Protein Alignment klhl10 and keap1a

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_878284.2
• Gene: keap1a / 321837
• ZFINID: ZDB-GENE-030131-556
• Length: 601
• Species: Danio rerio
• Alignment Length: 609
• Identity: 174/609 - (28%)
• Similarity: 284/609 - (46%)
• Gaps: 81/609 - (13%)

  Fly    67 EALNTLNELREQNLLCDAQISVG-EDV---FNVHRAIMCSCSSYFRAQFTGFNADTPGCVDGSDA 127
            :||..::|||...:|||..:.|. :|.   |.||:.::.:.|.||:|.||
Zfish    39 KALQNMDELRHHEMLCDLVLHVTYKDKIVDFKVHKLVLAASSPYFKAMFT--------------- 88

  Fly   128 KKNNNF-------IHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLVKKCKDY 185
               :||       :.:..|...:::.:|.:||..:..:.|:.|..:|:.|....|..:.|.|.|:
Zfish    89 ---SNFKECHASEVTLRDVCPQVISRLIDFAYTSRITVGETCVLHVLLTAMRYQMEEVAKACCDF 150

  Fly   186 LGRILTPENCVSIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNIDILDMSAEDFYS-------- 242
            |.:.|.|.|.:.|..||......||||:.|.|...:|.||.         ..|:|:|
Zfish   151 LMKNLEPSNVIGISRFAEEIGCTDLHLRTREYINTHFNEVT---------KEEEFFSLSHCQLLE 206

  Fly   243 IISDDELNTREEDHVWKLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYVLECE 307
            :||.|.|....|..|:|.|:.|:..:.|||.::...|:..|.:..:.|.....:::..|.:.:..
Zfish   207 LISQDSLKVLCESEVYKACIDWVRWDAESRAQYFHALLNAVHIYALPPTFLKRQLQSCPILSKAN 271

  Fly   308 AAKPLIVDTFKFMYDLDFLNPQADELT-TPPLAMPRLPH---EVIFAIGGWSGGTSKGCIETYDT 368
            :.|             |||:....|:. ..||  |..||   ::|:..||:. ..|...:|.:|.
Zfish   272 SCK-------------DFLSKIFHEMALRKPL--PPTPHRGTQLIYIAGGYK-QHSLDTLEAFDP 320

  Fly   369 RADRWVTINAEDPAGPRAYHGTAVLGFKIFSIGGYDGVEYFNT------CRVFDAVKKKWNEIAP 427
            ..:.|:.:.:  ...|.:..|..||...::::||.:.....||      |  ::.:..:|.::||
Zfish   321 HKNVWLKLGS--MMSPCSGLGACVLFGLLYTVGGRNLSLQNNTESGSLSC--YNPMTNQWTQLAP 381

  Fly   428 MHCRRCYVSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQRSDASACTLQERIY 492
            ::..|..|.|..::|.|||:||.......|:||||:|.||:|:.:.||::.|..|........:|
Zfish   382 LNTPRNRVGVGVIDGSIYAVGGSHASTHHNSVERYDPETNRWTFVAPMSVARLGAGVAACGGCLY 446

  Fly   493 ATGGFNGQECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFNGTARLSTGERFD 557
            ..|||:|....::.|.|.|.||.|..:..||..|||:..|...|.||.:||::|..:|.|.||::
Zfish   447 VVGGFDGDNRWNTVERYQPDTNTWQHVAPMNTVRSGLGVVCMDNYLYAVGGYDGQTQLKTMERYN 511

  Fly   558 PDTQTWHFIREMNHSRSNFGLEIIDDMIFAIGGFNGVSTISHTECYVAETDEWMEATDMNIVRS- 621
            .....|..:..|||.||..|:.:....||.:||||....:|..|||...::.|...|||.:.||
Zfish   512 ITRDVWEPMASMNHCRSAHGVSVYQCKIFVLGGFNQGGFLSSVECYCPASNVWTLVTDMPVGRSG 576

  Fly   622 ---ALSANNIAG-LPNKRDYIHKE 641
               |::.....| ||.:.:.:.:|
Zfish   577 MGVAVTMEPCPGILPEEEEEVDEE 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	15/44 (34%)
		PHA03098	86..610	CDD:222983	155/552 (28%)
		KELCH repeat	385..428	CDD:276965	10/48 (21%)
		KELCH repeat	432..475	CDD:276965	18/42 (43%)
		KELCH repeat	479..523	CDD:276965	13/43 (30%)
		KELCH repeat	526..571	CDD:276965	16/44 (36%)
		KELCH repeat	573..617	CDD:276965	16/43 (37%)
keap1a	NP_878284.2	BTB_POZ_KLHL19_KEAP1	33..156	CDD:349557	34/134 (25%)
		PHA03098	54..571	CDD:222983	160/563 (28%)
		Kelch 1. /evidence=ECO:0000255	292..337		10/47 (21%)
		KELCH repeat	336..382	CDD:276965	10/47 (21%)
		Kelch 2. /evidence=ECO:0000255	338..388		12/51 (24%)
		KELCH repeat	386..429	CDD:276965	18/42 (43%)
		Kelch 3. /evidence=ECO:0000255	389..435		20/45 (44%)
		KELCH repeat	433..477	CDD:276965	13/43 (30%)
		Kelch 4. /evidence=ECO:0000255	436..482		15/45 (33%)
		KELCH repeat	480..525	CDD:276965	16/44 (36%)
		Kelch 5. /evidence=ECO:0000255	484..529		16/44 (36%)
		KELCH repeat	527..572	CDD:276965	17/44 (39%)
		Kelch 6. /evidence=ECO:0000255	530..576		16/45 (36%)