Protein Alignment klhl10 and Klhl6

DIOPT Version :10

• Sequence 1: NP_001015100.2
• Gene: klhl10 / 3354863
• FlyBaseID: FBgn0040038
• Length: 767
• Species: Drosophila melanogaster
• Sequence 2: NP_001404141.1
• Gene: Klhl6 / 239743
• MGIID: 2686922
• Length: 647
• Species: Mus musculus
• Alignment Length: 620
• Identity: 155/620 - (25%)
• Similarity: 272/620 - (43%)
• Gaps: 85/620 - (13%)

  Fly    70 NTLNELREQNLLCDAQISVGEDVFNVHRAIMCSCSSYFRAQ------------FTGFNAD----- 117
            |.|..|||:|.|.|..:.|....|:.||.::.:.|:|||.|            .||.:.|
Mouse    58 NGLETLREENALTDVILCVDVQEFSCHRVVLAAASNYFRLQVRALSSTYSVSSVTGHHGDQNLSM 122

  Fly   118 --TPGCVDGSDAKKNNNFIHIPGVSSCIMNCVIQYAYLRQTNISESNVHELLICADYVGMVGLVK 180
              ...|.|..:  |....|.|.||.:..|:.::.|.|..:..|::.||..:|..|:....:.||.
Mouse   123 HVAMFCNDLKE--KYEKRIIIKGVDAETMHTLLVYTYTSKALITKQNVQRVLEAANLFQFLQLVD 185

  Fly   181 KCKDYLGRILTPENCVSIMGFARFRFLEDLHLKARNYTLRYFTEVAYRNIDILDMSAEDFYSIIS 245
            .|..:|...|.||||:.|:..|....|:.|.::.::|.::.|.:: ..:.:.|::..:..|.|:.
Mouse   186 ACASFLTEALNPENCIGILRLADTHSLDSLKMQVQSYIIQNFVQI-LNSEEFLELPVDTLYHILR 249

  Fly   246 DDELNTREEDHVWKLCVKWIDRNPESRKRHVAHLMTGVRLGLMTPKCFMEEVKEHPYVLECEAAK 310
            .|:|...||..|::..:.|:......|...:..::..|||.|:.|..|:|.|:..|.:.:|....
Mouse   250 SDDLCVTEEAQVFETVMSWVRHKQSERLCLLPCVLENVRLPLLDPWYFVEMVEADPLIRQCPEVF 314

  Fly   311 PLIVDTFKFMYDLDFLNPQADELTTPPLAMPRLPHEVIFAIGGWSGGTSKGCIETYDTRADRWVT 375
            ||:.:.  .||.|.. |....|.|.|  .|.....||...||        ||     |:.:|:|.
Mouse   315 PLLQEA--RMYHLSG-NEIISERTKP--RMHEFQSEVFMIIG--------GC-----TKDERFVA 361

  Fly   376 -INAEDPAG---------PRAYH------------GTAVLGFKIFSIGG----YDGVEYFNTCRV 414
             :...||..         |...|            ....|..:::..||    :|..:|.::.
Mouse   362 EVTCLDPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSI-- 424

  Fly   415 FDAVKKKWNEIAPMHCRRCYVSVTELNGMIYAIGGYDGHNRLNTVERYNPRTNQWSVIPPMNMQR 479
                 .||.:|..::..|....:..|.|.:|.:||:||..|:|.||.|:|..|.||...|:::..
Mouse   425 -----NKWIQIEYLNIGRWRHKMVVLGGKVYVLGGFDGLQRINNVETYDPFHNCWSEAAPLHVHV 484

  Fly   480 SDASACTLQERIYATGGF-NGQECLDSAEYYDPVTNVWTRIPNMNHRRSGVSCVAFRNQLYVIGG 543
            |..:|.:.::::|..||. ||:...|..:.|||.||.|.....|......::.|:|::.:||:||
Mouse   485 SSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWVLKSAMPVEAKCINAVSFQDHIYVVGG 549

  Fly   544 FNGTARLSTGERFDPDTQTWHFIREMNHSRSNFGLEIIDDMIFAIGGFNGVSTISHTE-CYVAET 607
                 .:.....:.|...:|..:.:::|.|::.|:...::.::..||.:..:.:..|. |:..|.
Mouse   550 -----AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNKLYITGGRDEKNEVIATVLCWDPEA 609

  Fly   608 DEWMEATDMNIVRSALSANNIAGLPNKRDYIHKER 642
               .:.|:..::...:|.:....:  ::.|.|..|
Mouse   610 ---QKLTEECVLPRGVSHHGSVTI--RKSYTHIRR 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klhl10	NP_001015100.2	BTB_POZ	62..>108	CDD:453885	14/37 (38%)
		PHA03098	86..610	CDD:222983	142/570 (25%)
		KELCH repeat	385..428	CDD:276965	9/58 (16%)
		KELCH repeat	432..475	CDD:276965	17/42 (40%)
		KELCH repeat	479..523	CDD:276965	14/44 (32%)
		KELCH repeat	526..571	CDD:276965	8/44 (18%)
		KELCH repeat	573..617	CDD:276965	8/44 (18%)
Klhl6	NP_001404141.1	BTB_POZ	46..202	CDD:453885	44/145 (30%)
		PHA03098	84..591	CDD:222983	135/539 (25%)
		BACK	195..302	CDD:475122	28/107 (26%)
		KELCH repeat	396..433	CDD:276965	8/43 (19%)
		KELCH repeat	437..481	CDD:276965	18/43 (42%)
		KELCH repeat	484..530	CDD:276965	15/45 (33%)
		KELCH repeat	532..572	CDD:276965	8/44 (18%)
		KELCH repeat	574..619	CDD:276965	8/47 (17%)
		Kelch_1	574..611	CDD:396078	7/39 (18%)