Protein Alignment klhl10 and Klhl2

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_001406494.1
• Gene: Klhl2 / 290692
• RGDID: 1306388
• Length: 593
• Species: Rattus norvegicus
• Alignment Length: 629
• Identity: 188/629 - (29%)
• Similarity: 304/629 - (48%)
• Gaps: 68/629 - (10%)

  Fly    23 LPPV--------SMDSLQLNADGNSPEDKTLGIGRKTILNAHTKSLAPIVSDEALNTLNELREQN 79
            |||.        .:||...|.:.:.|         .|:...|.|        :|...:||||.||
  Rat     6 LPPACTKQGHQKPLDSKDENPEKHCP---------LTVNPWHMK--------KAFKVMNELRSQN 53

  Fly    80 LLCDAQISVGEDV-FNVHRAIMCSCSSYFRAQFTGFNADTPGCVDGSDAKKNNNFIHIPGVSSCI 143
            ||||..| |.||: ...||.::.:||.||.|.|||..::       |.||:    :.|..|....
  Rat    54 LLCDVTI-VAEDMEIPAHRVVLAACSPYFHAMFTGEMSE-------SRAKR----VRIKEVDGWT 106

  Fly   144 MNCVIQYAYLRQTNISESNVHELLICADYVGMVGLVKKCKDYLGRILTPENCVSIMGFARFRFLE 208
            :..:|.|.|..:..::|.||..||..|..:.:..:.|.|.::|...|.|.||:.|..||......
  Rat   107 LRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACT 171

  Fly   209 DLHLKARNYTLRYFTEVAYRNIDILDMSAEDFYSIISDDELNTREEDHVWKLCVKWIDRNPESRK 273
            ||..||..|..::|.:|.... :.|::..|...|:||.|:|....|:.|::..:.|::.:.:.|:
  Rat   172 DLLNKANTYAEQHFADVVLSE-EFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQ 235

  Fly   274 RHVAHLMTGVRLGLMTPKCFMEEVKEHPYVLECEAAKPLIVDTFKFMYDLDFLNPQADEL----- 333
            ..:|.||..|||.|:..:..::.|:|...|....|.|..:::..|:     .|.|....:
  Rat   236 EFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKY-----HLLPTEQRMLMKSV 295

  Fly   334 ---TTPPLAMPRLPHEVIFAIGGWSGGTSKGCIETYDTRADRWVTINAEDPAGPRAYHGTAVLGF 395
               ...|:.:|:|    :..:||.:....:. :|.||.:.:||..: ||.|: .|...|...:..
  Rat   296 RTRLRTPMNLPKL----MVVVGGQAPKAIRS-VECYDFKEERWHQV-AELPS-RRCRAGMVYMAG 353

  Fly   396 KIFSIGGYDGVEYFNTCRVFDAVKKKWNEIAPMHCRRCYVSVTELNGMIYAIGGYDGHNRLNTVE 460
            .:|::||::|.....|...:|.||.:|..:|.|..||..:....|||::||:||:||...|::||
  Rat   354 LVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVE 418

  Fly   461 RYNPRTNQWSVIPPMNMQRSDASACTLQERIYATGGFNG--QECLDSAEYYDPVTNVWTRIPNMN 523
            .||.::|:|..:.|||.:||......:...:||.||::|  ::||.:.|.|:...|.||.|..|:
  Rat   419 AYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATANEWTYIAEMS 483

  Fly   524 HRRSGVSCVAFRNQLYVIGGFNGTARLSTGERFDPDTQTWHFIREMNHSRSNFGLEIIDDMIFAI 588
            .||||.......|.||.:||.:|.....:.|.:||.|..|..:.:||..|.|.|:..::.:::.:
  Rat   484 TRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVV 548

  Fly   589 GGFNGVSTISHTECYVAETDEWMEATDMNIVRSALS-ANNIAGL 631
            ||.:|...::..|.|...||:|      .:|.|.:| ..:.||:
  Rat   549 GGDDGSCNLASVEYYNPTTDKW------TVVSSCMSTGRSYAGV 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	20/46 (43%)
		PHA03098	86..610	CDD:222983	161/534 (30%)
		KELCH repeat	385..428	CDD:276965	12/42 (29%)
		KELCH repeat	432..475	CDD:276965	17/42 (40%)
		KELCH repeat	479..523	CDD:276965	15/45 (33%)
		KELCH repeat	526..571	CDD:276965	15/44 (34%)
		KELCH repeat	573..617	CDD:276965	11/43 (26%)
Klhl2	NP_001406494.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		6/22 (27%)
		BTB_POZ_KLHL2_Mayven	35..155	CDD:349647	45/139 (32%)
		PHA03098	56..573	CDD:222983	164/547 (30%)
		BACK_KLHL2_Mayven	153..282	CDD:350587	38/134 (28%)
		Kelch 1	308..353		13/51 (25%)
		KELCH repeat	343..386	CDD:276965	12/42 (29%)
		Kelch 2	354..400		14/45 (31%)
		KELCH repeat	390..434	CDD:276965	18/43 (42%)
		Kelch 3	402..447		18/44 (41%)
		Kelch 4	449..496		18/46 (39%)
		KELCH repeat	486..530	CDD:276965	14/43 (33%)
		Kelch 5	497..543		15/45 (33%)
		KELCH repeat	533..579	CDD:276965	13/51 (25%)
		Kelch 6	545..591		13/48 (27%)