DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klhl10 and KLHL10

DIOPT Version :9

Sequence 1:	NP_001015100.2	Gene:	klhl10 / 3354863	FlyBaseID:	FBgn0040038	Length:	767	Species:	Drosophila melanogaster
Sequence 2:	NP_001316524.1	Gene:	KLHL10 / 317719	HGNCID:	18829	Length:	608	Species:	Homo sapiens

Alignment Length:	618	Identity:	272/618 - (44%)
Similarity:	378/618 - (61%)	Gaps:	25/618 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 HTKSLAPIVSDEALNTLNELREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRAQFT-GFNADTP 119
            |...:...:|..|....||||.:..|||..|.|....|:.|:.|:|||||||||.|| |:|
Human    13 HQPHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWN---- 73

  Fly   120 GCVDGSDAKKNNNFIHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLVKKCKD 184
                 :..||..|   |||:|..:|..:|:|||.|...|:..||.:||..||...::|:|:.|.:
Human    74 -----NTEKKVYN---IPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCE 130

  Fly   185 YLGRILTPENCVSIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNIDILDMSAEDFYSIISDDEL 249
            :|...|..:||:.|..|..:.:..:|..||..:.|..|.|:...:.:.|::|..:...||..|||
Human   131 FLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDEL 195

  Fly   250 NTREEDHVWKLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYVLECEAAKPLIV 314
            |.::||.|::..:|||..:|::||:|::.|:..|||.||..:.||..||.:.||.:.|..||:|:
Human   196 NVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVII 260

  Fly   315 DTFKFMYDLDFLNPQADELTTPPLAMPRLPHEVIFAIGGWSGGTSKGCIETYDTRADRWVTINAE 379
            :..|.||||:...|...:.|. ||..||||:.::|||||||||:....||.||.||||||.:..|
Human   261 NALKAMYDLNMNGPSNSDFTN-PLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCE 324

  Fly   380 DPAGPRAYHGTAVLGFKIFSIGGYDGVEYFNTCRVFDAVKKKWNEIAPMHCRRCYVSVTELNGMI 444
            :.: ||||||.|.|...::.|||:|.|:|||:.:.||.|||.|:::||||.||||||||.|...|
Human   325 EES-PRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFI 388

  Fly   445 YAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQRSDASACTLQERIYATGGFNGQECLDSAEYY 509
            ||:||:||:.||||.|||.|.||||::|.||:.|||||||.||..::|..|||||.|||.:||.|
Human   389 YAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVY 453

  Fly   510 DPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFNGTARLSTGERFDPDTQTWHFIREMNHSRS 574
            :..:|.||.|..|..||||:..:|:...:|.:|||:|..||.:.|.:.|...||..|..|.:.||
Human   454 NTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRS 518

  Fly   575 NFGLEIIDDMIFAIGGFNGVSTISHTECYVAETDEWMEATDMNIVRSALSANNIAGLPNKRDYIH 639
            |||:|::||::|.:|||||.:|..:.|||..:||||.:|.||:|.|||||...:.||.|..:|
Human   519 NFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGLANVEEY-- 581

  Fly   640 KERDRLMEERRQRLMATAMARENVGHGNASQML 672
                   ..||......|: |:.|.:..::..|
Human   582 -------AARRDNFPGLAL-RDEVKYSASTSTL 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB	72..186	CDD:279045	48/114 (42%)
		PHA03098	86..610	CDD:222983	241/524 (46%)
		BACK	195..298	CDD:285009	35/102 (34%)
		Kelch	347..394	CDD:128874	27/46 (59%)
		KELCH repeat	385..428	CDD:276965	22/42 (52%)
		Kelch	396..442	CDD:128874	27/45 (60%)
		Kelch_1	431..476	CDD:279660	30/44 (68%)
		KELCH repeat	432..475	CDD:276965	28/42 (67%)
		KELCH repeat	479..523	CDD:276965	24/43 (56%)
		Kelch	490..536	CDD:128874	22/45 (49%)
		Kelch_1	525..570	CDD:279660	17/44 (39%)
		KELCH repeat	526..571	CDD:276965	17/44 (39%)
		Kelch_1	573..617	CDD:279660	24/43 (56%)
		KELCH repeat	573..617	CDD:276965	24/43 (56%)
KLHL10	NP_001316524.1	BTB	29..133	CDD:279045	48/115 (42%)
		PHA03098	36..572	CDD:222983	255/549 (46%)
		BACK	141..242	CDD:197943	35/100 (35%)
		Kelch 1	292..339		28/47 (60%)
		Kelch	293..339	CDD:128874	28/46 (61%)
		KELCH repeat	329..372	CDD:276965	22/42 (52%)
		Kelch 2	340..386		27/45 (60%)
		Kelch	341..386	CDD:128874	27/44 (61%)
		Kelch_1	375..419	CDD:279660	29/43 (67%)
		KELCH repeat	376..420	CDD:276965	29/43 (67%)
		Kelch 3	388..433		31/44 (70%)
		KELCH repeat	423..466	CDD:276965	24/42 (57%)
		Kelch	434..480	CDD:128874	22/45 (49%)
		Kelch 4	434..480		22/45 (49%)
		KELCH repeat	470..513	CDD:276965	16/42 (38%)
		Kelch	481..527	CDD:128874	19/45 (42%)
		Kelch 5	481..527		19/45 (42%)
		KELCH repeat	517..561	CDD:276965	24/43 (56%)
		Kelch	528..574	CDD:128874	23/45 (51%)
		Kelch 6	529..574		23/44 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154216
Domainoid	1	1.000	84	1.000	Domainoid score	I8317
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12018
Inparanoid	1	1.050	528	1.000	Inparanoid score	I1231
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45628
OrthoDB	1	1.010	-	-		D145100at33208
OrthoFinder	1	1.000	-	-		FOG0005514
OrthoInspector	1	1.000	-	-		oto91823
orthoMCL	1	0.900	-	-		OOG6_105990
Panther	1	1.100	-	-	LDO	PTHR24412
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5079
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800