTTRKHSFGLTCIKNILYSIGGHGNFSPGFKDVSVYEPDQDKW 451

  Fly   517 TRIPNMNHRRSGVSCVAFRNQ-LYVIGGFNGTARL-----------STGERFDPDTQTWHFIREM 569
            ..:.:.......|..::..:: :||      |||.           :...|:|.|::.|..:..:
Zfish   452 HNLESAPKILRDVKAISVEDRYVYV------TARTPVDTDSDDGLKTVTTRYDTDSRQWQEVDSL 510

  Fly   570 ----NH------------------------------SRSNFGLEIIDDM---------------- 584
                |:                              :|......|.||:
Zfish   511 PLIDNYCLFQMAVASTNFYHTASCCPKSYTNVRDDVARQKISARISDDILESLPPEVTSIEGAAI 575

  Fly   585 ------IFAIGGFNGVSTI-----SHTECYVAETDEWMEATDMNIVRSALSANNIAGLPNKRDY- 637
                  :|.|||:.....:     .....|.||...||....|...|...:|.::. :|.:..|
Zfish   576 CYLGDDVFVIGGWKNSDDVDKQYRKEAYRYCAERKRWMLLPPMPQPRCRATACHVR-IPYRFLYG 639

  Fly   638 ---------IHKERDRLMEERRQRLMATAMARE 661
                     :.::|||:.:.::.......:.|:
Zfish   640 CQRYPMPQNLARQRDRMQQMQQLHRRTLTLRRQ 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB	72..186	CDD:279045	33/125 (26%)
		PHA03098	86..610	CDD:222983	127/632 (20%)
		BACK	195..298	CDD:285009	28/110 (25%)
		Kelch	347..394	CDD:128874	5/46 (11%)
		KELCH repeat	385..428	CDD:276965	4/42 (10%)
		Kelch	396..442	CDD:128874	6/45 (13%)
		Kelch_1	431..476	CDD:279660	15/53 (28%)
		KELCH repeat	432..475	CDD:276965	15/51 (29%)
		KELCH repeat	479..523	CDD:276965	7/44 (16%)
		Kelch	490..536	CDD:128874	8/46 (17%)
		Kelch_1	525..570	CDD:279660	10/60 (17%)
		KELCH repeat	526..571	CDD:276965	10/60 (17%)
		Kelch_1	573..617	CDD:279660	13/70 (19%)
		KELCH repeat	573..617	CDD:276965	13/70 (19%)
klhl11	NP_956077.1	BTB	50..166	CDD:279045	33/125 (26%)
		PHA03098	54..541	CDD:222983	119/570 (21%)
		BACK	174..276	CDD:285009	28/110 (25%)
		Kelch_1	369..410	CDD:279660	14/42 (33%)
		KELCH repeat	369..409	CDD:276965	14/41 (34%)
		Kelch_1	412..456	CDD:279660	7/43 (16%)
		KELCH repeat	413..458	CDD:276965	7/44 (16%)
		KELCH repeat	461..511	CDD:276965	10/55 (18%)
		KELCH repeat	572..618	CDD:276965	9/45 (20%)
		Kelch	582..628	CDD:128874	11/45 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1072
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900