Protein Alignment klhl10 and Klhl6

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: XP_063126397.1
• Gene: Klhl6 / 287974
• RGDID: 1307521
• Length: 647
• Species: Rattus norvegicus
• Alignment Length: 620
• Identity: 155/620 - (25%)
• Similarity: 270/620 - (43%)
• Gaps: 85/620 - (13%)

  Fly    70 NTLNELREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFR------------AQFTGFNAD----- 117
            |.|..|||:|.|.|..:.|....|:.||.::.:.|:|||            :..||.:.|
  Rat    58 NGLETLREENALTDVILCVDIQEFSCHRVVLAAASNYFRSASRALSSTYSVSSVTGHHRDQNLFM 122

  Fly   118 --TPGCVDGSDAKKNNNFIHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLVK 180
              ...|.|..:  |....|.|.||.:..|:.::.|.|..:..|::.||..:|..|:....:.||.
  Rat   123 NVAMFCNDLKE--KYEKRIIIKGVDAETMHTLLNYTYTSKALITKQNVQRVLEAANLFQFLQLVD 185

  Fly   181 KCKDYLGRILTPENCVSIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNIDILDMSAEDFYSIIS 245
            .|..:|...|.||||:.|:..|....|:.|..:.::|.::.|.:: ..:.:.|::..:..|.|:.
  Rat   186 ACASFLTEALNPENCIGILRLADTHSLDSLKTQVQSYIIQNFVQI-LNSEEFLELPVDTLYHILR 249

  Fly   246 DDELNTREEDHVWKLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYVLECEAAK 310
            .|:|...||..|::..:.|:......|...:..::..|||.|:.|..|:|.|:..|.:.:|....
  Rat   250 SDDLCVTEESQVFETVMSWVRHKQSERLCLLPCVLENVRLPLLDPWYFVEMVEADPLIRQCPEVF 314

  Fly   311 PLIVDTFKFMYDLDFLNPQADELTTPPLAMPRLPHEVIFAIGGWSGGTSKGCIETYDTRADRWVT 375
            ||:.:.  .||.|.. |....|.|.|  .|.....||...||        ||     |:.:|:|.
  Rat   315 PLLQEA--RMYHLSG-NEIISERTKP--RMHEFQSEVFMIIG--------GC-----TKDERFVA 361

  Fly   376 -INAEDPAG---------PRAYH------------GTAVLGFKIFSIGG----YDGVEYFNTCRV 414
             :...||..         |...|            ....|..:::..||    :|..:|.::.
  Rat   362 EVTCLDPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSI-- 424

  Fly   415 FDAVKKKWNEIAPMHCRRCYVSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQR 479
                 .||.:|..::..|....:..|.|.:|.|||:||..|:|.||.|:|..|.||...|:.:..
  Rat   425 -----NKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHV 484

  Fly   480 SDASACTLQERIYATGGF-NGQECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGG 543
            |..:|.:.::::|..||. ||:...|..:.|||.||.|.....|......::.|:|::.:||:||
  Rat   485 SSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWVLKSAMPVEAKCINAVSFQDHIYVVGG 549

  Fly   544 FNGTARLSTGERFDPDTQTWHFIREMNHSRSNFGLEIIDDMIFAIGGFNGVSTISHTE-CYVAET 607
                 .:.....:.|...:|..:.:::|.|::.|:...::.::..||.:..:.:..|. |:..|.
  Rat   550 -----AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNKLYITGGRDEKNEVIATVLCWDPEA 609

  Fly   608 DEWMEATDMNIVRSALSANNIAGLPNKRDYIHKER 642
               .:.|:..::...:|.:....:  ::.|.|..|
  Rat   610 ---QKLTEECVLPRGVSHHGSVTI--RKSYTHIRR 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	14/37 (38%)
		PHA03098	86..610	CDD:222983	142/570 (25%)
		KELCH repeat	385..428	CDD:276965	9/58 (16%)
		KELCH repeat	432..475	CDD:276965	18/42 (43%)
		KELCH repeat	479..523	CDD:276965	14/44 (32%)
		KELCH repeat	526..571	CDD:276965	8/44 (18%)
		KELCH repeat	573..617	CDD:276965	8/44 (18%)
Klhl6	XP_063126397.1	None