DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klhl10 and Klhdc7a

DIOPT Version :9

Sequence 1:	NP_001015100.2	Gene:	klhl10 / 3354863	FlyBaseID:	FBgn0040038	Length:	767	Species:	Drosophila melanogaster
Sequence 2:	XP_006239358.1	Gene:	Klhdc7a / 298590	RGDID:	1309439	Length:	773	Species:	Rattus norvegicus

Alignment Length:	669	Identity:	126/669 - (18%)
Similarity:	200/669 - (29%)	Gaps:	247/669 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ESNLLDINEDLPFALALPPVSMDSLQLNADGNSPEDKTLGIGRKTILNAHTKSLAPIVSDEALNT 71
            ||....::..:|.|.||...:      .:.|..||....|        |.|:..|   .:.|..|
  Rat   292 ESTSKAVSRPVPCAAALADAA------PSPGPGPEPLVTG--------AATRDQA---DNTAGGT 339

  Fly    72 LNELREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRAQFTGFNADTPGCVD-----GSDAK--- 128
            |.....|.:...:....|..|    ..:..:.:...:.|..||....|..:|     |||..
  Rat   340 LQVASPQPVPSPSAPGFGRKV----SLLQIAENPELQLQPEGFRMPLPAHLDQSAQLGSDCSHGE 400

  Fly   129 ------KNNNFIHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLG 187
                  ...||.|||          :..|......:...|.:|:|..|...|:..|.:
  Rat   401 PHVQLVAGTNFFHIP----------LTPASALDVRLDLGNCYEMLTLAKRQGLEALKE------- 448

  Fly   188 RILTPENCVSIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNIDILDMSAEDFYSIISDDE---- 248
                          |.::.|.|.:|:.                    :.:.|.|..:|..|
  Rat   449 --------------AAYKVLSDNYLQV--------------------LRSTDIYGGLSGAERELI 479

  Fly   249 LNTREEDHVWKLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKE--HPYVLECEAAKP 311
            |..|...|   .|:...|..|:.....:               |..:.|::  ||
  Rat   480 LQRRFRGH---KCLVVADMCPQEDSGRL---------------CCYDNVQDAWHP---------- 516

  Fly   312 LIVDTFKFMYDLDFLNPQADELTTPPLAMPRLPHEVIFAIGGWSGGTSKGC----IETYDTRADR 372
                                        :.:||.|.:          |:||    :..|     .
  Rat   517 ----------------------------LAQLPLEAM----------SRGCALCSLFNY-----L 538

  Fly   373 WVTINAEDPAGPRAYHGTAVLGFKIFSIGGYDGVEYFNTCRVFDAVKKKWNEIAPMHCRRCYVSV 437
            :|....:.|||..:                       |....::.:...|:|:.|::..|.:..:
  Rat   539 FVVSGCQGPAGQPS-----------------------NRVFCYNPLTAIWSEVCPLNQARPHCRL 580

  Fly   438 TELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQ----RSDASACTLQERIYATGG-- 496
            ..|.|.:|||||    ..|||||||:||.::|:..||:...    ...|:.|.  ..|:.|||
  Rat   581 VALEGYLYAIGG----ECLNTVERYDPRLDRWTFAPPLPNDTFALAHTATVCA--NEIFVTGGSL 639

  Fly   497 ------FNGQECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFNGTARLSTGER 555
                  |:.||            ..|...|....:......||....||.. ..|.:..:|. .|
  Rat   640 RYLLLRFSAQE------------QRWWAGPTAGSKDRTAEMVAVNGFLYRF-DLNRSLGISV-YR 690

  Fly   556 FDPDTQTWHFIREMNHSR----SNFGLEIIDDMIFAIGGFNGVSTISHTECYVAETDEWMEATDM 616
            .:..|:.|:   |....|    ..|...::||.|:.:|.       ..|.|::|:.
  Rat   691 CNASTRLWY---ECATYRLPYPDAFQCAVVDDRIYCVGR-------RRTLCFLADH--------- 736

  Fly   617 NIVRSALSANNIAGLPNKR 635
              :......|.:.|.|..|
  Rat   737 --ISPRFVPNELQGFPAAR 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB	72..186	CDD:279045	24/127 (19%)
		PHA03098	86..610	CDD:222983	105/563 (19%)
		BACK	195..298	CDD:285009	15/106 (14%)
		Kelch	347..394	CDD:128874	8/50 (16%)
		KELCH repeat	385..428	CDD:276965	3/42 (7%)
		Kelch	396..442	CDD:128874	6/45 (13%)
		Kelch_1	431..476	CDD:279660	20/44 (45%)
		KELCH repeat	432..475	CDD:276965	19/42 (45%)
		KELCH repeat	479..523	CDD:276965	11/51 (22%)
		Kelch	490..536	CDD:128874	11/53 (21%)
		Kelch_1	525..570	CDD:279660	10/44 (23%)
		KELCH repeat	526..571	CDD:276965	10/44 (23%)
		Kelch_1	573..617	CDD:279660	9/47 (19%)
		KELCH repeat	573..617	CDD:276965	9/47 (19%)
Klhdc7a	XP_006239358.1	Kelch_1	525..568	CDD:279660	10/80 (13%)
		KELCH repeat	527..571	CDD:276965	10/71 (14%)
		Kelch_1	574..615	CDD:279660	20/44 (45%)
		KELCH repeat	575..615	CDD:276965	20/43 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1072
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900