Protein Alignment klhl10 and KLHL3

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_059111.2
• Gene: KLHL3 / 26249
• HGNCID: 6354
• Length: 587
• Species: Homo sapiens
• Alignment Length: 616
• Identity: 195/616 - (31%)
• Similarity: 314/616 - (50%)
• Gaps: 48/616 - (7%)

  Fly    41 EDKTLGIGRKTIL-------NAHTKSLAPIVSDEALNTLNELREQNLLCDAQISVGEDV-FNVHR 97
            |.:::.:..:|::       |..|.::.|....:|...:||||.:.||||..| |.||| ...||
Human     2 EGESVKLSSQTLIQAGDDEKNQRTITVNPAHMGKAFKVMNELRSKQLLCDVMI-VAEDVEIEAHR 65

  Fly    98 AIMCSCSSYFRAQFTGFNADTPGCVDGSDAKKNNNFIHIPGVSSCIMNCVIQYAYLRQTNISESN 162
            .::.:||.||.|.|||..::       |.|||    |.|..|....::.:|.|.|..:..::|.|
Human    66 VVLAACSPYFCAMFTGDMSE-------SKAKK----IEIKDVDGQTLSKLIDYIYTAEIEVTEEN 119

  Fly   163 VHELLICADYVGMVGLVKKCKDYLGRILTPENCVSIMGFARFRFLEDLHLKARNYTLRYFTEVAY 227
            |..||..|..:.::.:.:.|.|:|...|.|.||:.|..||......||..:|..|..::|.||..
Human   120 VQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVML 184

  Fly   228 RNIDILDMSAEDFYSIISDDELNTREEDHVWKLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKC 292
            .. :.|.:|.:...|:||.|:|....|:.|::..:.||:...|:|..|:|.||..|||.|:....
Human   185 GE-EFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDY 248

  Fly   293 FMEEVKEHPYVLECEAAKPLIVDTFKF-MYDLD----FLNPQADELTTPPLAMPRLPHEVIFAIG 352
            .::.|:|...:......|..:::..|: :..||    ..||:....|  |:::|:    |:..:|
Human   249 LVQTVEEEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRT--PVSLPK----VMIVVG 307

  Fly   353 GWSGGTSKGCIETYDTRADRWVTINAEDPAGPRAYHGTAVLGFKIFSIGGYDGVEYFNTCRVFDA 417
            |.:....:. :|.||...|||..| ||.|: .|...|...:...::::||::|.....|..|:|.
Human   308 GQAPKAIRS-VECYDFEEDRWDQI-AELPS-RRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDG 369

  Fly   418 VKKKWNEIAPMHCRRCYVSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQRSDA 482
            ||.:|..||.|..||..:....||.::||:||:||...|.:||.|:.:||:|..:.|||.:||..
Human   370 VKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSV 434

  Fly   483 SACTLQERIYATGGFNG--QECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGGFN 545
            ....::.::||.||::|  ::||.:.|.|:|.||.|..:.:|:.||||........|||..||.:
Human   435 GVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHD 499

  Fly   546 GTARLSTGERFDPDTQTWHFIREMNHSRSNFGLEIIDDMIFAIGGFNGVSTISHTECYVAETDEW 610
            |.....:.|.:||.|.||..:.:||..|.|.|:..::.:::.:||.:|...::..|.|...||:|
Human   500 GPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKW 564

  Fly   611 -MEATDMNIVRSALSANNIAGLPNKRDYIHK 640
             :..|:|:..||      .||:.    .|||
Human   565 TLLPTNMSTGRS------YAGVA----VIHK 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	20/46 (43%)
		PHA03098	86..610	CDD:222983	171/531 (32%)
		KELCH repeat	385..428	CDD:276965	13/42 (31%)
		KELCH repeat	432..475	CDD:276965	16/42 (38%)
		KELCH repeat	479..523	CDD:276965	15/45 (33%)
		KELCH repeat	526..571	CDD:276965	16/44 (36%)
		KELCH repeat	573..617	CDD:276965	12/44 (27%)
KLHL3	NP_059111.2	BTB_POZ_KLHL3	29..149	CDD:349648	45/131 (34%)
		PHA03098	47..566	CDD:222983	176/540 (33%)
		BACK_KLHL3	147..276	CDD:350588	39/129 (30%)
		KELCH repeat	297..333	CDD:276965	12/41 (29%)
		Kelch 1	302..347		15/47 (32%)
		KELCH repeat	337..380	CDD:276965	13/42 (31%)
		Kelch 2	348..394		15/45 (33%)
		KELCH repeat	384..428	CDD:276965	17/43 (40%)
		Kelch 3	396..441		18/44 (41%)
		KELCH repeat	431..476	CDD:276965	15/44 (34%)
		Kelch 4	442..490		18/47 (38%)
		KELCH repeat	480..524	CDD:276965	15/43 (35%)
		Kelch 5	491..537		17/45 (38%)
		KELCH repeat	527..573	CDD:276965	13/45 (29%)
		Kelch 6	539..585		15/55 (27%)