DRSC/TRiP Functional Genomics Resources

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Protein Alignment klhl10 and Klhdc8a

DIOPT Version :9

Sequence 1:NP_001015100.2 Gene:klhl10 / 3354863 FlyBaseID:FBgn0040038 Length:767 Species:Drosophila melanogaster
Sequence 2:NP_001094153.1 Gene:Klhdc8a / 305096 RGDID:1305132 Length:350 Species:Rattus norvegicus


Alignment Length:305 Identity:81/305 - (26%)
Similarity:130/305 - (42%) Gaps:43/305 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   348 IFAIGGW-SGGTSKGCIETYDTRADRWVTINAEDPAGPRAYHGTAV--LGFKIFSIGGYDG---- 405
            ::||||. ..|....|.|.|...||:|.::    |:.|.|..|.|:  ||.:|..|||...    
  Rat    33 VYAIGGCDDNGVPMDCFEVYSPEADQWTSL----PSLPTARAGVAITALGKRIMVIGGVGTNQLP 93

  Fly   406 ---VEYFNTCRVFDAVKKKWNEIAPMHCRRCYVSVTELNGMIYAIGGYD----GHNRLNTVERYN 463
               ||.:|    .|  :.||.:.:.:......:|||..:..:||.||..    .||.|   :.|:
  Rat    94 VKVVEMYN----ID--EGKWKKRSVLREAAMGISVTAKDYRVYAAGGMGLDLRPHNYL---QHYD 149

  Fly   464 PRTNQWSVIPPMNMQRSDASACTLQERIYATGGFNGQECLDSAEYYDPVTNVWTRIPNMNHRRSG 528
            ...:.|..:.||...|..|::.....:||..||...:..:::.|.:|..:..||:.||:..:|:.
  Rat   150 MLKDMWVSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIESRSWTKFPNIPCKRAF 214

  Fly   529 VSCVAFRNQLYVIGG------FNGTARLSTGERFDPDTQTW------HFIREMNHSRSNFGLEII 581
            .|.|...|.||.:||      :.....|.|.:.||.:...|      .|:::   .|::|....:
  Rat   215 SSFVTLDNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGGWLKMERSFFLKK---RRADFVAGGL 276

  Fly   582 DDMIFAIGGFNGVSTISHT-ECYVAETDEWMEATDMNIVRSALSA 625
            ...:...||.....|:..| |.:..|.::|.....|...|.|.|:
  Rat   277 SGRVIVAGGLGNQPTVLETAEAFHPEKNKWEALPPMPTPRCACSS 321

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
klhl10NP_001015100.2 BTB 72..186 CDD:279045
PHA03098 86..610 CDD:222983 76/288 (26%)
BACK 195..298 CDD:285009
Kelch 347..394 CDD:128874 16/48 (33%)
KELCH repeat 385..428 CDD:276965 15/51 (29%)
Kelch 396..442 CDD:128874 13/52 (25%)
Kelch_1 431..476 CDD:279660 13/48 (27%)
KELCH repeat 432..475 CDD:276965 12/46 (26%)
KELCH repeat 479..523 CDD:276965 12/43 (28%)
Kelch 490..536 CDD:128874 13/45 (29%)
Kelch_1 525..570 CDD:279660 14/56 (25%)
KELCH repeat 526..571 CDD:276965 14/56 (25%)
Kelch_1 573..617 CDD:279660 9/44 (20%)
KELCH repeat 573..617 CDD:276965 9/44 (20%)
Klhdc8aNP_001094153.1 PHA03098 <5..209 CDD:222983 54/188 (29%)
KELCH repeat 21..65 CDD:276965 12/35 (34%)
KELCH repeat 69..162 CDD:276965 27/101 (27%)
PHA03098 <129..333 CDD:222983 50/199 (25%)
KELCH repeat 165..209 CDD:276965 12/43 (28%)
KELCH repeat 212..265 CDD:276965 14/52 (27%)
KELCH repeat 268..314 CDD:276965 10/45 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1072
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.900

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